Outcomes in Pulmonary Arterial Hypertension: Results from a Single Center in Romania
5 affiliations
- 1Department of Pulmonology, “Carol Davila” University of Medicine and Pharmacy, 020022 Bucharest, Romania
- 2Department of Pulmonology, “Marius Nasta” Institute of Pulmonology, 050159 Bucharest, Romania
- 3Department of Cardiology, “Carol Davila” University of Medicine and Pharmacy, 020022 Bucharest, Romania
- 4Department of Cardiology, “C. C. Iliescu” Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania
- 5Cardiac Catheterization Laboratory, “C. C. Iliescu” Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania
Abstract
Background/Objectives: Real-world data on pulmonary arterial hypertension (PAH) in Romania are scarce. This study evaluated the clinical characteristics, long-term survival patterns and the prognostic utility of baseline variables in a Romanian PAH cohort. Methods: We retrospectively analyzed adult patients treated for PAH at a single expert center between 2007 and 2026. The primary outcome was a composite of all-cause mortality or lung transplantation. Survival was assessed using Kaplan–Meier and univariable Cox proportional-hazard regression models. Univariable and multivariable linear regressions were used to identify drivers of baseline estimated glomerular filtration rate (eGFR). Results: The primary analysis cohort included 75 patients (mean age 53 ± 15 years, 71% female). Overall transplant-free survival was unexpectedly high at 97.2%, 80.8%, and 66.7% at 1, 3, and 5 years, respectively. The European Society of Cardiology (ESC)/European Respiratory Society (ERS) 3-strata risk score did not stratify survival (log-rank p = 0.9). Significant predictors of adverse outcomes in univariable analysis included six-minute walking distance (6MWD), PAH etiology and baseline coronary artery disease. In univariable analysis, lower baseline eGFR was associated with age, hypertension and diabetes mellitus, but not with pulmonary hemodynamics or transplant-free survival. Conclusions: In this regional PAH cohort, survival rates were high, likely reflecting survivor bias stemming from delayed access to care. Adverse outcomes were associated with PAH etiology and 6MWD, but the limited number of events precluded multivariable analysis.
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BibTeX
@article{neagu2026outcomes,
title = {{Outcomes in Pulmonary Arterial Hypertension: Results from a Single Center in Romania}},
author = {Andrei Neagu and Ștefan Leu and Dragoș-Cosmin Zaharia and Claudia Lucia Toma and Roxana Enache and Daniel-Vlăduț Perpelea and Lucian Predescu and Pavel Platon and Miron Alexandru Bogdan and Tudor Constantinescu},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15207897},
url = {https://www.mdpi.com/2077-0383/15/20/7897},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Outcomes in Pulmonary Arterial Hypertension: Results from a Single Center in Romania
AU - Andrei Neagu
AU - Ștefan Leu
AU - Dragoș-Cosmin Zaharia
AU - Claudia Lucia Toma
AU - Roxana Enache
AU - Daniel-Vlăduț Perpelea
AU - Lucian Predescu
AU - Pavel Platon
AU - Miron Alexandru Bogdan
AU - Tudor Constantinescu
PY - 2026
DA - 2026/10/01
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15207897
UR - https://www.mdpi.com/2077-0383/15/20/7897
AB - Background/Objectives: Real-world data on pulmonary arterial hypertension (PAH) in Romania are scarce. This study evaluated the clinical characteristics, long-term survival patterns and the prognostic utility of baseline variables in a Romanian PAH cohort. Methods: We retrospectively analyzed adult patients treated for PAH at a single expert center between 2007 and 2026. The primary outcome was a composite of all-cause mortality or lung transplantation. Survival was assessed using Kaplan–Meier and univariable Cox proportional-hazard regression models. Univariable and multivariable linear regressions were used to identify drivers of baseline estimated glomerular filtration rate (eGFR). Results: The primary analysis cohort included 75 patients (mean age 53 ± 15 years, 71% female). Overall transplant-free survival was unexpectedly high at 97.2%, 80.8%, and 66.7% at 1, 3, and 5 years, respectively. The European Society of Cardiology (ESC)/European Respiratory Society (ERS) 3-strata risk score did not stratify survival (log-rank p = 0.9). Significant predictors of adverse outcomes in univariable analysis included six-minute walking distance (6MWD), PAH etiology and baseline coronary artery disease. In univariable analysis, lower baseline eGFR was associated with age, hypertension and diabetes mellitus, but not with pulmonary hemodynamics or transplant-free survival. Conclusions: In this regional PAH cohort, survival rates were high, likely reflecting survivor bias stemming from delayed access to care. Adverse outcomes were associated with PAH etiology and 6MWD, but the limited number of events precluded multivariable analysis.
SN - 2077-0383
ER -