Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 44 min ago
Peer-reviewedCC BY 4.0Frontiers in Medicine

Factors associated with early puncture-site wound events after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a retrospective cohort study

  • Xiangle He1,2
  • Changzhi Huang1,2
  • Bingqian Zheng1,3
  • Xianliang Wu1,2
  • Chengguo Huang4
  • Shuqiang Lu4
  • Yufeng Huang1,2
  • Jinghan Chen1,2
  • Jianjun Huang1,2
  • Bei Li1,2
4 affiliations
  1. 1Ningde Clinical Medical College of Fujian Medical University, Ningde, China
  2. 2Department of Orthopedics, Ningde Municipal Hospital, Ningde, China
  3. 3Department of Rehabilitation Medicine, Ningde Municipal Hospital, Ningde, China
  4. 4Department of Orthopedics, Pingnan County Hospital, Ningde, China
Read full textPDFDOICite

Abstract

Objective: Early puncture-site wound events after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) often receive less attention than major complications, but they may influence early wound monitoring and postoperative risk assessment. This study aimed to identify factors associated with early puncture-site wound events after elective PVP.

Methods: This single-center retrospective cohort study included consecutive patients who underwent elective PVP for OVCFs between January 2022 and June 2026. The primary outcome was any puncture-site wound event within 2 weeks after surgery, defined as erythema or swelling, bleeding or exudate, subcutaneous hematoma, or infection. Prespecified demographic, clinical, laboratory, and procedure-related candidate factors were first evaluated in univariable screening analyses. Modified Poisson regression with robust standard errors was then used to estimate adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for variables meeting the screening criterion or selected a priori for clinical relevance.

Results: Among 1,307 eligible patients, 136 (10.4%) had recorded early puncture-site wound events. Suture closure (RR: 2.24; 95% CI: 1.59–3.16; P < 0.001), diabetes (RR: 1.57; 95% CI: 1.11–2.21; P = 0.010), elevated international normalized ratio (RR: 1.66; 95% CI: 1.08–2.57; P = 0.022), and multilevel treatment (RR: 1.73; 95% CI: 1.03–2.89; P = 0.038) were associated with a higher adjusted risk of the composite outcome. Age, sex, and body mass index were not independently associated with the composite outcome in the primary model. In the crude comparison by closure method, any event occurred in 53 of 774 patients (6.8%) with nonsuture closure and in 83 of 533 patients (15.6%) with suture closure (crude RR: 2.27; 95% CI: 1.64–3.15; P < 0.001).

Conclusion: Early wound status after elective PVP for OVCFs was associated with metabolic and coagulation status, treatment extent, and local puncture-site closure method. These findings should be interpreted within the limits of a retrospective observational study.

Related

  1. Percutaneous Vertebroplasty for Painful Osteoporotic Vertebral Compression Fractures: A Retrospective Comparative Study of a Negative Pressure‐Guided Technique
    Botao Zhang, Zihan Wang, Shibing Zhang +7
    Orthopaedic SurgeryPeer-reviewedCC BY 4.0Full textSurgery & anaesthesiaPMC
  2. V-Shape Lumbar Bridge: postural reduction combined with percutaneous vertebroplasty for the treatment of osteoporotic compression fractures
    Yazhong Zhang, Ziqiang Zhu, Xuebin Tang +5
    BMC Musculoskeletal DisordersPeer-reviewedCC BY-NC-ND 4.0Full textSurgery & anaesthesiaPMC
  3. Effects of percutaneous kyphoplasty with concomitant postural reduction in the treatment of acute osteoporotic vertebral compression fractures
    Yulin Chen, Peng Yang, Ankejiang Anniwaer +4
    Frontiers in medicinePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Comparison of Two Puncture Approaches in Robot-Assisted Percutaneous Kyphoplasty for Upper Thoracic Osteoporotic Vertebral Compression Fractures.
    Yongtao Yang, Wei Chen, Rujie Qin +1
    Radiology research and practicePeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMC
  5. Asymptomatic Intracardiac Migration of a Cane-Shaped Polymethylmethacrylate Cement Embolus Following Percutaneous Vertebroplasty
    Jinchul Noh, Sanghoun Lee, Youngmin Oh +1
    Journal of medical casesPeer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{he2026factors,
  title = {{Factors associated with early puncture-site wound events after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a retrospective cohort study}},
  author = {Xiangle He and Changzhi Huang and Bingqian Zheng and Xianliang Wu and Chengguo Huang and Shuqiang Lu and Yufeng Huang and Jinghan Chen and Jianjun Huang and Bei Li},
  journal = {Frontiers in Medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1988843},
  url = {https://doi.org/10.3389/fmed.2026.1988843},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Factors associated with early puncture-site wound events after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a retrospective cohort study
AU  - Xiangle He
AU  - Changzhi Huang
AU  - Bingqian Zheng
AU  - Xianliang Wu
AU  - Chengguo Huang
AU  - Shuqiang Lu
AU  - Yufeng Huang
AU  - Jinghan Chen
AU  - Jianjun Huang
AU  - Bei Li
PY  - 2026
DA  - 2026/10/21
JO  - Frontiers in Medicine
DO  - 10.3389/fmed.2026.1988843
UR  - https://doi.org/10.3389/fmed.2026.1988843
AB  - Objective: Early puncture-site wound events after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) often receive less attention than major complications, but they may influence early wound monitoring and postoperative risk assessment. This study aimed to identify factors associated with early puncture-site wound events after elective PVP.  Methods: This single-center retrospective cohort study included consecutive patients who underwent elective PVP for OVCFs between January 2022 and June 2026. The primary outcome was any puncture-site wound event within 2 weeks after surgery, defined as erythema or swelling, bleeding or exudate, subcutaneous hematoma, or infection. Prespecified demographic, clinical, laboratory, and procedure-related candidate factors were first evaluated in univariable screening analyses. Modified Poisson regression with robust standard errors was then used to estimate adjusted risk ratios (RRs) and 95% confidence intervals (CIs) for variables meeting the screening criterion or selected a priori for clinical relevance.  Results: Among 1,307 eligible patients, 136 (10.4%) had recorded early puncture-site wound events. Suture closure (RR: 2.24; 95% CI: 1.59–3.16; P < 0.001), diabetes (RR: 1.57; 95% CI: 1.11–2.21; P = 0.010), elevated international normalized ratio (RR: 1.66; 95% CI: 1.08–2.57; P = 0.022), and multilevel treatment (RR: 1.73; 95% CI: 1.03–2.89; P = 0.038) were associated with a higher adjusted risk of the composite outcome. Age, sex, and body mass index were not independently associated with the composite outcome in the primary model. In the crude comparison by closure method, any event occurred in 53 of 774 patients (6.8%) with nonsuture closure and in 83 of 533 patients (15.6%) with suture closure (crude RR: 2.27; 95% CI: 1.64–3.15; P < 0.001).  Conclusion: Early wound status after elective PVP for OVCFs was associated with metabolic and coagulation status, treatment extent, and local puncture-site closure method. These findings should be interpreted within the limits of a retrospective observational study.
SN  - 2296-858X
ER  -