Peer-reviewedCC BYBJR case reports27 Oct 2026

[⁶⁸Ga]Ga-FAPI-46 PET/CT and [¹⁸F]FDG PET/CT in polymyalgia rheumatica, ovarian teratoma, and reactive peritoneal lesions: a case report.

Sofie L H Boye¹
Helle D Zacho^1,2
Camilla Sylvest³
Bence Gabor Szilvasy⁴
Morten Bentestuen^1,2

4 affiliations

¹Department of Nuclear Medicine and Clinical Cancer Research Center, Aalborg University Hospital, 9260 Gistrup, Denmark.
²Department of Clinical Medicine, Aalborg University, 9260 Gistrup, Denmark.
³Department of Gynecology and Obstetrics, Aalborg University Hospital, 9260 Gistrup, Denmark.
⁴Department of Pathology, Aalborg University Hospital, 9260 Gistrup, Denmark.

Abstract

In this case report, we present a 76-year-old woman who presented with an adnexal mass, ascites, and peritoneal lesions, all features highly suspicious for ovarian cancer (OC). The patient was enrolled in a clinical trial evaluating the diagnostic performance and clinical value of [68Ga]Ga-fibroblast activation protein inhibitor-46 ([68Ga]Ga-FAPI-46) PET/CT, a novel PET tracer that has demonstrated promising results in OC. The preoperative [18F]Fluorodeoxyglucose ([18F]FDG) PET/CT and [68Ga]Ga-FAPI-46 PET/CT showed up to moderate tracer uptake in the ovarian tumor and peritoneal lesions; however, final histopathology revealed a benign teratoma and peritoneal reactive changes. Furthermore, the patient had a history of polymyalgia rheumatica (PMR), and [18F]FDG PET/CT showed classic findings of PMR. [68Ga]Ga-FAPI-46 PET/CT revealed similar results, but with even higher tracer accumulation in affected locations. This case is the first to demonstrate the potential of [68Ga]Ga-FAPI-46 PET/CT in PMR.

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Cite

BibTeX RIS

BibTeX

@article{boye2026⁶⁸gagafapi46,
  title = {{[⁶⁸Ga]Ga-FAPI-46 PET/CT and [¹⁸F]FDG PET/CT in polymyalgia rheumatica, ovarian teratoma, and reactive peritoneal lesions: a case report.}},
  author = {Sofie L H Boye and Helle D Zacho and Camilla Sylvest and Bence Gabor Szilvasy and Morten Bentestuen},
  journal = {BJR case reports},
  year = {2026},
  month = oct,
  doi = {10.1093/bjrcr/uaag045},
  url = {https://europepmc.org/article/MED/42997964},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - [⁶⁸Ga]Ga-FAPI-46 PET/CT and [¹⁸F]FDG PET/CT in polymyalgia rheumatica, ovarian teratoma, and reactive peritoneal lesions: a case report.
AU  - Sofie L H Boye
AU  - Helle D Zacho
AU  - Camilla Sylvest
AU  - Bence Gabor Szilvasy
AU  - Morten Bentestuen
PY  - 2026
DA  - 2026/10/27
JO  - BJR case reports
DO  - 10.1093/bjrcr/uaag045
UR  - https://europepmc.org/article/MED/42997964
AB  - In this case report, we present a 76-year-old woman who presented with an adnexal mass, ascites, and peritoneal lesions, all features highly suspicious for ovarian cancer (OC). The patient was enrolled in a clinical trial evaluating the diagnostic performance and clinical value of [68Ga]Ga-fibroblast activation protein inhibitor-46 ([68Ga]Ga-FAPI-46) PET/CT, a novel PET tracer that has demonstrated promising results in OC. The preoperative [18F]Fluorodeoxyglucose ([18F]FDG) PET/CT and [68Ga]Ga-FAPI-46 PET/CT showed up to moderate tracer uptake in the ovarian tumor and peritoneal lesions; however, final histopathology revealed a benign teratoma and peritoneal reactive changes. Furthermore, the patient had a history of polymyalgia rheumatica (PMR), and [18F]FDG PET/CT showed classic findings of PMR. [68Ga]Ga-FAPI-46 PET/CT revealed similar results, but with even higher tracer accumulation in affected locations. This case is the first to demonstrate the potential of [68Ga]Ga-FAPI-46 PET/CT in PMR.
SN  - 2055-7159
ER  -

Abstract

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