Synergistic effect of a naturally derived Lactobacillus gasseri and Rumex hanus by. extract on alleviating hyperuricemia in mice via uricolysis, gut microbiota modulation, and anti-inflammation
Abstract
Hyperuricemia (HUA) is widespread, and since conventional long-term treatments can be toxic, safer multi-target alternatives are required. Here, we tested a naturally derived synbiotic pairing of the uricolytic probiotic Lactobacillus gasseri SYP-B4432 with a polyphenol-rich Rumex hanus by. extract in a mouse model of hyperuricemia. In just five weeks of daily treatment, the combination reduced serum uric acid by 57.86%, suppressed serum xanthine oxidase activity by 14.31%, and restored the Bacteroidetes/Firmicutes ratio while lowering pro-inflammatory cytokines and attenuating renal histopathology. Importantly, no hepatic/renal impairment or body weight abnormalities were detected, confirming the safety of this intervention. Collectively, the probiotic–herbal duo alleviates HUA through the synergy of three modes of action: curtailing uric acid synthesis (via XOD inhibition), reshaping gut microbiota (to enhance UA excretion), and resolving renal inflammation (via cytokine modulation). This natural, safe, and multi-target synbiotic provides a clinically translatable strategy that may address the side effect limitations of conventional hyperuricemia drugs.
Related
- Physiological Responses and Transcriptomic Characteristics of Exogenous Trehalose Alleviating Cadmium Toxicity in Maize Seedlings
- The Urogenital Lactobacillus Axis Across Menopause: Connections Between the Vagina, Bladder, and Urinary Metabolome
- Longitudinal strain-level metagenomics reveals reciprocal Lactobacillus dynamics and outcome-associated protein variants during IVF treatment
- Chickpea flour (Cicer arietinum L) improves viability of potentially probiotics Lactobacillus plantarum S180.7 and Lactobacillus plantarum SBR64.7 in milk-based formulations
- Evodiamine attenuates hyperuricemia-associated gouty arthritis and renal injury through urate-inflammatory axis modulation
BibTeX
@article{sheng2026synergistic,
title = {{Synergistic effect of a naturally derived Lactobacillus gasseri and Rumex hanus by. extract on alleviating hyperuricemia in mice via uricolysis, gut microbiota modulation, and anti-inflammation}},
author = {Ying-Ying SHENG and Jia-Hui LV and Liang-Liang ZHU and Meng-Yue ZHANG and Ye LI and Shi-Qiao XU and Da-Wei YANG and Ze-Xu YU and Yi-Xuan ZHANG},
journal = {Bioscience of Microbiota, Food and Health},
year = {2026},
month = oct,
doi = {10.12938/bmfh.2026-029},
url = {https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-029/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Synergistic effect of a naturally derived Lactobacillus gasseri and Rumex hanus by. extract on alleviating hyperuricemia in mice via uricolysis, gut microbiota modulation, and anti-inflammation
AU - Ying-Ying SHENG
AU - Jia-Hui LV
AU - Liang-Liang ZHU
AU - Meng-Yue ZHANG
AU - Ye LI
AU - Shi-Qiao XU
AU - Da-Wei YANG
AU - Ze-Xu YU
AU - Yi-Xuan ZHANG
PY - 2026
DA - 2026/10/08
JO - Bioscience of Microbiota, Food and Health
DO - 10.12938/bmfh.2026-029
UR - https://www.jstage.jst.go.jp/article/bmfh/45/4/45_2026-029/_article
AB - Hyperuricemia (HUA) is widespread, and since conventional long-term treatments can be toxic, safer multi-target alternatives are required. Here, we tested a naturally derived synbiotic pairing of the uricolytic probiotic Lactobacillus gasseri SYP-B4432 with a polyphenol-rich Rumex hanus by. extract in a mouse model of hyperuricemia. In just five weeks of daily treatment, the combination reduced serum uric acid by 57.86%, suppressed serum xanthine oxidase activity by 14.31%, and restored the Bacteroidetes/Firmicutes ratio while lowering pro-inflammatory cytokines and attenuating renal histopathology. Importantly, no hepatic/renal impairment or body weight abnormalities were detected, confirming the safety of this intervention. Collectively, the probiotic–herbal duo alleviates HUA through the synergy of three modes of action: curtailing uric acid synthesis (via XOD inhibition), reshaping gut microbiota (to enhance UA excretion), and resolving renal inflammation (via cytokine modulation). This natural, safe, and multi-target synbiotic provides a clinically translatable strategy that may address the side effect limitations of conventional hyperuricemia drugs.
SN - 2186-3342
ER -