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Peer-reviewedCC BYCase reports in immunology

Identification of a Candidate IgE-Binding Maize Protein in a Patient With Corn-Dependent Exercise-Induced Anaphylaxis: A Case Report.

  • Ayako Goto1
  • Nobue Takamatsu2
  • Tatsuya Moriyama3
  • Yasuto Kondo4
  • Shinichiro Nagamitsu1
4 affiliations
  1. 1Department of Pediatrics School of Medicine Fukuoka University Fukuoka Japan fukuoka-u.ac.jp.
  2. 2Department of Food and Nutrition Beppu University Oita Japan.
  3. 3Department of Applied Cell Biology Graduate School of Agriculture Kindai University Nara Japan kindai.ac.jp.
  4. 4Department of Pediatrics Fujita Health University Bantane Hospital Nagoya Japan.
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Abstract

Corn-dependent exercise-induced anaphylaxis (food-dependent exercise-induced anaphylaxis [FDEIA]) is rare, and its causative allergens remain poorly defined. Here, we report a case of corn-dependent FDEIA and investigate candidate IgE-binding proteins using immunological and proteomic analyses. A 13-year-old boy with a history of buckwheat allergy developed recurrent anaphylaxis during exercise after ingesting corn-containing foods. An exercise challenge after ingesting 272 g of sweet corn reproduced the symptoms and confirmed the diagnosis. Corn-specific IgE was 3.72 UA/mL, and skin prick testing was positive. IgE immunoblotting revealed patient-specific bands at ~45 and 60 kDa. Two-dimensional immunoblotting and mass spectrometry identified globulin-1S (GLB1) and other proteins as candidate IgE-binding proteins in this patient. Sequence analysis revealed significant local sequence similarity between maize GLB1 and buckwheat Fag e 5 within the second cupin domain. These findings identify GLB1 as a candidate IgE-binding protein in this patient with corn-dependent FDEIA. Although sequence similarities were observed between maize GLB1 and buckwheat Fag e 5, their immunological and clinical significance remains unclear, and further studies are required to determine whether cross-reactivity exists.

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Cite

BibTeXRIS
BibTeX
@article{goto2026identification,
  title = {{Identification of a Candidate IgE-Binding Maize Protein in a Patient With Corn-Dependent Exercise-Induced Anaphylaxis: A Case Report.}},
  author = {Ayako Goto and Nobue Takamatsu and Tatsuya Moriyama and Yasuto Kondo and Shinichiro Nagamitsu},
  journal = {Case reports in immunology},
  year = {2026},
  month = oct,
  doi = {10.1155/crii/2731365},
  url = {https://europepmc.org/article/MED/42898784},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Identification of a Candidate IgE-Binding Maize Protein in a Patient With Corn-Dependent Exercise-Induced Anaphylaxis: A Case Report.
AU  - Ayako Goto
AU  - Nobue Takamatsu
AU  - Tatsuya Moriyama
AU  - Yasuto Kondo
AU  - Shinichiro Nagamitsu
PY  - 2026
DA  - 2026/10/19
JO  - Case reports in immunology
DO  - 10.1155/crii/2731365
UR  - https://europepmc.org/article/MED/42898784
AB  - Corn-dependent exercise-induced anaphylaxis (food-dependent exercise-induced anaphylaxis [FDEIA]) is rare, and its causative allergens remain poorly defined. Here, we report a case of corn-dependent FDEIA and investigate candidate IgE-binding proteins using immunological and proteomic analyses. A 13-year-old boy with a history of buckwheat allergy developed recurrent anaphylaxis during exercise after ingesting corn-containing foods. An exercise challenge after ingesting 272 g of sweet corn reproduced the symptoms and confirmed the diagnosis. Corn-specific IgE was 3.72 UA/mL, and skin prick testing was positive. IgE immunoblotting revealed patient-specific bands at ~45 and 60 kDa. Two-dimensional immunoblotting and mass spectrometry identified globulin-1S (GLB1) and other proteins as candidate IgE-binding proteins in this patient. Sequence analysis revealed significant local sequence similarity between maize GLB1 and buckwheat Fag e 5 within the second cupin domain. These findings identify GLB1 as a candidate IgE-binding protein in this patient with corn-dependent FDEIA. Although sequence similarities were observed between maize GLB1 and buckwheat Fag e 5, their immunological and clinical significance remains unclear, and further studies are required to determine whether cross-reactivity exists.
SN  - 2090-6609
SN  - 2090-6617
ER  -