Skip to content
DraconiticResearch
Search Sources API
194,161 studies31 sourcesUpdated 43 min ago
Peer-reviewedCC BY 4.0Microbial Genomics

Whole-genome characterization of Candidozyma auris isolates from a Korean tertiary care centre: clade II predominance, partly unexplained fluconazole resistance and a clade I isolate

  • Jae Hyeon Park1
  • Jee-Soo Lee1,2
  • Seung Won Chae1,3
  • Taek Soo Kim1,2
  • Moon-Woo Seong1,2
  1. 1Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea
  2. 2Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
  3. 3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
Read full textDOICite

Abstract

In South Korea, Candidozyma auris is dominated by ear-associated clade II isolates, but institution-based genomic data remain limited. We analysed 35 archived isolates from 29 patients at a tertiary care centre between 2017 and 2023 using antifungal susceptibility testing and whole-genome sequencing. Thirty-four isolates belonged to clade II, and one urine isolate recovered after inter-hospital transfer belonged to subclade Ib. Serial clade II isolates from the same patient clustered together and had lower pairwise SNP distances than different-patient pairs (median, 8.5 versus 181). Among the first isolates from 29 patients, 14 (48.3%) were fluconazole resistant. In first clade II isolates, recurrent curated coding variation was concentrated in TAC1B and ERG11; TAC1B F214S and W198C and ERG11 K143R occurred only in resistant isolates, but recognized coding variants did not account for all resistant isolates. Clade II isolates shared a broadly conserved subtelomeric deletion backbone, with variable chromosome 6 loss of selected glycosylphosphatidylinositol-anchor genes. The clade Ib isolate carried ERG11 Y132F, TAC1B A583S and a CDR1 V704L/E709D-like change and met CDC tentative breakpoints for resistance to fluconazole, amphotericin B and caspofungin. These findings refine the genomic profile of Korean clade II isolates and highlight the potential introduction of a distinct clade I lineage through healthcare transfer.

Related

  1. Clinical correlates for fluconazole resistance in Candida bloodstream infections.
    Zihuan Li, Tian Wang, Mengdie Zhang +5
    Frontiers in public healthPeer-reviewedCC BYFull textInfectious diseaseEurope PMCCrossref
  2. SLA1 governs azole resistance in Candidozyma auris via mitochondrial ROS-driven efflux pump expression
    Chenhao Suo, Wanli Zhang, Yuhan Li +6
    Frontiers in MicrobiologyPeer-reviewedCC BY 4.0Full textInfectious diseaseCrossrefEurope PMC
  3. Predominance of SCCmec type III, multidrug resistance, and evidence of ica-independent biofilm formation among clinical Staphylococcus aureus isolates in Riyadh, Saudi Arabia
    Meshari Alabdullatif
    BMC Infectious DiseasesPeer-reviewedCC BYFull textInfectious diseaseDOAJ
  4. The catheterized urinary tract selects for MRR1-mediated efflux and fluconazole resistance in Candida albicans biofilms
    Shane A. Cristy, Jennifer N. Walker, Michael C. Lorenz
    mBioPeer-reviewedCC BY 4.0Full textInfectious diseasePMC
  5. Predominance of autoimmune heparin-induced thrombocytopenia in a nephrology department
    Manuel Laslandes, Claire Leman, Charles Ronsin +5
    Research and Practice in Thrombosis and HaemostasisPeer-reviewedCC BY-NC-ND 4.0Full textSurgery & anaesthesiaHAL

Cite

BibTeXRIS
BibTeX
@article{park2026wholegenome,
  title = {{Whole-genome characterization of Candidozyma auris isolates from a Korean tertiary care centre: clade II predominance, partly unexplained fluconazole resistance and a clade I isolate}},
  author = {Jae Hyeon Park and Jee-Soo Lee and Seung Won Chae and Taek Soo Kim and Moon-Woo Seong},
  journal = {Microbial Genomics},
  year = {2026},
  month = nov,
  doi = {10.1099/mgen.0.001802},
  url = {https://doi.org/10.1099/mgen.0.001802},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Whole-genome characterization of Candidozyma auris isolates from a Korean tertiary care centre: clade II predominance, partly unexplained fluconazole resistance and a clade I isolate
AU  - Jae Hyeon Park
AU  - Jee-Soo Lee
AU  - Seung Won Chae
AU  - Taek Soo Kim
AU  - Moon-Woo Seong
PY  - 2026
DA  - 2026/11/03
JO  - Microbial Genomics
DO  - 10.1099/mgen.0.001802
UR  - https://doi.org/10.1099/mgen.0.001802
AB  - In South Korea, Candidozyma auris is dominated by ear-associated clade II isolates, but institution-based genomic data remain limited. We analysed 35 archived isolates from 29 patients at a tertiary care centre between 2017 and 2023 using antifungal susceptibility testing and whole-genome sequencing. Thirty-four isolates belonged to clade II, and one urine isolate recovered after inter-hospital transfer belonged to subclade Ib. Serial clade II isolates from the same patient clustered together and had lower pairwise SNP distances than different-patient pairs (median, 8.5 versus 181). Among the first isolates from 29 patients, 14 (48.3%) were fluconazole resistant. In first clade II isolates, recurrent curated coding variation was concentrated in TAC1B and ERG11; TAC1B F214S and W198C and ERG11 K143R occurred only in resistant isolates, but recognized coding variants did not account for all resistant isolates. Clade II isolates shared a broadly conserved subtelomeric deletion backbone, with variable chromosome 6 loss of selected glycosylphosphatidylinositol-anchor genes. The clade Ib isolate carried ERG11 Y132F, TAC1B A583S and a CDR1 V704L/E709D-like change and met CDC tentative breakpoints for resistance to fluconazole, amphotericin B and caspofungin. These findings refine the genomic profile of Korean clade II isolates and highlight the potential introduction of a distinct clade I lineage through healthcare transfer.
SN  - 2057-5858
ER  -