Skip to content
DraconiticResearch
Search Sources API
197,578 studies31 sourcesUpdated 48 min ago
Peer-reviewedCC BY 4.0International Journal of Molecular Sciences

Intrafollicular PAI-1 Expression Is Associated with Absence of Histological Transformation During Long-Term Follow-Up in Follicular Lymphoma

  • Cecilie Dohrmann1,2
  • Marie Hairing Enemark1,2
  • Caroline Maren Stengaard Jensen1,2
  • Kristina Lystlund Lauridsen3
  • Trine Lindhardt Plesner4
  • Stephen Jacques Hamilton-Dutoit3
  • Maja Ludvigsen1,2
4 affiliations
  1. 1Department of Haematology, Aarhus University Hospital, 8200 Aarhus, Denmark
  2. 2Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark
  3. 3Department of Pathology, Aarhus University Hospital, 8200 Aarhus, Denmark
  4. 4Department of Pathology, Copenhagen University Hospital, 2100 Copenhagen, Denmark
Read full textPDFDOICite

Abstract

Follicular lymphoma (FL) is an indolent B-cell malignancy typically associated with favourable outcomes and prolonged survival. However, histological transformation (HT) occurs in a subset of patients and significantly worsens survival outcomes, markedly altering the disease course. Currently, no clinical or molecular predictors of HT are available. We sought to evaluate the potential of Serpin family E member 1 (PAI-1) as a prognostic biomarker of HT in FL, with expression levels assessed by immunohistochemistry and quantified using digital image analysis. PAI-1 expression was evaluated in diagnostic lymphoma biopsies from 30 FL patients with no record of subsequent HT with a minimum follow-up of 10 years, ranging from 10.1 to 24.8 years (non-transforming FL, nt-FL), and 18 patients with subsequent HT occurring 0.7 to 14.6 years after diagnosis (subsequently transforming FL, st-FL); furthermore, the paired high-grade biopsy from the time of HT (transformed FL, tFL) was included. No significant differential expression patterns were identified comparing nt-FL, st-FL and tFL samples. However, high intrafollicular PAI-1 expression at FL diagnosis correlated with no transformation events observed. We believe high intrafollicular PAI-1 expression at presentation might define a minor subgroup of FL patients with reduced risk of HT.

Related

  1. Toll-like receptor expression across histological states of Epidermodysplasia Verruciformis
    L. A. R. Froes Junior, C. C. d. A. Pereira, L. L. d. C. Silva +4
    bioRxivPreprintCC BYFull textEpidemiology & public healthbioRxiv
  2. Toll-like receptor expression across histological states of epidermodysplasia verruciformis.
    Luis Alberto Ribeiro Fróes, Cibele Conceição Dos Apóstolos Pereira, Lana Luiza da Cruz Silva +4
    Histochemistry and cell biologyPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMC
  3. Immunohistochemical Expression of Proliferating Cell Nuclear Antigen in Invasive Breast Carcinoma: Associations With Histological Grade and Ki-67 Expression.
    Vikash Kumar, Amresh Kumar, Namita Singh +2
    CureusPeer-reviewedCC BYFull textOncologyEurope PMC
  4. Chronic Energy Restriction Is Associated with Impaired Follicular Development and Hepatic Bile Acid Remodeling in Mice.
    Wenjun Zhu, Jiahao Li, Xiaochan Cheng +4
    Animals : an open access journal from MDPIPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMC
  5. Dynamic Ovarian Lymphatic Remodeling Is Associated with Macrophage Accumulation During Follicular Development and Ovulation in Mice
    Chuqing Wu, Dan Chen, Weicheng Tang +4
    BiomoleculesPeer-reviewedCC BY 4.0Full textOncologyCrossrefEurope PMC

Cite

BibTeXRIS
BibTeX
@article{dohrmann2026intrafollicular,
  title = {{Intrafollicular PAI-1 Expression Is Associated with Absence of Histological Transformation During Long-Term Follow-Up in Follicular Lymphoma}},
  author = {Cecilie Dohrmann and Marie Hairing Enemark and Caroline Maren Stengaard Jensen and Kristina Lystlund Lauridsen and Trine Lindhardt Plesner and Stephen Jacques Hamilton-Dutoit and Maja Ludvigsen},
  journal = {International Journal of Molecular Sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27198814},
  url = {https://www.mdpi.com/1422-0067/27/19/8814},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Intrafollicular PAI-1 Expression Is Associated with Absence of Histological Transformation During Long-Term Follow-Up in Follicular Lymphoma
AU  - Cecilie Dohrmann
AU  - Marie Hairing Enemark
AU  - Caroline Maren Stengaard Jensen
AU  - Kristina Lystlund Lauridsen
AU  - Trine Lindhardt Plesner
AU  - Stephen Jacques Hamilton-Dutoit
AU  - Maja Ludvigsen
PY  - 2026
DA  - 2026/10/01
JO  - International Journal of Molecular Sciences
DO  - 10.3390/ijms27198814
UR  - https://www.mdpi.com/1422-0067/27/19/8814
AB  - Follicular lymphoma (FL) is an indolent B-cell malignancy typically associated with favourable outcomes and prolonged survival. However, histological transformation (HT) occurs in a subset of patients and significantly worsens survival outcomes, markedly altering the disease course. Currently, no clinical or molecular predictors of HT are available. We sought to evaluate the potential of Serpin family E member 1 (PAI-1) as a prognostic biomarker of HT in FL, with expression levels assessed by immunohistochemistry and quantified using digital image analysis. PAI-1 expression was evaluated in diagnostic lymphoma biopsies from 30 FL patients with no record of subsequent HT with a minimum follow-up of 10 years, ranging from 10.1 to 24.8 years (non-transforming FL, nt-FL), and 18 patients with subsequent HT occurring 0.7 to 14.6 years after diagnosis (subsequently transforming FL, st-FL); furthermore, the paired high-grade biopsy from the time of HT (transformed FL, tFL) was included. No significant differential expression patterns were identified comparing nt-FL, st-FL and tFL samples. However, high intrafollicular PAI-1 expression at FL diagnosis correlated with no transformation events observed. We believe high intrafollicular PAI-1 expression at presentation might define a minor subgroup of FL patients with reduced risk of HT.
SN  - 1422-0067
ER  -