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PreprintCC BYChemRxiv

Direct synthesis of high aspect ratio chiral gold nanofibers

  • Mathias R. S. Nielsen1,2
  • Stephany Beyerstedt1,2,3
  • Rebekka Klemmt4,2
  • Espen D. Bøjesen1,2
  • Marcos López Hernández1,2,5
  • Jan Skov Pedersen1,2,5
  • Miguel Alexandre Ramos-Docampo1,2
5 affiliations
  1. 1Interdisciplinary Nanoscience Center (iNANO
  2. 2Aarhus University
  3. 3University of Chinese Academy of Sciences
  4. 4Center for Sustainable Energy Materials, Department of Chemistry
  5. 5Department of Chemistry
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Abstract

Chirality, a fundamental characteristic of nature, plays a decisive role in molecular recognition, catalysis, and cellular organization. Translating this asymmetry into synthetic systems has the potential to unlock new functionalities at the interface of nanoscience and biology. Here, we report the first synthesis of high aspect ratio chiral gold nanofibers, a class of one-dimensional chiral plasmonic materials, fabricated via a seedless, soft-templated, ligandassisted growth method. Using D- and L-cysteine as chiral inducers, we direct the anisotropic reduction of gold ions to produce left- and right-handed nanofibers with tunable surface topologies. The resulting chiral gold nanofibers exhibit pronounced, mirror-symmetric circular dichroism signals and characteristic plasmonic resonances, confirming their intrinsic structural chirality. 4D scanning transmission electron microscopy analysis demonstrates that the atoms arrange in a chiral fashion, governing the final chirality of the gold nanofibers. Beyond their optical properties, these gold nanofibers provide topographical cues that promote directed neuron cell alignment when integrated into paper-based chips, offering a simple platform to model neuronal organization. Altogether, this effort establishes a scalable route to chiral gold architectures and demonstrates their capacity to couple plasmonic chirality with biological function, opening a new pathway for nanomaterials-based neuroregeneration.

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Cite

BibTeXRIS
BibTeX
@misc{nielsen2026direct,
  title = {{Direct synthesis of high aspect ratio chiral gold nanofibers}},
  author = {Mathias R. S. Nielsen and Stephany Beyerstedt and Rebekka Klemmt and Espen D. Bøjesen and Marcos López Hernández and Jan Skov Pedersen and Miguel Alexandre Ramos-Docampo},
  howpublished = {ChemRxiv},
  year = {2026},
  month = aug,
  doi = {10.26434/chemrxiv.15008070/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008070/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Direct synthesis of high aspect ratio chiral gold nanofibers
AU  - Mathias R. S. Nielsen
AU  - Stephany Beyerstedt
AU  - Rebekka Klemmt
AU  - Espen D. Bøjesen
AU  - Marcos López Hernández
AU  - Jan Skov Pedersen
AU  - Miguel Alexandre Ramos-Docampo
PY  - 2026
DA  - 2026/08/31
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15008070/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008070/v1
AB  - Chirality, a fundamental characteristic of nature, plays a decisive role in molecular recognition, catalysis, and cellular organization. Translating this asymmetry into synthetic systems has the potential to unlock new functionalities at the interface of nanoscience and biology. Here, we report the first synthesis of high aspect ratio chiral gold nanofibers, a class of one-dimensional chiral plasmonic materials, fabricated via a seedless, soft-templated, ligandassisted growth method. Using D- and L-cysteine as chiral inducers, we direct the anisotropic reduction of gold ions to produce left- and right-handed nanofibers with tunable surface topologies. The resulting chiral gold nanofibers exhibit pronounced, mirror-symmetric circular dichroism signals and characteristic plasmonic resonances, confirming their intrinsic structural chirality. 4D scanning transmission electron microscopy analysis demonstrates that the atoms arrange in a chiral fashion, governing the final chirality of the gold nanofibers. Beyond their optical properties, these gold nanofibers provide topographical cues that promote directed neuron cell alignment when integrated into paper-based chips, offering a simple platform to model neuronal organization. Altogether, this effort establishes a scalable route to chiral gold architectures and demonstrates their capacity to couple plasmonic chirality with biological function, opening a new pathway for nanomaterials-based neuroregeneration.
ER  -