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Peer-reviewedLicence not statedScience Translational Medicine

Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant

  • Susan DeWolf1
  • Steven J. Siegel2
  • Joseph Schmalz3
  • Wael Saber4
  • Alexandre Albanese5
  • Jiayi Dong5,6
  • Michael J. Martens7
  • Brent R. Logan8
  • Lorenzo Iovino9
  • Kayleigh Ingersoll Omdahl5
  • Nicholas Winn5
  • Edward Chen5
47 more authors
  • James J. Kaminski10,5
  • Donna S Neuberg11
  • Kyle M. Hebert11
  • Paula Keskula5
  • Jillian Zavistaski5
  • Lea Steinberg5
  • Isabella Schichter5
  • Zoe Katsamakis1
  • Lorenzo S Cagnin5
  • Vanessa A Hernandez12
  • Makya Warren12
  • Kristy Applegate13
  • Merav Bar9
  • Saurabh Chhabra14
  • Sung Won Choi15
  • William Clark16
  • Suman R. Das17
  • Robert R. Jenq18
  • Richard John Jones19
  • John E. Levine20
  • Hemant S. Murthy21
  • Armin Rashidi9
  • Marcie Riches22
  • Karamjeet Sandhu18
  • Anthony Derek Sung23
  • Karilyn T. M. Larkin24
  • Monzr M. Al Malki18
  • Mahasweta Gooptu25
  • Hany Elmariah26
  • Amin Majid Alousi27
  • Lyndsey Runaas28
  • Brian C. Shaffer29,30
  • Andrew R. Rezvani31
  • Najla El Jurdi32,33
  • Alison Wakoff Loren34
  • Danielle Scheffey3
  • Catherine Miller Sanders3
  • Mehdi Hamadani35
  • Jarrod A. Dudakov36
  • Stephanie A. Bien3
  • Harlan S. Robins3
  • Mary Horowitz35
  • Javier Bolaños‐Meade19
  • Shernan G. Holtan37
  • Ami Siddharth Bhatt38
  • Miguel‐Angel Perales29,30
  • Leslie S. Kean39
39 affiliations
  1. 1Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
  2. 2Department of Pediatrics, Harvard Medical School and Divisions of Infectious Diseases and Hematology/Oncology, Boston Children’s Hospital, Boston, MA, USA
  3. 3Adaptive Biotechnologies, Seattle, WA, USA
  4. 4Department of Medicine, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research (CIBMTR), Milwaukee, WI, USA
  5. 5Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA, USA
  6. 6Harvard Medical School, Boston, MA, USA
  7. 7CIBMTR and Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI, USA
  8. 8CIBMTR and Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, USA
  9. 9Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
  10. 10Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA
  11. 11Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA
  12. 12Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
  13. 13Emmes, Rockville, MD, USA
  14. 14Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ, USA
  15. 15Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
  16. 16Division of Hematology–Oncology and Palliative Care, Virginia Commonwealth University, Richmond, VA, USA
  17. 17Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
  18. 18Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA
  19. 19Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University and the Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  20. 20Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  21. 21Division of Hematology-Oncology and Blood and Marrow Transplant and Cellular Therapy Programs, Mayo Clinic, Jacksonville, FL, USA
  22. 22CIBMTR, Milwaukee, WI, USA
  23. 23Division of Hematologic Malignancies and Cellular Therapy, Kansas University Medical Center, Kansas City, KS, USA
  24. 24Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
  25. 25Department of Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  26. 26Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer and Research Institute, Tampa, FL, USA
  27. 27Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
  28. 28Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
  29. 29Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
  30. 30Department of Medicine, Weill Cornell Medical College, New York, NY, USA
  31. 31Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, CA, USA
  32. 32Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA
  33. 33Immune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
  34. 34Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
  35. 35Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
  36. 36Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center and Department of Immunology, University of Washington, Seattle, WA, USA
  37. 37Blood and Marrow Transplantation Section, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA
  38. 38Division of Hematology, Departments of Medicine and Genetics, Stanford University, Palo Alto, CA, USA
  39. 39Department of Pediatrics, Harvard Medical School, Division of Hematology/Oncology, Boston Children’s Hospital, and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{dewolf2026graftversushost,
  title = {{Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant}},
  author = {Susan DeWolf and Steven J. Siegel and Joseph Schmalz and Wael Saber and Alexandre Albanese and Jiayi Dong and Michael J. Martens and Brent R. Logan and Lorenzo Iovino and Kayleigh Ingersoll Omdahl and Nicholas Winn and Edward Chen and James J. Kaminski and Donna S Neuberg and Kyle M. Hebert and Paula Keskula and Jillian Zavistaski and Lea Steinberg and Isabella Schichter and Zoe Katsamakis and Lorenzo S Cagnin and Vanessa A Hernandez and Makya Warren and Kristy Applegate and Merav Bar and Saurabh Chhabra and Sung Won Choi and William Clark and Suman R. Das and Robert R. Jenq and Richard John Jones and John E. Levine and Hemant S. Murthy and Armin Rashidi and Marcie Riches and Karamjeet Sandhu and Anthony Derek Sung and Karilyn T. M. Larkin and Monzr M. Al Malki and Mahasweta Gooptu and Hany Elmariah and Amin Majid Alousi and Lyndsey Runaas and Brian C. Shaffer and Andrew R. Rezvani and Najla El Jurdi and Alison Wakoff Loren and Danielle Scheffey and Catherine Miller Sanders and Mehdi Hamadani and Jarrod A. Dudakov and Stephanie A. Bien and Harlan S. Robins and Mary Horowitz and Javier Bolaños‐Meade and Shernan G. Holtan and Ami Siddharth Bhatt and Miguel‐Angel Perales and Leslie S. Kean},
  journal = {Science Translational Medicine},
  year = {2026},
  month = oct,
  doi = {10.1126/scitranslmed.aef7406},
  url = {https://doi.org/10.1101/2025.02.25.25322901},
}
RIS
TY  - JOUR
TI  - Graft-versus-host disease prophylaxis shapes T cell biology and immune reconstitution after hematopoietic cell transplant
AU  - Susan DeWolf
AU  - Steven J. Siegel
AU  - Joseph Schmalz
AU  - Wael Saber
AU  - Alexandre Albanese
AU  - Jiayi Dong
AU  - Michael J. Martens
AU  - Brent R. Logan
AU  - Lorenzo Iovino
AU  - Kayleigh Ingersoll Omdahl
AU  - Nicholas Winn
AU  - Edward Chen
AU  - James J. Kaminski
AU  - Donna S Neuberg
AU  - Kyle M. Hebert
AU  - Paula Keskula
AU  - Jillian Zavistaski
AU  - Lea Steinberg
AU  - Isabella Schichter
AU  - Zoe Katsamakis
AU  - Lorenzo S Cagnin
AU  - Vanessa A Hernandez
AU  - Makya Warren
AU  - Kristy Applegate
AU  - Merav Bar
AU  - Saurabh Chhabra
AU  - Sung Won Choi
AU  - William Clark
AU  - Suman R. Das
AU  - Robert R. Jenq
AU  - Richard John Jones
AU  - John E. Levine
AU  - Hemant S. Murthy
AU  - Armin Rashidi
AU  - Marcie Riches
AU  - Karamjeet Sandhu
AU  - Anthony Derek Sung
AU  - Karilyn T. M. Larkin
AU  - Monzr M. Al Malki
AU  - Mahasweta Gooptu
AU  - Hany Elmariah
AU  - Amin Majid Alousi
AU  - Lyndsey Runaas
AU  - Brian C. Shaffer
AU  - Andrew R. Rezvani
AU  - Najla El Jurdi
AU  - Alison Wakoff Loren
AU  - Danielle Scheffey
AU  - Catherine Miller Sanders
AU  - Mehdi Hamadani
AU  - Jarrod A. Dudakov
AU  - Stephanie A. Bien
AU  - Harlan S. Robins
AU  - Mary Horowitz
AU  - Javier Bolaños‐Meade
AU  - Shernan G. Holtan
AU  - Ami Siddharth Bhatt
AU  - Miguel‐Angel Perales
AU  - Leslie S. Kean
PY  - 2026
DA  - 2026/10/21
JO  - Science Translational Medicine
DO  - 10.1126/scitranslmed.aef7406
UR  - https://doi.org/10.1101/2025.02.25.25322901
SN  - 1946-6234
SN  - 1946-6242
ER  -