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Peer-reviewedLicence not statedNature Genetics

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis

  • Matthew G. Jones1,2,3,4
  • Dawei Sun5,6,7
  • Kyung Hoi Min2,8,9,10
  • William N. Colgan1,2,11,9,12
  • Haoyu Wang13,14,15
  • Tivadar Torok5,7
  • Juliano Ribeiro1,3,16
  • Jessie Xue13,14,12
  • Erik C. Cardoso17,18,12
  • Yao Rong13,14,10
  • Luyi Tian5,19,20
  • Jackson A. Weir21,5,6,4
22 more authors
  • Victor Z. Chen13,14,7
  • Luke W. Koblan1,2,11,9,10
  • Kathryn E. Yost1,2,11,9,4
  • Nicolas Mathey‐Andrews1,2,22,10
  • Edridge K. D’Souza23,24,7
  • Andrew J. C. Russell5,12
  • Robert R. Stickels5,25
  • Karol S. Balderrama5,16
  • William M. Rideout1
  • Min Dai26,27
  • Giovanni J. Marrero5
  • Vipin Kumar5
  • Anjali Saqi28
  • Benjamin Herzberg23,28,24
  • Benjamin Izar29,23,14,24
  • Howard Y. Chang30,31,32
  • Joo‐Hyeon Lee17,18
  • Tyler Jacks1,2
  • Fei Chen33,34
  • Jonathan S. Weissman35,36,37,38
  • Nir Yosef39
  • Dian Yang40
40 affiliations
  1. 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  2. 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
  3. 3Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA
  4. 4Stanford University
  5. 5Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
  6. 6Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA
  7. 7Broad Institute of MIT and Harvard
  8. 8Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
  9. 9Whitehead Institute for Biomedical Research, Cambridge, MA, USA
  10. 10Massachusetts Institute of Technology
  11. 11Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA
  12. 12Whitehead Institute for Biomedical Research
  13. 13Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA
  14. 14Department of Systems Biology, Columbia University, New York, NY, USA
  15. 15Guangzhou National Laboratory
  16. 16Columbia University
  17. 17Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK
  18. 18Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
  19. 19Guangzhou National Laboratory, Guangzhou, China
  20. 20Broad Institute of Harvard and MIT
  21. 21Biological and Biomedical Sciences Program, Harvard University, Cambridge, MA, USA
  22. 22Harvard Medical School, Boston, MA, USA
  23. 23Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA
  24. 24Vagelos College of Physicians and Surgeons, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA
  25. 25Weizmann Institute of Science
  26. 26Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA
  27. 27Stanley Center for Psychiatric Research, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
  28. 28Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA
  29. 29Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA
  30. 30Amgen Research, San Francisco, CA, USA
  31. 31Department of Genetics, Stanford University, Stanford, CA, USA
  32. 32Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
  33. 33Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. [email protected]
  34. 34Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. [email protected]
  35. 35David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected]
  36. 36Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected]
  37. 37Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. [email protected]
  38. 38Whitehead Institute for Biomedical Research, Cambridge, MA, USA. [email protected]
  39. 39Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel. [email protected]
  40. 40Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, USA. [email protected]
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{jones2026spatiotemporal,
  title = {{Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis}},
  author = {Matthew G. Jones and Dawei Sun and Kyung Hoi Min and William N. Colgan and Haoyu Wang and Tivadar Torok and Juliano Ribeiro and Jessie Xue and Erik C. Cardoso and Yao Rong and Luyi Tian and Jackson A. Weir and Victor Z. Chen and Luke W. Koblan and Kathryn E. Yost and Nicolas Mathey‐Andrews and Edridge K. D’Souza and Andrew J. C. Russell and Robert R. Stickels and Karol S. Balderrama and William M. Rideout and Min Dai and Giovanni J. Marrero and Vipin Kumar and Anjali Saqi and Benjamin Herzberg and Benjamin Izar and Howard Y. Chang and Joo‐Hyeon Lee and Tyler Jacks and Fei Chen and Jonathan S. Weissman and Nir Yosef and Dian Yang},
  journal = {Nature Genetics},
  year = {2026},
  month = sep,
  doi = {10.1038/s41588-026-02739-z},
  url = {https://doi.org/10.1101/2024.10.21.619529},
}
RIS
TY  - JOUR
TI  - Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis
AU  - Matthew G. Jones
AU  - Dawei Sun
AU  - Kyung Hoi Min
AU  - William N. Colgan
AU  - Haoyu Wang
AU  - Tivadar Torok
AU  - Juliano Ribeiro
AU  - Jessie Xue
AU  - Erik C. Cardoso
AU  - Yao Rong
AU  - Luyi Tian
AU  - Jackson A. Weir
AU  - Victor Z. Chen
AU  - Luke W. Koblan
AU  - Kathryn E. Yost
AU  - Nicolas Mathey‐Andrews
AU  - Edridge K. D’Souza
AU  - Andrew J. C. Russell
AU  - Robert R. Stickels
AU  - Karol S. Balderrama
AU  - William M. Rideout
AU  - Min Dai
AU  - Giovanni J. Marrero
AU  - Vipin Kumar
AU  - Anjali Saqi
AU  - Benjamin Herzberg
AU  - Benjamin Izar
AU  - Howard Y. Chang
AU  - Joo‐Hyeon Lee
AU  - Tyler Jacks
AU  - Fei Chen
AU  - Jonathan S. Weissman
AU  - Nir Yosef
AU  - Dian Yang
PY  - 2026
DA  - 2026/09/01
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02739-z
UR  - https://doi.org/10.1101/2024.10.21.619529
SN  - 1061-4036
SN  - 1546-1718
ER  -