Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report

Abstract

Pulmonary hypertension (PH) is uncommon in myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) and its hemodynamics are poorly described. A 2-year-old Japanese girl was referred to our hospital with PH diagnosed during pneumonia treatment. Cardiac catheterization revealed PH with a high cardiac output. The patient was diagnosed with MELAS based on multiorgan involvement and the detection of an m.3243A>G mutation. PH therapy was partially effective, and oxygen supplementation may help improve PH without worsening the high cardiac output.

Comparison of Clinical, Hemodynamic and Imaging Profiles Between Isolated Pulmonary Vasculitis and Chronic Thromboembolic Pulmonary Hypertension
Xuesheng Fang, Hanwen Zhang, Yu Chen +15
Pulmonary circulation1 Oct 2026Peer-reviewedCC BY-NCFull textGeneral medicineEurope PMC
Physiology-Guided Management of Acute Right Ventricular Failure and Pulmonary Hypertension in Critically Ill Patients: Hemodynamic Phenotypes, Ventilator Interactions, and Rescue Strategies
Akram M. Eraky, Anita J. Chazhikattu, Joseph M. Crum +1
Medical sciences (Basel, Switzerland)1 Oct 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
4D-Flow MRI-Derived Wall Shear Stress as a Non-Invasive Biomarker for the Detection and Hemodynamic Characterization of Pulmonary Hypertension.
Ben Statton, Chlöe Armour, Kai'en Leong +7
Pulmonary circulation19 Oct 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
Association of Peak Circulatory Power with Invasive Hemodynamic Severity in Pulmonary Hypertension
Ya Song, Chao Shi, Yan-Li Gu +7
Journal of Clinical Medicine25 Oct 2026Peer-reviewedCC BY 4.0General medicineCrossref
Development and validation of novel prognostic hepatic-cardiac index and hemodynamic prediction models in pre-capillary pulmonary hypertension patients
Jun Tong, An Wang, Chuanxue Wan +6
Scientific Reports1 Jul 2026Peer-reviewedCC BYFull textGeneral medicineDOAJ

Cite

BibTeX RIS

BibTeX

@article{kanai2026pulmonary,
  title = {{Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report}},
  author = {Miki Kanai and Hirofumi Tsuru and Takanori Onuki and Shunsuke Nukaga and Shigehito Baba and Masanori Tsukada and Tadaaki Abe and Fujito Numano and Kei Murayama and Akihiko Saitoh},
  journal = {Internal Medicine},
  year = {2026},
  month = aug,
  doi = {10.2169/internalmedicine.7614-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Pulmonary Hypertension with a High-Output Hemodynamic Profile in a Child with MELAS: A Case Report
AU  - Miki Kanai
AU  - Hirofumi Tsuru
AU  - Takanori Onuki
AU  - Shunsuke Nukaga
AU  - Shigehito Baba
AU  - Masanori Tsukada
AU  - Tadaaki Abe
AU  - Fujito Numano
AU  - Kei Murayama
AU  - Akihiko Saitoh
PY  - 2026
DA  - 2026/08/08
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7614-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7614-26/_article
AB  - Pulmonary hypertension (PH) is uncommon in myopathy, encephalopathy, lactic acidosis, and stroke-like (MELAS) and its hemodynamics are poorly described. A 2-year-old Japanese girl was referred to our hospital with PH diagnosed during pneumonia treatment. Cardiac catheterization revealed PH with a high cardiac output. The patient was diagnosed with MELAS based on multiorgan involvement and the detection of an m.3243A>G mutation. PH therapy was partially effective, and oxygen supplementation may help improve PH without worsening the high cardiac output.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

Related

Cite