Association between mean airway pressure and 90-day mortality in ventilator-associated pneumonia
- 1Shenzhen Luohu Hospital Group
- 2Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine
Abstract
Objective We performed a retrospective cohort analysis to assess the association between mean airway pressure (Pmean) during mechanical ventilation and 90-day mortality in patients with ventilator-associated pneumonia (VAP). Results Of the 2,911 VAP cases retrieved from MIMIC-IV, 693 patients (23.8%) had died within 90 days. Non-survivors showed a significantly higher average Pmean than survivors (median [IQR]:10.80 [8.85, 13.89] vs. 9.89 [8.28, 12.04]; P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for average Pmean was 0.591. When patients were divided by median Pmean (10.06 cmH₂O), those with higher values had worse 90-day survival (log-rank P < 0.001). Conclusions Higher average Pmean was associated with increased 90-day mortality in VAP. These univariable results suggest an association, but validation with multivariable and prospective studies is needed.
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BibTeX
@article{huang2026association,
title = {{Association between mean airway pressure and 90-day mortality in ventilator-associated pneumonia}},
author = {Hai Huang and Aihua Wang and Wenzhen Wu},
journal = {The Egyptian Journal of Bronchology},
year = {2026},
month = oct,
doi = {10.1186/s43168-026-00707-z},
url = {https://doi.org/10.1186/s43168-026-00707-z},
note = {CC BY},
}
RIS
TY - JOUR
TI - Association between mean airway pressure and 90-day mortality in ventilator-associated pneumonia
AU - Hai Huang
AU - Aihua Wang
AU - Wenzhen Wu
PY - 2026
DA - 2026/10/25
JO - The Egyptian Journal of Bronchology
DO - 10.1186/s43168-026-00707-z
UR - https://doi.org/10.1186/s43168-026-00707-z
AB - Objective We performed a retrospective cohort analysis to assess the association between mean airway pressure (Pmean) during mechanical ventilation and 90-day mortality in patients with ventilator-associated pneumonia (VAP). Results Of the 2,911 VAP cases retrieved from MIMIC-IV, 693 patients (23.8%) had died within 90 days. Non-survivors showed a significantly higher average Pmean than survivors (median [IQR]:10.80 [8.85, 13.89] vs. 9.89 [8.28, 12.04]; P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for average Pmean was 0.591. When patients were divided by median Pmean (10.06 cmH₂O), those with higher values had worse 90-day survival (log-rank P < 0.001). Conclusions Higher average Pmean was associated with increased 90-day mortality in VAP. These univariable results suggest an association, but validation with multivariable and prospective studies is needed.
SN - 1687-8426
SN - 2314-8551
ER -