[Re] Computational Modelling of Glucose Uptake by SGLT1 and Apical GLUT2 in the Enterocyte
Abstract
This article is the reproduction of the computational model of glucose absorption by the enterocyte by Afshar et al. in 2021 and more precisely, the reproduction made by the authors themselves in 2023. The enterocyte is the main component of the intestinal barrier, that is the cell type transporting glucose from digested food in the intestine to the blood. To this day, the model from Afshar et al. is the most complete description of enterocyte absorption, defined in terms of ordinary differential equations for the glucose, the ionic species and other physical properties of the cell. This paper presents a complete reengineering and rewriting of this model in a different language, from CellML to Julia, with added comments and bibliography. We reproduce each figure of the original paper and comment on their meaning. Our reproduction is freely available with the following link and can be easily modified for reuse and modification of the model and its parameters. It should also be noted that Afshar et al. also inversed the sign of the paracellular flux of glucose but since the relative value of this flux is negligible compared to the fluxes through the cell, the difference is insignificant.
Related
- Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
- Beyond heartbeats: re-thinking interoception in autism through virtual reality and computational modelling
- Host-like temperature unlocks glucose uptake and metabolism in pathogenic Leptospira
- Computational modelling of acetylcholine deficiency-mediated dysfunction in the basal ganglia-thalamocortical network related to Parkinson’s disease dementia
- The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics
BibTeX
@article{raqbi2026computational,
title = {{[Re] Computational Modelling of Glucose Uptake by SGLT1 and Apical GLUT2 in the Enterocyte}},
author = {Karim Raqbi and Maxime Folschette and Cristian Versari and Olivier Briand and Cédric Lhoussaine},
journal = {The ReScience journal},
year = {2026},
month = jun,
doi = {10.5281/zenodo.20613595},
url = {https://hal.science/hal-05738530v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - [Re] Computational Modelling of Glucose Uptake by SGLT1 and Apical GLUT2 in the Enterocyte
AU - Karim Raqbi
AU - Maxime Folschette
AU - Cristian Versari
AU - Olivier Briand
AU - Cédric Lhoussaine
PY - 2026
DA - 2026/06/10
JO - The ReScience journal
DO - 10.5281/zenodo.20613595
UR - https://hal.science/hal-05738530v1
AB - This article is the reproduction of the computational model of glucose absorption by the enterocyte by Afshar et al. in 2021 and more precisely, the reproduction made by the authors themselves in 2023. The enterocyte is the main component of the intestinal barrier, that is the cell type transporting glucose from digested food in the intestine to the blood. To this day, the model from Afshar et al. is the most complete description of enterocyte absorption, defined in terms of ordinary differential equations for the glucose, the ionic species and other physical properties of the cell. This paper presents a complete reengineering and rewriting of this model in a different language, from CellML to Julia, with added comments and bibliography. We reproduce each figure of the original paper and comment on their meaning. Our reproduction is freely available with the following link and can be easily modified for reuse and modification of the model and its parameters. It should also be noted that Afshar et al. also inversed the sign of the paracellular flux of glucose but since the relative value of this flux is negligible compared to the fluxes through the cell, the difference is insignificant.
SN - 2430-3658
ER -