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Peer-reviewedCC BYMedicine

Opsoclonus-myoclonus-ataxia syndrome in an elderly female : A video-based case report and literature review

  • Chi Meng1
  • Yan Li2
  • Siyuan Wen1
  • Feifei Chen1
  • Pan Tao1
  • Xin Kang1
  • Jing Huang1
  • Wei Chen1
  • Changqing Zhou1
  1. 1Department of Neurology, Bishan Hospital of Chongqing Medical University, Bishan, China
  2. 2Department of Intensive Care Unit, Bishan Hospital, Chonqqing University of Chinese Medicine, Chongqing, China.
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Abstract

Rationale:: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is rare in adults. Here, we report a rare case of OMAS in an elderly patient, accompanied by video documentation and a comprehensive literature review, which may offer valuable insights into the clinical features, diagnosis, and management of this condition.

Patient concerns:: An 81-year-old female was admitted with limb tremors lasting for 1 day. During the hospitalization, she developed opsoclonus, myoclonus, ataxia, behavioral changes, and sleep disturbances.

Diagnoses:: Laboratory and imaging findings were unremarkable, with no tumor detected during follow-up, supporting a diagnosis of idiopathic OMAS.

Interventions:: Immunotherapy consisted of steroids, while symptomatic treatment included clonazepam and gabapentin.

Outcomes:: The patient showed marked symptomatic improvement after immunotherapy. At two-year follow-up, there was no evidence of recurrence or malignancy.

Lessons:: In elderly patients, OMAS is extremely rare and often diagnosed and treated late. Comprehensive screening for malignancies and infectious triggers is critical. Early recognition and prompt immunotherapy improve outcomes.

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Cite

BibTeXRIS
BibTeX
@article{meng2026opsoclonusmyoclonusataxia,
  title = {{Opsoclonus-myoclonus-ataxia syndrome in an elderly female : A video-based case report and literature review}},
  author = {Chi Meng and Yan Li and Siyuan Wen and Feifei Chen and Pan Tao and Xin Kang and Jing Huang and Wei Chen and Changqing Zhou},
  journal = {Medicine},
  year = {2026},
  month = oct,
  doi = {10.1097/md.0000000000051387},
  url = {https://europepmc.org/article/PMC/PMC13727239},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Opsoclonus-myoclonus-ataxia syndrome in an elderly female : A video-based case report and literature review
AU  - Chi Meng
AU  - Yan Li
AU  - Siyuan Wen
AU  - Feifei Chen
AU  - Pan Tao
AU  - Xin Kang
AU  - Jing Huang
AU  - Wei Chen
AU  - Changqing Zhou
PY  - 2026
DA  - 2026/10/30
JO  - Medicine
DO  - 10.1097/md.0000000000051387
UR  - https://europepmc.org/article/PMC/PMC13727239
AB  - Rationale:: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is rare in adults. Here, we report a rare case of OMAS in an elderly patient, accompanied by video documentation and a comprehensive literature review, which may offer valuable insights into the clinical features, diagnosis, and management of this condition.  Patient concerns:: An 81-year-old female was admitted with limb tremors lasting for 1 day. During the hospitalization, she developed opsoclonus, myoclonus, ataxia, behavioral changes, and sleep disturbances.  Diagnoses:: Laboratory and imaging findings were unremarkable, with no tumor detected during follow-up, supporting a diagnosis of idiopathic OMAS.  Interventions:: Immunotherapy consisted of steroids, while symptomatic treatment included clonazepam and gabapentin.  Outcomes:: The patient showed marked symptomatic improvement after immunotherapy. At two-year follow-up, there was no evidence of recurrence or malignancy.  Lessons:: In elderly patients, OMAS is extremely rare and often diagnosed and treated late. Comprehensive screening for malignancies and infectious triggers is critical. Early recognition and prompt immunotherapy improve outcomes.
SN  - 0304-5412
SN  - 1536-5964
SN  - 0025-7974
ER  -