Diagnostic criteria for adrenal overt Cushing syndrome: prepared jointly by the Japan Endocrine Society and the Health and Labour Sciences Research Grant (Research on Intractable Diseases) Research Group on Disorders of Adrenal Hormones
Abstract
Adrenal overt Cushing syndrome (CS) is a rare disease but presents with a high risk of serious, life-threatening complications. Although florid CS is less frequently reported now, the interval between symptom onset and diagnosis still remains as long as four years. In this study, we investigated the current status of patients presenting with adrenal overt CS in the 2000s using data from the "Study of Advancing Care and Pathogenesis of Intractable Adrenal Diseases in Japan (ACPA-J study)." Based on the findings, we have established the diagnostic criteria for adrenal overt CS through the deliberation with members of the Health and Labour Sciences Research Grant "Research group on Disorders of adrenal hormones" and the public comment process conducted by the Japan Endocrine Society. We expect these diagnostic criteria to facilitate the designation of adrenal overt CS as an intractable disease and enhance standards of care.
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BibTeX
@article{katabami2026diagnostic,
title = {{Diagnostic criteria for adrenal overt Cushing syndrome: prepared jointly by the Japan Endocrine Society and the Health and Labour Sciences Research Grant (Research on Intractable Diseases) Research Group on Disorders of Adrenal Hormones}},
author = {Takuyuki Katabami and Hirotaka Shibata and Akiyo Tanabe and Masakatsu Sone and Michio Otsuki and Yoshihiro Ogawa and Tomoatsu Mune and Takamasa Ichijo and Yuichi Yoshida and Takashi Yoneda and Kazuhiko Horiguchi and Katsutoshi Takahashi and Mitsuru Nishiyama and Fumitoshi Sato and Isao Kurihara and Makito Tanabe and Toshihiro Tajima and Tomonobu Hasegawa and Tomohiro Ishii},
journal = {Endocrine Journal},
year = {2026},
month = jul,
doi = {10.1507/endocrj.ej26-0077},
url = {https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0077/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Diagnostic criteria for adrenal overt Cushing syndrome: prepared jointly by the Japan Endocrine Society and the Health and Labour Sciences Research Grant (Research on Intractable Diseases) Research Group on Disorders of Adrenal Hormones
AU - Takuyuki Katabami
AU - Hirotaka Shibata
AU - Akiyo Tanabe
AU - Masakatsu Sone
AU - Michio Otsuki
AU - Yoshihiro Ogawa
AU - Tomoatsu Mune
AU - Takamasa Ichijo
AU - Yuichi Yoshida
AU - Takashi Yoneda
AU - Kazuhiko Horiguchi
AU - Katsutoshi Takahashi
AU - Mitsuru Nishiyama
AU - Fumitoshi Sato
AU - Isao Kurihara
AU - Makito Tanabe
AU - Toshihiro Tajima
AU - Tomonobu Hasegawa
AU - Tomohiro Ishii
PY - 2026
DA - 2026/07/07
JO - Endocrine Journal
DO - 10.1507/endocrj.ej26-0077
UR - https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ26-0077/_article
AB - Adrenal overt Cushing syndrome (CS) is a rare disease but presents with a high risk of serious, life-threatening complications. Although florid CS is less frequently reported now, the interval between symptom onset and diagnosis still remains as long as four years. In this study, we investigated the current status of patients presenting with adrenal overt CS in the 2000s using data from the "Study of Advancing Care and Pathogenesis of Intractable Adrenal Diseases in Japan (ACPA-J study)." Based on the findings, we have established the diagnostic criteria for adrenal overt CS through the deliberation with members of the Health and Labour Sciences Research Grant "Research group on Disorders of adrenal hormones" and the public comment process conducted by the Japan Endocrine Society. We expect these diagnostic criteria to facilitate the designation of adrenal overt CS as an intractable disease and enhance standards of care.
SN - 1348-4540
SN - 0918-8959
ER -