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Peer-reviewedCC BYDiseases (Basel, Switzerland)

Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.

  • Diana Iosif1,2
  • Viorel Gherghina2,3
  • Andra Iulia Suceveanu3,4
  • Cristian Ionut Orasanu5,6
  • Marius Dragos Prazaru1,2
  • Iulia Cindea2,3
  • Anca Pantea Stoian7,8
  • Laura Mazilu3,9
  • Alina Doina Nicoara3,4
  • Adrian Paul Suceveanu3,4
9 affiliations
  1. 1Doctoral School of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
  2. 2Department of Intensive Care Unit, "Sf. Apostol Andrei" Emergency County Hospital, 900591 Constanta, Romania.
  3. 3Faculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.
  4. 4Department of Gastroenterology, "Sf. Apostol Andrei" Emergency County Hospital, 900591 Constanta, Romania.
  5. 5Clinical Service of Pathology, Departments of Pathology, "Sf. Apostol Andrei" Emergency County Hospital, 900591 Constanta, Romania.
  6. 6Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology (CEDMOG), "Ovidius" University of Constanta, 900591 Constanta, Romania.
  7. 7Department of Diabetes, Nutrition and Metabolic Diseases, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  8. 8Department of Diabetes and Metabolic Diseases, "Prof. N.C. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 020475 Bucharest, Romania.
  9. 9Department of Oncology, Ovidius Clinical Hospital, 905900 Constanta, Romania.
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Abstract

Background/Objectives: Severe acute pancreatitis accounts for 20% of acute pancreatitis episodes and carries a substantial mortality risk. The systematic severity of the disease is driven by a massive cytokine release, with Interleukin-17 (IL-17) acting as a crucial modulator of the pro-inflammatory cascade. This study aimed to evaluate the prognostic value of serum IL-17 at admission and correlate it with multi-organ dysfunctions and clinical-biological outcomes in patients with severe acute pancreatitis. Methods: A retrospective analysis was conducted on a cohort of 35 patients with severe acute pancreatitis. Demographic, etiological, and clinical-biological baseline characteristics were extracted. Serum IL-17 levels were determined at admission using the ELISA method, and data were statistically analyzed. Results: Significantly higher levels of IL-17 were observed in patients who developed multi-organ failure. Prognostic thresholds were identified via ROC analysis to predict organ dysfunctions: ≥19.77 pg/mL for neurological dysfunction (AUC = 0.814, p = 0.003) and acute respiratory distress syndrome (AUC = 0.756, p = 0.024); ≥18.45 pg/mL for respiratory (p = 0.004) and cardiovascular dysfunctions (AUC = 0.820, p = 0.002); and ≥19.81 pg/mL for renal dysfunction (AUC = 0.735, p = 0.020). Furthermore, univariate binary logistic regression identified elevated serum IL-17 as a significant prognostic factor for mortality among patients admitted to the intensive care unit (OR = 1.062, p = 0.048). Conclusions: Serum IL-17 at admission functions as a significant prognostic biomarker that reflects the severe systemic pro-inflammatory status in severe acute pancreatitis and mirrors the risk of subsequent organ dysfunctions and mortality. Incorporating IL-17 into initial risk stratification protocols may assist clinicians in timely therapeutic escalation.

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Cite

BibTeXRIS
BibTeX
@article{iosif2026role,
  title = {{Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.}},
  author = {Diana Iosif and Viorel Gherghina and Andra Iulia Suceveanu and Cristian Ionut Orasanu and Marius Dragos Prazaru and Iulia Cindea and Anca Pantea Stoian and Laura Mazilu and Alina Doina Nicoara and Adrian Paul Suceveanu},
  journal = {Diseases (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/diseases14100351},
  url = {https://europepmc.org/article/MED/42929978},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Role of Interleukin 17 in Severe Acute Pancreatitis: Human Retrospective Pilot Study.
AU  - Diana Iosif
AU  - Viorel Gherghina
AU  - Andra Iulia Suceveanu
AU  - Cristian Ionut Orasanu
AU  - Marius Dragos Prazaru
AU  - Iulia Cindea
AU  - Anca Pantea Stoian
AU  - Laura Mazilu
AU  - Alina Doina Nicoara
AU  - Adrian Paul Suceveanu
PY  - 2026
DA  - 2026/09/23
JO  - Diseases (Basel, Switzerland)
DO  - 10.3390/diseases14100351
UR  - https://europepmc.org/article/MED/42929978
AB  - Background/Objectives: Severe acute pancreatitis accounts for 20% of acute pancreatitis episodes and carries a substantial mortality risk. The systematic severity of the disease is driven by a massive cytokine release, with Interleukin-17 (IL-17) acting as a crucial modulator of the pro-inflammatory cascade. This study aimed to evaluate the prognostic value of serum IL-17 at admission and correlate it with multi-organ dysfunctions and clinical-biological outcomes in patients with severe acute pancreatitis. Methods: A retrospective analysis was conducted on a cohort of 35 patients with severe acute pancreatitis. Demographic, etiological, and clinical-biological baseline characteristics were extracted. Serum IL-17 levels were determined at admission using the ELISA method, and data were statistically analyzed. Results: Significantly higher levels of IL-17 were observed in patients who developed multi-organ failure. Prognostic thresholds were identified via ROC analysis to predict organ dysfunctions: ≥19.77 pg/mL for neurological dysfunction (AUC = 0.814, p = 0.003) and acute respiratory distress syndrome (AUC = 0.756, p = 0.024); ≥18.45 pg/mL for respiratory (p = 0.004) and cardiovascular dysfunctions (AUC = 0.820, p = 0.002); and ≥19.81 pg/mL for renal dysfunction (AUC = 0.735, p = 0.020). Furthermore, univariate binary logistic regression identified elevated serum IL-17 as a significant prognostic factor for mortality among patients admitted to the intensive care unit (OR = 1.062, p = 0.048). Conclusions: Serum IL-17 at admission functions as a significant prognostic biomarker that reflects the severe systemic pro-inflammatory status in severe acute pancreatitis and mirrors the risk of subsequent organ dysfunctions and mortality. Incorporating IL-17 into initial risk stratification protocols may assist clinicians in timely therapeutic escalation.
SN  - 2079-9721
ER  -