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Peer-reviewedCC BY-NC-NDThe journal of physiological sciences : JPS

Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats.

  • Saghi Hakimi Naeini1
  • Vahid Azizi1
  • Abdolkarim Hosseini2
  1. 1Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
  2. 2Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran. Electronic address: [email protected].
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Abstract

Objectives

Epilepsy is a neurological disorder characterized by recurrent seizures, posing significant challenges to patients' quality of life. Novel therapeutic agents are continuously sought to enhance seizure management. This study investigates the anticonvulsant potential of tolfenamic acid in a model of pentylenetetrazol (PTZ)-induced acute symptomatic seizures in male Wistar rats.Methods

Male Wistar rats were administered tolfenamic acid prior to PTZ-induced seizure induction. The anticonvulsant effects were evaluated by assessing seizure onset, severity, and duration. Biochemical assays were performed to measure oxidative stress and inflammatory markers.Results

Tolfenamic acid treatment significantly delayed the onset of seizures and reduced both seizure severity and duration compared to the negative control group (p < 0.05). Biochemical analysis revealed a notable modulation of oxidative stress and inflammatory pathways in rats treated with tolfenamic acid, indicating its neuroprotective properties (p < 0.05).Conclusions

The findings demonstrate the significant anticonvulsant and neuroprotective properties of tolfenamic acid in a PTZ-induced seizure model. By delaying seizure onset, reducing severity and duration, and modulating oxidative stress and inflammation, tolfenamic acid shows promise as a potential therapeutic agent for seizure management. Additional clinical trials are necessary to confirm these results in human populations and to investigate the potential of tolfenamic acid as a new treatment for epilepsy and related disorders.

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Cite

BibTeXRIS
BibTeX
@article{naeini2026anticonvulsant,
  title = {{Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats.}},
  author = {Saghi Hakimi Naeini and Vahid Azizi and Abdolkarim Hosseini},
  journal = {The journal of physiological sciences : JPS},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jphyss.2026.100109},
  url = {https://europepmc.org/article/MED/42892221},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Anticonvulsant potential of tolfenamic acid in pentylenetetrazol-induced acute symptomatic seizures in male wistar rats.
AU  - Saghi Hakimi Naeini
AU  - Vahid Azizi
AU  - Abdolkarim Hosseini
PY  - 2026
DA  - 2026/10/13
JO  - The journal of physiological sciences : JPS
DO  - 10.1016/j.jphyss.2026.100109
UR  - https://europepmc.org/article/MED/42892221
AB  - Objectives  Epilepsy is a neurological disorder characterized by recurrent seizures, posing significant challenges to patients' quality of life. Novel therapeutic agents are continuously sought to enhance seizure management. This study investigates the anticonvulsant potential of tolfenamic acid in a model of pentylenetetrazol (PTZ)-induced acute symptomatic seizures in male Wistar rats.Methods  Male Wistar rats were administered tolfenamic acid prior to PTZ-induced seizure induction. The anticonvulsant effects were evaluated by assessing seizure onset, severity, and duration. Biochemical assays were performed to measure oxidative stress and inflammatory markers.Results  Tolfenamic acid treatment significantly delayed the onset of seizures and reduced both seizure severity and duration compared to the negative control group (p < 0.05). Biochemical analysis revealed a notable modulation of oxidative stress and inflammatory pathways in rats treated with tolfenamic acid, indicating its neuroprotective properties (p < 0.05).Conclusions  The findings demonstrate the significant anticonvulsant and neuroprotective properties of tolfenamic acid in a PTZ-induced seizure model. By delaying seizure onset, reducing severity and duration, and modulating oxidative stress and inflammation, tolfenamic acid shows promise as a potential therapeutic agent for seizure management. Additional clinical trials are necessary to confirm these results in human populations and to investigate the potential of tolfenamic acid as a new treatment for epilepsy and related disorders.
SN  - 1880-6546
SN  - 1880-6562
ER  -