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Peer-reviewedCC BYCase reports in dermatological medicine

Atrophic Dermatofibroma: A Rare Variant With Distinct Clinical and Histopathological Features.

  • Renad F Althobaiti1
  • Jana Khalid Alharbi2
  • Asmaa Alabbadi1
  • Dai Zafer3
  • Razan Alluhaibi2
  • Bayan Zakaria Hafiz4
4 affiliations
  1. 1College of Medicine Umm Al-Qura University Makkah Saudi Arabia uqu.edu.sa.
  2. 2Dermatology Department King Abdulaziz Hospital Makkah Saudi Arabia mngha.med.sa.
  3. 3Dermatology Department Makkah Health Cluster Makkah Saudi Arabia.
  4. 4Department of Pathology Makkah Health Cluster Makkah Saudi Arabia.
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Abstract

Dermatofibroma (DF) is a common benign cutaneous soft-tissue tumor that typically affects females between the third and fifth decades of life. While its pathogenesis is not fully understood, DF has been associated with minor local trauma and insect bites. We present a case of atrophic DF in a 35-year-old Saudi female who noticed a solitary, hyperpigmented, depressed plaque on her back that had been present for five years. The lesion initially appeared as a small papule but gradually increased in size while remaining asymptomatic, without pain, itching, or systemic complaints. Physical examination revealed a well-demarcated, hyperpigmented, depressed plaque without ulceration or surrounding erythema. Histopathological examination supported the diagnosis of atrophic DF, and immunohistochemical staining showed focal positivity for Factor XIIIa and negative staining for CD34, S100, HMB45, and p63. Atrophic DF is a rare variant characterized by a depressed clinical appearance and distinctive histopathological features that may create diagnostic challenges. Recognition of this uncommon presentation and correlation of the clinical, histopathological, and immunohistochemical findings can help distinguish it from other atrophic and spindle-cell cutaneous lesions.

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Cite

BibTeXRIS
BibTeX
@article{althobaiti2026atrophic,
  title = {{Atrophic Dermatofibroma: A Rare Variant With Distinct Clinical and Histopathological Features.}},
  author = {Renad F Althobaiti and Jana Khalid Alharbi and Asmaa Alabbadi and Dai Zafer and Razan Alluhaibi and Bayan Zakaria Hafiz},
  journal = {Case reports in dermatological medicine},
  year = {2026},
  month = oct,
  doi = {10.1155/crdm/4419249},
  url = {https://europepmc.org/article/MED/42909873},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Atrophic Dermatofibroma: A Rare Variant With Distinct Clinical and Histopathological Features.
AU  - Renad F Althobaiti
AU  - Jana Khalid Alharbi
AU  - Asmaa Alabbadi
AU  - Dai Zafer
AU  - Razan Alluhaibi
AU  - Bayan Zakaria Hafiz
PY  - 2026
DA  - 2026/10/21
JO  - Case reports in dermatological medicine
DO  - 10.1155/crdm/4419249
UR  - https://europepmc.org/article/MED/42909873
AB  - Dermatofibroma (DF) is a common benign cutaneous soft-tissue tumor that typically affects females between the third and fifth decades of life. While its pathogenesis is not fully understood, DF has been associated with minor local trauma and insect bites. We present a case of atrophic DF in a 35-year-old Saudi female who noticed a solitary, hyperpigmented, depressed plaque on her back that had been present for five years. The lesion initially appeared as a small papule but gradually increased in size while remaining asymptomatic, without pain, itching, or systemic complaints. Physical examination revealed a well-demarcated, hyperpigmented, depressed plaque without ulceration or surrounding erythema. Histopathological examination supported the diagnosis of atrophic DF, and immunohistochemical staining showed focal positivity for Factor XIIIa and negative staining for CD34, S100, HMB45, and p63. Atrophic DF is a rare variant characterized by a depressed clinical appearance and distinctive histopathological features that may create diagnostic challenges. Recognition of this uncommon presentation and correlation of the clinical, histopathological, and immunohistochemical findings can help distinguish it from other atrophic and spindle-cell cutaneous lesions.
SN  - 2090-6463
SN  - 2090-6471
ER  -