Glucocorticoid Therapy and Miglitol Ameliorate Reactive Hypoglycemia Secondary to Late Dumping Syndrome

Abstract

We report a case in which low-dose prednisolone (LD-PSL) and an absorbable α-glucosidase inhibitor (miglitol) effectively treated reactive hypoglycemia caused by late dumping syndrome. A 73-year-old man underwent gastric tube reconstruction after an esophagectomy for esophageal cancer. Frequent diet management and a non-absorbable α-glucosidase inhibitor (voglibose) were prescribed to treat the reactive hypoglycemia caused by late dumping syndrome; however, hypoglycemia persisted. Changing the treatment to LD-PSL and miglitol ameliorated the reactive hypoglycemia and led to a resolution of hypoglycemic symptoms. Treatment with LD-PSL and miglitol is an effective treatment option for late dumping syndrome which does not respond to either guideline-based dietary modifications or voglibose treatment.

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BibTeX RIS

BibTeX

@article{saito2026glucocorticoid,
  title = {{Glucocorticoid Therapy and Miglitol Ameliorate Reactive Hypoglycemia Secondary to Late Dumping Syndrome}},
  author = {Manabu Saito and Hiroshi Uchino and Arisa Yoshida and Genki Sato and Takahisa Hirose},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6534-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6534-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Glucocorticoid Therapy and Miglitol Ameliorate Reactive Hypoglycemia Secondary to Late Dumping Syndrome
AU  - Manabu Saito
AU  - Hiroshi Uchino
AU  - Arisa Yoshida
AU  - Genki Sato
AU  - Takahisa Hirose
PY  - 2026
DA  - 2026/10/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6534-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/19/65_6534-25/_article
AB  - We report a case in which low-dose prednisolone (LD-PSL) and an absorbable α-glucosidase inhibitor (miglitol) effectively treated reactive hypoglycemia caused by late dumping syndrome. A 73-year-old man underwent gastric tube reconstruction after an esophagectomy for esophageal cancer. Frequent diet management and a non-absorbable α-glucosidase inhibitor (voglibose) were prescribed to treat the reactive hypoglycemia caused by late dumping syndrome; however, hypoglycemia persisted. Changing the treatment to LD-PSL and miglitol ameliorated the reactive hypoglycemia and led to a resolution of hypoglycemic symptoms. Treatment with LD-PSL and miglitol is an effective treatment option for late dumping syndrome which does not respond to either guideline-based dietary modifications or voglibose treatment.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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