A cross-species atlas platform for comparative neuroscience in teleost fish
8 affiliations
- 1Visual and Data-Centric Computing, Zuse Institute Berlin, Takustraße 7, Berlin, Germany
- 2Research group behavioral neuroscience, Leibniz-Institut für Neurobiologie (LIN), Brenneckestraße 6, Magdeburg, Germany
- 3Centre for Organismal Studies (COS) Heidelberg, Heidelberg University, Im Neuenheimer Feld 230, Heidelberg, Germany
- 4Developmental Biology Unit, European Molecular Biology Laboratory (EMBL) Heidelberg, Meyerhofstraße 1, Heidelberg, Germany
- 5Department of Molecular and Cellular Biology, Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts USA
- 6Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France
- 7Department of Stem Cell and Regenerative Biology, Faculty of Arts and Sciences, Harvard University, Cambridge, Massachusetts USA
- 8Laboratoire MeLiS, Université Claude Bernard Lyon 1 - CNRS UMR5284 - Inserm U1314, Institut NeuroMyoGène, Faculté de Médecine et de Pharmacie, 8 Avenue Rockefeller, Lyon, France
Abstract
Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structures between two teleost larvae, medaka (Oryzias latipes) and zebrafish (Danio rerio). Crucially, the platform seamlessly integrates user-generated image volumes, facilitating quantitative comparisons of anatomical, transcriptional, and functional data across species and laboratories. Utilising these integrated tools, we identified regional anatomical differences and differentially expressed genes between the species. We further demonstrated functionally distinct telencephalic regions in both species that exhibit divergent responses to social stimuli, suggesting an evolutionary divergence in social processing mechanisms. This web-based, interactive atlas platform promotes data exchange and knowledge sharing within the teleost community. Its scalable design permits effortless multi-group contributions, enabling expansion into a continuously growing, globally accessible database.
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BibTeX
@article{vohra2026crossspecies,
title = {{A cross-species atlas platform for comparative neuroscience in teleost fish}},
author = {Sumit Kumar Vohra and Tinatini Tavhelidse-Suck and Simon Knoblich and Ali Seleit and Jonathan Boulanger-Weill and Sydney Chambule and Ariel Aspiras and Cristina Santoriello and Owen Randlett and Joachim Wittbrodt and Jeff W. Lichtman and Mark Fishman and Hans-Christian Hege and Daniel Baum and Florian Engert and Yasuko Isoe},
journal = {Nature Communications},
year = {2026},
month = sep,
doi = {10.1038/s41467-026-77879-1},
url = {https://doi.org/10.1038/s41467-026-77879-1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - A cross-species atlas platform for comparative neuroscience in teleost fish
AU - Sumit Kumar Vohra
AU - Tinatini Tavhelidse-Suck
AU - Simon Knoblich
AU - Ali Seleit
AU - Jonathan Boulanger-Weill
AU - Sydney Chambule
AU - Ariel Aspiras
AU - Cristina Santoriello
AU - Owen Randlett
AU - Joachim Wittbrodt
AU - Jeff W. Lichtman
AU - Mark Fishman
AU - Hans-Christian Hege
AU - Daniel Baum
AU - Florian Engert
AU - Yasuko Isoe
PY - 2026
DA - 2026/09/25
JO - Nature Communications
DO - 10.1038/s41467-026-77879-1
UR - https://doi.org/10.1038/s41467-026-77879-1
AB - Uncovering general principles connecting neural circuits to behaviour requires comparative brain analyses across species. To advance these efforts, we developed a standardised workflow and a unified brain atlas platform for the quantitative comparison of neural structures between two teleost larvae, medaka (Oryzias latipes) and zebrafish (Danio rerio). Crucially, the platform seamlessly integrates user-generated image volumes, facilitating quantitative comparisons of anatomical, transcriptional, and functional data across species and laboratories. Utilising these integrated tools, we identified regional anatomical differences and differentially expressed genes between the species. We further demonstrated functionally distinct telencephalic regions in both species that exhibit divergent responses to social stimuli, suggesting an evolutionary divergence in social processing mechanisms. This web-based, interactive atlas platform promotes data exchange and knowledge sharing within the teleost community. Its scalable design permits effortless multi-group contributions, enabling expansion into a continuously growing, globally accessible database.
SN - 2041-1723
ER -