Scalp EEG and Intrinsic Optical Signal Imaging for Noninvasive Detection of Spreading Depolarizations in the Rat Cortex
Abstract
Spreading depolarization (SD) is a slowly propagating wave of massive neuronal and glial depolarization in the cerebral cortex that occurs in various brain diseases. However, noninvasive SD detection remains challenging. Here, we used scalp EEG and intrinsic optical signal (IOS) recordings in rats of both sexes to assess the feasibility of noninvasively detecting high-potassium-induced SDs in the cortex. Scalp EEG failed to detect DC-shifts but revealed a characteristic SD-related depression of AC-EEG activity, while concurrent infrared IOS recordings captured reliable SD-associated signals. Although the magnitudes of AC-EEG depression and IOS signals during scalp recordings were several times smaller than those recorded epidurally, both techniques enabled high-fidelity SD detection. These findings demonstrate that noninvasive monitoring of scalp EEG and infrared IOS imaging reliably detects SDs in the rat cerebral cortex.
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BibTeX
@article{mingazov2026scalp,
title = {{Scalp EEG and Intrinsic Optical Signal Imaging for Noninvasive Detection of Spreading Depolarizations in the Rat Cortex}},
author = {Bulat Mingazov and Karina Tukhvatullina and Roustem Khazipov and Azat Nasretdinov},
journal = {eneuro},
year = {2026},
month = oct,
doi = {10.1523/eneuro.0130-26.2026},
url = {https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0130-26.2026},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - JOUR
TI - Scalp EEG and Intrinsic Optical Signal Imaging for Noninvasive Detection of Spreading Depolarizations in the Rat Cortex
AU - Bulat Mingazov
AU - Karina Tukhvatullina
AU - Roustem Khazipov
AU - Azat Nasretdinov
PY - 2026
DA - 2026/10/15
JO - eneuro
DO - 10.1523/eneuro.0130-26.2026
UR - https://www.eneuro.org/lookup/doi/10.1523/ENEURO.0130-26.2026
AB - Spreading depolarization (SD) is a slowly propagating wave of massive neuronal and glial depolarization in the cerebral cortex that occurs in various brain diseases. However, noninvasive SD detection remains challenging. Here, we used scalp EEG and intrinsic optical signal (IOS) recordings in rats of both sexes to assess the feasibility of noninvasively detecting high-potassium-induced SDs in the cortex. Scalp EEG failed to detect DC-shifts but revealed a characteristic SD-related depression of AC-EEG activity, while concurrent infrared IOS recordings captured reliable SD-associated signals. Although the magnitudes of AC-EEG depression and IOS signals during scalp recordings were several times smaller than those recorded epidurally, both techniques enabled high-fidelity SD detection. These findings demonstrate that noninvasive monitoring of scalp EEG and infrared IOS imaging reliably detects SDs in the rat cerebral cortex.
SN - 2373-2822
ER -