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Peer-reviewedCC BY-NC-NDKidney International Reports

Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus

  • Guy Rostoker
  • Antoine Lanot
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Abstract

Chronic kidney disease (CKD) associated pruritus (CKD-aP) is a very common condition in end-stage kidney disease under dialysis, affecting up to a third of the patients worldwide,1-2 with a significant impact of their quality of life.3 Until recently, therapeutic solutions were scarce and not very effective.4 The pathogenesis of CKD-aP is multifactorial, involving the accumulation of uremic toxins and inflammatory mediators, abnormal peripheral nerve conduction, and an imbalance between peripheral Mu opioid receptors (MORs) and Kappa opioid receptors (KORs).

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Cite

BibTeXRIS
BibTeX
@article{rostoker2026contrasting,
  title = {{Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus}},
  author = {Guy Rostoker and Antoine Lanot},
  journal = {Kidney International Reports},
  year = {2026},
  month = sep,
  doi = {10.1016/j.ekir.2024.01.019},
  url = {https://hal.science/hal-05746191v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Contrasting Evolution After Withdrawal of Long-Term Administration of Difelikefalin for CKD-Associated Pruritus
AU  - Guy Rostoker
AU  - Antoine Lanot
PY  - 2026
DA  - 2026/09/11
JO  - Kidney International Reports
DO  - 10.1016/j.ekir.2024.01.019
UR  - https://hal.science/hal-05746191v1
AB  - Chronic kidney disease (CKD) associated pruritus (CKD-aP) is a very common condition in end-stage kidney disease under dialysis, affecting up to a third of the patients worldwide,1-2 with a significant impact of their quality of life.3 Until recently, therapeutic solutions were scarce and not very effective.4 The pathogenesis of CKD-aP is multifactorial, involving the accumulation of uremic toxins and inflammatory mediators, abnormal peripheral nerve conduction, and an imbalance between peripheral Mu opioid receptors (MORs) and Kappa opioid receptors (KORs).
SN  - 2468-0249
ER  -