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Peer-reviewedCC BYFrontiers in pediatrics

Case Report: EAdi-guided ventilatory management leads to successful extubation in a pediatric myasthenic disorder.

  • Marjet J A M Braamskamp1
  • Alette A Koopman1
  • Martin C J Kneyber1,2
  1. 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, Netherlands.
  2. 2Critical Care, Anaesthesiology, Peri-Operative & Emergency Medicine (CAPE), University of Groningen, Groningen, Netherlands.
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Abstract

Monitoring of diaphragmatic electrical activity (EAdi) may provide real-time insight into neural respiratory drive, but data in pediatric myasthenic disease are scarce. We report a 2-year-old girl requiring mechanical ventilation for respiratory failure due to an initial diagnosis of myasthenic syndrome. Following initiation and escalation of pyridostigmine, median EAdi rose from 1.69 to 7.7 µV while ventilatory support was simultaneously reduced, resulting in successful extubation after 5 days. This case illustrates the potential added value of EAdi monitoring alongside conventional ventilator parameters in tracking neuromuscular recovery during weaning.

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Cite

BibTeXRIS
BibTeX
@article{braamskamp2026case,
  title = {{Case Report: EAdi-guided ventilatory management leads to successful extubation in a pediatric myasthenic disorder.}},
  author = {Marjet J A M Braamskamp and Alette A Koopman and Martin C J Kneyber},
  journal = {Frontiers in pediatrics},
  year = {2026},
  month = oct,
  doi = {10.3389/fped.2026.1893086},
  url = {https://europepmc.org/article/MED/42952742},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Case Report: EAdi-guided ventilatory management leads to successful extubation in a pediatric myasthenic disorder.
AU  - Marjet J A M Braamskamp
AU  - Alette A Koopman
AU  - Martin C J Kneyber
PY  - 2026
DA  - 2026/10/14
JO  - Frontiers in pediatrics
DO  - 10.3389/fped.2026.1893086
UR  - https://europepmc.org/article/MED/42952742
AB  - Monitoring of diaphragmatic electrical activity (EAdi) may provide real-time insight into neural respiratory drive, but data in pediatric myasthenic disease are scarce. We report a 2-year-old girl requiring mechanical ventilation for respiratory failure due to an initial diagnosis of myasthenic syndrome. Following initiation and escalation of pyridostigmine, median EAdi rose from 1.69 to 7.7 µV while ventilatory support was simultaneously reduced, resulting in successful extubation after 5 days. This case illustrates the potential added value of EAdi monitoring alongside conventional ventilator parameters in tracking neuromuscular recovery during weaning.
SN  - 2296-2360
ER  -