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Peer-reviewedCC BY-NC-NDBMC neurology

Association between body weight reduction and electrodiagnostic findings in peroneal neuropathy at the fibular head.

  • Metin Balduz1
  • U Cigdem Alaydin2
  • Halit Fidancı3
  • Mehmet Yıldız2
  • Şencan Buturak2
  • Zülfikar Arlıer2
  1. 1Department of Neurology, University of Health Sciences Adana City Training and Research Hospital, Adana, Türkiye. [email protected].
  2. 2Department of Neurology, University of Health Sciences Adana City Training and Research Hospital, Adana, Türkiye.
  3. 3Department of Neurology, Division of Clinical Neurophysiology, University of Health Sciences Adana City Training and Research Hospital, Adana, Türkiye.
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Abstract

Background

Peroneal neuropathy at the fibular head (PNFH) is often associated with recent weight loss (WL); however, it remains unclear how weight-loss characteristics are related to nerve involvement. This study aimed to investigate the relationship between WL characteristics and clinical and electrodiagnostic findings in patients with PNFH.Methods

Thirty-seven adults diagnosed with PNFH between October 2018 and June 2022 were retrospectively analyzed. Patients were divided into WL (n = 22) and non-WL (n = 15) groups. WL was defined as a ≥ 5% reduction in baseline body weight within one to six months. WL parameters included absolute WL, WL percentage (WLP%), WL per month (WLPM), and BMI reduction (BMI-R). Clinical and electrophysiological findings were compared between groups.Results

The mean WL was 21.5 ± 13.2 kg over a median of 3.5 months. Overall electrophysiological findings were similar between groups, except for a higher prevalence of abnormal superficial peroneal nerve conduction studies in the WL group (10/22 vs. 2/15, p = 0.043). Sensory nerve conduction velocity showed significant negative correlations with admission weight (p = 0.005), pre-weight-loss BMI (p = 0.009), total weight loss (p = 0.007), WLP% (p = 0.008), BMI-R (p = 0.047), and WLPM (p = 0.046).Conclusions

Rapid or substantial WL is associated with more frequent sensory abnormalities in PNFH. Evaluating WL history and sensory nerve involvement may improve the clinical assessment of patients with PNFH.

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Cite

BibTeXRIS
BibTeX
@article{balduz2026association,
  title = {{Association between body weight reduction and electrodiagnostic findings in peroneal neuropathy at the fibular head.}},
  author = {Metin Balduz and U Cigdem Alaydin and Halit Fidancı and Mehmet Yıldız and Şencan Buturak and Zülfikar Arlıer},
  journal = {BMC neurology},
  year = {2026},
  month = aug,
  doi = {10.1186/s12883-026-05218-4},
  url = {https://europepmc.org/article/MED/42972278},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Association between body weight reduction and electrodiagnostic findings in peroneal neuropathy at the fibular head.
AU  - Metin Balduz
AU  - U Cigdem Alaydin
AU  - Halit Fidancı
AU  - Mehmet Yıldız
AU  - Şencan Buturak
AU  - Zülfikar Arlıer
PY  - 2026
DA  - 2026/08/05
JO  - BMC neurology
DO  - 10.1186/s12883-026-05218-4
UR  - https://europepmc.org/article/MED/42972278
AB  - Background  Peroneal neuropathy at the fibular head (PNFH) is often associated with recent weight loss (WL); however, it remains unclear how weight-loss characteristics are related to nerve involvement. This study aimed to investigate the relationship between WL characteristics and clinical and electrodiagnostic findings in patients with PNFH.Methods  Thirty-seven adults diagnosed with PNFH between October 2018 and June 2022 were retrospectively analyzed. Patients were divided into WL (n = 22) and non-WL (n = 15) groups. WL was defined as a ≥ 5% reduction in baseline body weight within one to six months. WL parameters included absolute WL, WL percentage (WLP%), WL per month (WLPM), and BMI reduction (BMI-R). Clinical and electrophysiological findings were compared between groups.Results  The mean WL was 21.5 ± 13.2 kg over a median of 3.5 months. Overall electrophysiological findings were similar between groups, except for a higher prevalence of abnormal superficial peroneal nerve conduction studies in the WL group (10/22 vs. 2/15, p = 0.043). Sensory nerve conduction velocity showed significant negative correlations with admission weight (p = 0.005), pre-weight-loss BMI (p = 0.009), total weight loss (p = 0.007), WLP% (p = 0.008), BMI-R (p = 0.047), and WLPM (p = 0.046).Conclusions  Rapid or substantial WL is associated with more frequent sensory abnormalities in PNFH. Evaluating WL history and sensory nerve involvement may improve the clinical assessment of patients with PNFH.
SN  - 1471-2377
ER  -