Sexual function, psychological distress, and health-related quality of life in HPV-positive women with and without LEEP: a cross-sectional comparative study
- 1Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye
Abstract
Objective To compare sexual function, psychological distress, and health-related quality of life (HRQoL) between HPV-positive women with and without prior loop electrosurgical excision procedure (LEEP).Methods In this cross-sectional study, 226 HPV-positive women (LEEP, n = 112; no LEEP, n = 114) attending a tertiary clinic in Mersin, Türkiye, between January and June 2026 completed the FSFI (primary outcome), HADS, and SF-36. Analyzes used Mann–Whitney U and χ2 tests and multivariable regression, with Holm correction within prespecified families.Results FSFI scores were lower in the LEEP group (median 14.6 vs 22.3; median difference −3.3, 95% CI −6.4 to −1.0; rank-biserial r = −0.23). The difference persisted after adjustment (−4.0, 95% CI −6.8 to −1.2) and among sexually active women. Desire, arousal, lubrication, and satisfaction were lower after Holm correction. Anxiety, depression, and SF-36 domains showed no significant differences. Most LEEP participants had CIN2–3, unlike controls. Time since LEEP was unrelated to outcomes.Conclusion Prior LEEP was associated with modestly lower sexual function, without significant differences in psychological distress or HRQoL. Differences in lesion grade and absence of pretreatment assessments preclude attributing this association to LEEP itself. Sexual-health assessment may be useful during follow-up.
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BibTeX
@article{yuksek2026sexual,
title = {{Sexual function, psychological distress, and health-related quality of life in HPV-positive women with and without LEEP: a cross-sectional comparative study}},
author = {Şahin Yüksek and Hasan Turan and Numan Bilgiç and Mürşide Çevikoğlu Kıllı and Osman Doğan and Mehmet Sait Bakır},
journal = {Journal of Psychosomatic Obstetrics and Gynecology},
year = {2026},
month = oct,
doi = {10.1080/0167482x.2026.2753611},
url = {https://doi.org/10.1080/0167482x.2026.2753611},
note = {CC BY},
}
RIS
TY - JOUR
TI - Sexual function, psychological distress, and health-related quality of life in HPV-positive women with and without LEEP: a cross-sectional comparative study
AU - Şahin Yüksek
AU - Hasan Turan
AU - Numan Bilgiç
AU - Mürşide Çevikoğlu Kıllı
AU - Osman Doğan
AU - Mehmet Sait Bakır
PY - 2026
DA - 2026/10/30
JO - Journal of Psychosomatic Obstetrics and Gynecology
DO - 10.1080/0167482x.2026.2753611
UR - https://doi.org/10.1080/0167482x.2026.2753611
AB - Objective To compare sexual function, psychological distress, and health-related quality of life (HRQoL) between HPV-positive women with and without prior loop electrosurgical excision procedure (LEEP).Methods In this cross-sectional study, 226 HPV-positive women (LEEP, n = 112; no LEEP, n = 114) attending a tertiary clinic in Mersin, Türkiye, between January and June 2026 completed the FSFI (primary outcome), HADS, and SF-36. Analyzes used Mann–Whitney U and χ2 tests and multivariable regression, with Holm correction within prespecified families.Results FSFI scores were lower in the LEEP group (median 14.6 vs 22.3; median difference −3.3, 95% CI −6.4 to −1.0; rank-biserial r = −0.23). The difference persisted after adjustment (−4.0, 95% CI −6.8 to −1.2) and among sexually active women. Desire, arousal, lubrication, and satisfaction were lower after Holm correction. Anxiety, depression, and SF-36 domains showed no significant differences. Most LEEP participants had CIN2–3, unlike controls. Time since LEEP was unrelated to outcomes.Conclusion Prior LEEP was associated with modestly lower sexual function, without significant differences in psychological distress or HRQoL. Differences in lesion grade and absence of pretreatment assessments preclude attributing this association to LEEP itself. Sexual-health assessment may be useful during follow-up.
SN - 1743-8942
SN - 0167-482X
ER -