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Peer-reviewedCC BY 4.0Frontiers in Oncology

A solitary brain metastasis from gastroesophageal junction adenocarcinoma 13 years after curative multimodality treatment: a case report and review of the literature

  • Sara Di Lorenzo1,2
  • Pasqualina Giordano3
  • Giuseppe Catapano4
  • Francesca Maria Giugliano5
  • Piera Federico3
  • Federico Frio4
  • Antonio D’Antonio6
  • Bruno Daniele3
  • Angelica Petrillo3
6 affiliations
  1. 1Medical Oncology, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”
  2. 2Medical Oncology Unit, “Cav. R. Apicella” Hospital
  3. 3Medical Oncology Unit, Ospedale del Mare
  4. 4Neurosurgery Unit, Ospedale del Mare
  5. 5Radiation Oncology Unit, Ospedale del Mare
  6. 6Pathology Unit, Ospedale del Mare
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Abstract

Brain metastases in gastroesophageal adenocarcinoma are uncommon and can cause substantial neurological morbidity. Here, we report the case of a 58-year-old patient who developed a solitary brain metastasis thirteen years after curative-intent multimodality treatment for a Siewert type II gastroesophageal junction adenocarcinoma (GEJA). The intracranial lesion was initially radiologically suspected to be a primary brain tumour, while systemic restaging showed no extracranial disease. Histopathology, immunohistochemistry, clinical history, and methylome profiling supported metastatic recurrence from the prior GEJA. This case is noteworthy for the exceptionally long disease-free interval, the brain-only presentation after routine oncological surveillance had ended, and the diagnostic importance of tissue confirmation and integrated pathological assessment when a new intracranial lesion appears many years after curative treatment. This case supports maintaining late metastatic recurrence in the differential diagnosis of symptomatic brain lesions without implying a role for routine neuroimaging in asymptomatic long-term survivors.

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Cite

BibTeXRIS
BibTeX
@article{lorenzo2026solitary,
  title = {{A solitary brain metastasis from gastroesophageal junction adenocarcinoma 13 years after curative multimodality treatment: a case report and review of the literature}},
  author = {Sara Di Lorenzo and Pasqualina Giordano and Giuseppe Catapano and Francesca Maria Giugliano and Piera Federico and Federico Frio and Antonio D’Antonio and Bruno Daniele and Angelica Petrillo},
  journal = {Frontiers in Oncology},
  year = {2026},
  month = oct,
  doi = {10.3389/fonc.2026.1892637},
  url = {https://www.frontiersin.org/articles/10.3389/fonc.2026.1892637/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A solitary brain metastasis from gastroesophageal junction adenocarcinoma 13 years after curative multimodality treatment: a case report and review of the literature
AU  - Sara Di Lorenzo
AU  - Pasqualina Giordano
AU  - Giuseppe Catapano
AU  - Francesca Maria Giugliano
AU  - Piera Federico
AU  - Federico Frio
AU  - Antonio D’Antonio
AU  - Bruno Daniele
AU  - Angelica Petrillo
PY  - 2026
DA  - 2026/10/16
JO  - Frontiers in Oncology
DO  - 10.3389/fonc.2026.1892637
UR  - https://www.frontiersin.org/articles/10.3389/fonc.2026.1892637/full
AB  - Brain metastases in gastroesophageal adenocarcinoma are uncommon and can cause substantial neurological morbidity. Here, we report the case of a 58-year-old patient who developed a solitary brain metastasis thirteen years after curative-intent multimodality treatment for a Siewert type II gastroesophageal junction adenocarcinoma (GEJA). The intracranial lesion was initially radiologically suspected to be a primary brain tumour, while systemic restaging showed no extracranial disease. Histopathology, immunohistochemistry, clinical history, and methylome profiling supported metastatic recurrence from the prior GEJA. This case is noteworthy for the exceptionally long disease-free interval, the brain-only presentation after routine oncological surveillance had ended, and the diagnostic importance of tissue confirmation and integrated pathological assessment when a new intracranial lesion appears many years after curative treatment. This case supports maintaining late metastatic recurrence in the differential diagnosis of symptomatic brain lesions without implying a role for routine neuroimaging in asymptomatic long-term survivors.
SN  - 2234-943X
ER  -