CSF turnover dysfunction: a hidden early biomarker in iRBD?
- 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School
- 2Department of Neurology, Massachusetts General Hospital and Harvard Medical School
Abstract
Evidence in Alzheimer’s disease and other dementias shows that changes in cerebrospinal fluid (CSF) turnover and perivascular spaces (PVS) volume are associated with disease progression through impairment of waste-clearance glymphatic pathways. Volume of CSF, PVS, and drainage structures such as venous sinus are mostly excluded in current MRI studies of premanifest synucleinopathy. Here, we used 7 Tesla MRI to investigate whether modifications in CSF, PVS, and venous sinus volumes occur in 18 prodromal synucleinopathy patients (namely isolated rapid-eye-movement sleep behavior disorder, iRBD) compared to 20 healthy young and 18 elderly controls. Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls. This suggests increased CSF and PVS fluid stasis, possibly due to impaired CSF filtration, a mechanism that could reduce glymphatic function and exacerbate the neurodegenerative process in iRBD.
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BibTeX
@article{grimaldi2026turnover,
title = {{CSF turnover dysfunction: a hidden early biomarker in iRBD?}},
author = {Stephan Grimaldi and Kavita Singh and María Guadalupe García-Gomar and Subhranil Koley and Firdaus Fabrice Hannanu and Ambra Stefani and Berkin Bilgic and Aleksandar Videnovic and Marta Bianciardi},
journal = {npj Parkinson's Disease},
year = {2026},
month = jul,
doi = {10.1038/s41531-026-01444-2},
url = {https://doi.org/10.1038/s41531-026-01444-2},
note = {CC BY},
}
RIS
TY - JOUR
TI - CSF turnover dysfunction: a hidden early biomarker in iRBD?
AU - Stephan Grimaldi
AU - Kavita Singh
AU - María Guadalupe García-Gomar
AU - Subhranil Koley
AU - Firdaus Fabrice Hannanu
AU - Ambra Stefani
AU - Berkin Bilgic
AU - Aleksandar Videnovic
AU - Marta Bianciardi
PY - 2026
DA - 2026/07/01
JO - npj Parkinson's Disease
DO - 10.1038/s41531-026-01444-2
UR - https://doi.org/10.1038/s41531-026-01444-2
AB - Evidence in Alzheimer’s disease and other dementias shows that changes in cerebrospinal fluid (CSF) turnover and perivascular spaces (PVS) volume are associated with disease progression through impairment of waste-clearance glymphatic pathways. Volume of CSF, PVS, and drainage structures such as venous sinus are mostly excluded in current MRI studies of premanifest synucleinopathy. Here, we used 7 Tesla MRI to investigate whether modifications in CSF, PVS, and venous sinus volumes occur in 18 prodromal synucleinopathy patients (namely isolated rapid-eye-movement sleep behavior disorder, iRBD) compared to 20 healthy young and 18 elderly controls. Our results demonstrated increased CSF and PVS volumes in iRBD without a matching increase in drainage venous structures, as observed in elderly controls. This suggests increased CSF and PVS fluid stasis, possibly due to impaired CSF filtration, a mechanism that could reduce glymphatic function and exacerbate the neurodegenerative process in iRBD.
SN - 2373-8057
ER -