Targeting health-related quality of life issues not found with functional outcome measures a year after aneurysm subarachnoid hemorrhage in a Swedish national cohort.
7 affiliations
- 1Department of Clinical Sciences - Neurosciences, Umeå University, 901 87, Umeå, Sweden. [email protected].
- 2Department of Clinical Sciences - Neurosurgery, Lund University, Lund, Sweden.
- 3Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
- 4Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
- 5Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
- 6Department of Clinical Sciences, Linköping University, Linköping, Sweden.
- 7Department of Clinical Sciences - Neurosciences, Umeå University, 901 87, Umeå, Sweden.
Abstract
Purpose
Outcome after aneurysmal subarachnoid hemorrhage (aSAH) is often devastating with life time issues also for independent survivors. We aimed to identify health related quality of life (HRQoL) issues in this favorable functional outcome group compared to a sex and age matched general population.Methods
We have analyzed data from 634 Swedish aSAH patients from a national prospective study ranging between 2014 and 2018. One year after ictus, functional outcome was analyzed using Glasgow Outcome Scale Extended (GOSE) and HRQoL assessed by Euro-quality of life-5 dimensions-3 levels (EQ-5D-3L). Favorable GOSE (5-8) were found in 471 patients. Age- and sex-matched populations were created by published data from a cross-sectional cohort of 32,597 people living in Stockholm County in 2006. Odds ratios (ORs) for rating a specific EQ-5D-3L level were calculated for each domain. Significance was set at α = 0.001.Results
Patients reported less mobility problems than the matched general population (9.6% vs 14.7%; OR 0.62 p = 0.002). However, with usual activities significantly more difficulties with moderate, (24.0% vs 10.9%; OR 2.58, p < .001) and any problems (27.0% vs 12.5%; OR 2.58, p < .001) were reported. More issues with extreme anxiety/depression were also reported ((5.3% vs 2.8%; OR 1.94; p = 0.002). Unfavorable GOSE patients were doing worse than the matched population in all levels and dimensions measured (Online Resource 1, 2, 3 and 4).Conclusion
Although patients with favorable functional outcome report good or better mobility compared to their age and sex matched general population, they have significantly more issues with usual activities a year after aSAH more extreme issues with anxiety/depression were also reported To our knowledge, this is the first time EQ-5D-3L data is compared in a national group of aSAH patients with favorable functional outcome to a sex and age matched general population.
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BibTeX
@article{aineskog2026targeting,
title = {{Targeting health-related quality of life issues not found with functional outcome measures a year after aneurysm subarachnoid hemorrhage in a Swedish national cohort.}},
author = {Helena Aineskog and Bryndís Baldvinsdóttir and Ola G Nilsson and Asgeir S Jakola and Erik Kronvall and Elisabeth Ronne Engström and Paula Klurfan and Peter Alpkvist and Mikael Svensson and Jan Hillman and Peter Lindvall},
journal = {Acta neurochirurgica},
year = {2026},
month = oct,
doi = {10.1007/s00701-026-07059-z},
url = {https://europepmc.org/article/MED/42891758},
note = {CC BY},
}
RIS
TY - JOUR
TI - Targeting health-related quality of life issues not found with functional outcome measures a year after aneurysm subarachnoid hemorrhage in a Swedish national cohort.
AU - Helena Aineskog
AU - Bryndís Baldvinsdóttir
AU - Ola G Nilsson
AU - Asgeir S Jakola
AU - Erik Kronvall
AU - Elisabeth Ronne Engström
AU - Paula Klurfan
AU - Peter Alpkvist
AU - Mikael Svensson
AU - Jan Hillman
AU - Peter Lindvall
PY - 2026
DA - 2026/10/16
JO - Acta neurochirurgica
DO - 10.1007/s00701-026-07059-z
UR - https://europepmc.org/article/MED/42891758
AB - Purpose Outcome after aneurysmal subarachnoid hemorrhage (aSAH) is often devastating with life time issues also for independent survivors. We aimed to identify health related quality of life (HRQoL) issues in this favorable functional outcome group compared to a sex and age matched general population.Methods We have analyzed data from 634 Swedish aSAH patients from a national prospective study ranging between 2014 and 2018. One year after ictus, functional outcome was analyzed using Glasgow Outcome Scale Extended (GOSE) and HRQoL assessed by Euro-quality of life-5 dimensions-3 levels (EQ-5D-3L). Favorable GOSE (5-8) were found in 471 patients. Age- and sex-matched populations were created by published data from a cross-sectional cohort of 32,597 people living in Stockholm County in 2006. Odds ratios (ORs) for rating a specific EQ-5D-3L level were calculated for each domain. Significance was set at α = 0.001.Results Patients reported less mobility problems than the matched general population (9.6% vs 14.7%; OR 0.62 p = 0.002). However, with usual activities significantly more difficulties with moderate, (24.0% vs 10.9%; OR 2.58, p < .001) and any problems (27.0% vs 12.5%; OR 2.58, p < .001) were reported. More issues with extreme anxiety/depression were also reported ((5.3% vs 2.8%; OR 1.94; p = 0.002). Unfavorable GOSE patients were doing worse than the matched population in all levels and dimensions measured (Online Resource 1, 2, 3 and 4).Conclusion Although patients with favorable functional outcome report good or better mobility compared to their age and sex matched general population, they have significantly more issues with usual activities a year after aSAH more extreme issues with anxiety/depression were also reported To our knowledge, this is the first time EQ-5D-3L data is compared in a national group of aSAH patients with favorable functional outcome to a sex and age matched general population.
SN - 0001-6268
SN - 0942-0940
ER -