PSMD12 is a novel potential biomarker for lung adenocarcinoma and associated with prognosis in lung adenocarcinoma patients.
- 1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
- 2Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China. [email protected].
- 3Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China. [email protected].
Abstract
Background
This study aims to comprehensively evaluate the expression pattern of PSMD12 in lung adenocarcinoma (LUAD) and its impact on prognosis, and to explore its potential application value in the diagnosis and treatment of LUAD.Methods
This study employed bioinformatics analysis and molecular biology experiments to comprehensively investigate the expression pattern of the PSMD12 gene in LUAD and its association with LUAD patients' clinical features. First, we evaluated the differential expression of PSMD12 in 44 different tumor types and its relationship with the prognosis of LUAD patients. GO, KEGG, and GSEA were used to analyze the function of PSMD12. Secondly, TIMER was applied to evaluated the relationship between PSMD12 gene expression and immune infiltration characteristics in LUAD patients. Finally, RT-qPCR, CCK-8, clone formation assay, wound healing assay, and Transwell assay were used to verify the effects of knockdown PSMD12 expression on the proliferation, migration, and invasion abilities of LUAD cells.Results
Survival analysis results showed that high PSMD12 gene expression levels were significantly correlated with the poor prognosis of LUAD patients. The importance of PSMD12 in key metabolic pathways and disease processes such as neuroactive ligand-receptor interaction, taste and olfactory transduction, and steroid hormone biosynthesis was revealed. Immune infiltration analysis results showed that PSMD12 expression was negatively correlated with M2 macrophages, revealing the potential role of PSMD12 in regulating the immune microenvironment of LUAD. In vitro experiments verified the functional role of the PSMD12 in LUAD cells, indicating that knockdown of PSMD12 weakened the proliferation, migration, and invasion abilities of LUAD A549 and H1299 cells.Conclusions
High expression of PSMD12 may be closely related to poor prognosis in LUAD patients and promotes the malignant progression of LUAD by enhancing the proliferation, migration, and invasion of LUAD cells.
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BibTeX
@article{lu2026psmd12,
title = {{PSMD12 is a novel potential biomarker for lung adenocarcinoma and associated with prognosis in lung adenocarcinoma patients.}},
author = {Shuyu Lu and Yue Li and Huajian Peng and Xiang Gao and Zhanyu Xu and Huafu Zhou and Jianji Guo and Nuo Yang},
journal = {Journal of cardiothoracic surgery},
year = {2026},
month = aug,
doi = {10.1186/s13019-026-04601-z},
url = {https://europepmc.org/article/MED/42958575},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - PSMD12 is a novel potential biomarker for lung adenocarcinoma and associated with prognosis in lung adenocarcinoma patients.
AU - Shuyu Lu
AU - Yue Li
AU - Huajian Peng
AU - Xiang Gao
AU - Zhanyu Xu
AU - Huafu Zhou
AU - Jianji Guo
AU - Nuo Yang
PY - 2026
DA - 2026/08/03
JO - Journal of cardiothoracic surgery
DO - 10.1186/s13019-026-04601-z
UR - https://europepmc.org/article/MED/42958575
AB - Background This study aims to comprehensively evaluate the expression pattern of PSMD12 in lung adenocarcinoma (LUAD) and its impact on prognosis, and to explore its potential application value in the diagnosis and treatment of LUAD.Methods This study employed bioinformatics analysis and molecular biology experiments to comprehensively investigate the expression pattern of the PSMD12 gene in LUAD and its association with LUAD patients' clinical features. First, we evaluated the differential expression of PSMD12 in 44 different tumor types and its relationship with the prognosis of LUAD patients. GO, KEGG, and GSEA were used to analyze the function of PSMD12. Secondly, TIMER was applied to evaluated the relationship between PSMD12 gene expression and immune infiltration characteristics in LUAD patients. Finally, RT-qPCR, CCK-8, clone formation assay, wound healing assay, and Transwell assay were used to verify the effects of knockdown PSMD12 expression on the proliferation, migration, and invasion abilities of LUAD cells.Results Survival analysis results showed that high PSMD12 gene expression levels were significantly correlated with the poor prognosis of LUAD patients. The importance of PSMD12 in key metabolic pathways and disease processes such as neuroactive ligand-receptor interaction, taste and olfactory transduction, and steroid hormone biosynthesis was revealed. Immune infiltration analysis results showed that PSMD12 expression was negatively correlated with M2 macrophages, revealing the potential role of PSMD12 in regulating the immune microenvironment of LUAD. In vitro experiments verified the functional role of the PSMD12 in LUAD cells, indicating that knockdown of PSMD12 weakened the proliferation, migration, and invasion abilities of LUAD A549 and H1299 cells.Conclusions High expression of PSMD12 may be closely related to poor prognosis in LUAD patients and promotes the malignant progression of LUAD by enhancing the proliferation, migration, and invasion of LUAD cells.
SN - 1749-8090
ER -