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Peer-reviewedCC BY-NC 4.0Journal of Asthma and Allergy

Asthma and Impaired Sleep: Identifying Treatable Traits in the SCAPIS Study

  • Juan Wang1,2
  • Anders Blomberg3
  • Magnus Ekström4
  • Hans Lennart Persson5
  • Magnus Sköld6,7
  • Kjell Torén8,9
  • Ludger Grote10,11
  • Ding Zou12
  • Karl A Franklin13
  • Baz Delshad1
  • Xingwu Zhou1,2
  • Jenny Theorell-Haglöw1
3 more authors
  • Eva Lindberg1
  • Andrei Malinovschi2
  • Christer Janson1
13 affiliations
  1. 1Department of Medical Sciences, Respiratory-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden
  2. 2Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
  3. 3Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  4. 4Department of Clinical Sciences in Lund, Respiratory Medicine, Allergology and Palliative Medicine, Faculty of Medicine, Lund University, Lund, Sweden
  5. 5Department of Respiratory Medicine in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
  6. 6Department of Medicine Solna and Center for Molecular Medicine, Division of Immunology and Respiratory Medicine, Karolinska Institutet, Stockholm, Sweden
  7. 7Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden
  8. 8Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
  9. 9School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden
  10. 10Department for Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
  11. 11Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  12. 12Institute of Medicine, Center for Sleep and Vigilance Disorders, University of Gothenburg, Gothenburg, Sweden
  13. 13Department of Diagnostics and Intervention, Surgery, Umeå University, Umeå, Sweden
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Abstract

Introduction: This study compared sleep quality and insomnia symptoms in individuals with and without asthma and identified potentially treatable traits that could be used to improve sleep in asthma.

Methods: This cross-sectional analysis included 28,828 participants (aged 50–64). Post-bronchodilator forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured. Questionnaires assessed physician-diagnosed asthma, asthma-related symptoms, exacerbations, allergic rhinitis, chronic rhinosinusitis (CRS), nocturnal breathing disorders and reflux (snoring, sleep apnea, nocturnal gastroesophageal reflux [nGER]), and sleep quality. Insomnia symptoms included difficulties initiating sleep (DIS), difficulties maintaining sleep (DMS), and early morning awakening (EMA).

Results: Current asthma was associated with impaired sleep quality (OR=1.56; [95% CI:] 1.39–1.75), DIS (1.59; [1.40–1.81]), DMS (1.36; [1.22–1.51]), EMA (1.31; [1.16–1.48]), and any insomnia symptom (1.38; [1.25–1.52]). Among individuals with asthma, allergic rhinitis was linked to impaired sleep quality (1.28; [1.01–1.62]), while CRS, asthma symptoms, exacerbations, snoring, sleep apnea and nGER were associated with impaired sleep quality and insomnia symptoms. Those with uncontrolled asthma, CRS, or nocturnal breathing disorders and reflux had higher odds of impaired sleep quality and any insomnia symptom, with the strongest associations in those with all three conditions (5.68; [3.47–9.29] and 3.63; [2.26–5.85], respectively).

Conclusion: Asthma is associated with impaired sleep quality and insomnia symptoms in middle-aged adults. Our study also indicates that in asthma, impaired sleep quality and insomnia symptoms are linked to three potentially treatable traits, namely lack of asthma control, upper airway disorders, and nocturnal breathing disorders and reflux.

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Cite

BibTeXRIS
BibTeX
@article{wang2026asthma,
  title = {{Asthma and Impaired Sleep: Identifying Treatable Traits in the SCAPIS Study}},
  author = {Juan Wang and Anders Blomberg and Magnus Ekström and Hans Lennart Persson and Magnus Sköld and Kjell Torén and Ludger Grote and Ding Zou and Karl A Franklin and Baz Delshad and Xingwu Zhou and Jenny Theorell-Haglöw and Eva Lindberg and Andrei Malinovschi and Christer Janson},
  journal = {Journal of Asthma and Allergy},
  year = {2026},
  month = nov,
  doi = {10.2147/jaa.s639747},
  url = {https://doi.org/10.2147/jaa.s639747},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Asthma and Impaired Sleep: Identifying Treatable Traits in the SCAPIS Study
AU  - Juan Wang
AU  - Anders Blomberg
AU  - Magnus Ekström
AU  - Hans Lennart Persson
AU  - Magnus Sköld
AU  - Kjell Torén
AU  - Ludger Grote
AU  - Ding Zou
AU  - Karl A Franklin
AU  - Baz Delshad
AU  - Xingwu Zhou
AU  - Jenny Theorell-Haglöw
AU  - Eva Lindberg
AU  - Andrei Malinovschi
AU  - Christer Janson
PY  - 2026
DA  - 2026/11/01
JO  - Journal of Asthma and Allergy
DO  - 10.2147/jaa.s639747
UR  - https://doi.org/10.2147/jaa.s639747
AB  - Introduction: This study compared sleep quality and insomnia symptoms in individuals with and without asthma and identified potentially treatable traits that could be used to improve sleep in asthma.  Methods: This cross-sectional analysis included 28,828 participants (aged 50–64). Post-bronchodilator forced expiratory volume (FEV1) and forced vital capacity (FVC) were measured. Questionnaires assessed physician-diagnosed asthma, asthma-related symptoms, exacerbations, allergic rhinitis, chronic rhinosinusitis (CRS), nocturnal breathing disorders and reflux (snoring, sleep apnea, nocturnal gastroesophageal reflux [nGER]), and sleep quality. Insomnia symptoms included difficulties initiating sleep (DIS), difficulties maintaining sleep (DMS), and early morning awakening (EMA).  Results: Current asthma was associated with impaired sleep quality (OR=1.56; [95% CI:] 1.39–1.75), DIS (1.59; [1.40–1.81]), DMS (1.36; [1.22–1.51]), EMA (1.31; [1.16–1.48]), and any insomnia symptom (1.38; [1.25–1.52]). Among individuals with asthma, allergic rhinitis was linked to impaired sleep quality (1.28; [1.01–1.62]), while CRS, asthma symptoms, exacerbations, snoring, sleep apnea and nGER were associated with impaired sleep quality and insomnia symptoms. Those with uncontrolled asthma, CRS, or nocturnal breathing disorders and reflux had higher odds of impaired sleep quality and any insomnia symptom, with the strongest associations in those with all three conditions (5.68; [3.47–9.29] and 3.63; [2.26–5.85], respectively).  Conclusion: Asthma is associated with impaired sleep quality and insomnia symptoms in middle-aged adults. Our study also indicates that in asthma, impaired sleep quality and insomnia symptoms are linked to three potentially treatable traits, namely lack of asthma control, upper airway disorders, and nocturnal breathing disorders and reflux.
SN  - 1178-6965
ER  -