Plasma Proteomic Profiles of Alzheimer's Disease and Neurodegeneration in African Cohorts
Abstract
Alzheimer's disease and related dementia (ADRD) represents a growing public health burden, especially in low- and middle-income countries. Yet, most studies focus on Non-Hispanic white (NHW) populations from high-income countries. This study investigates plasma proteomic signatures associated with amyloid pathology in African populations. Nigerian older adults from the VALIANT study and participants from a Tanzanian study, with available biomarker quantification in plasma are employed. For proteomic comparison, participants from the Canadian TRIAD cohort are included, capturing a distinct population. Here, we show that multiple proteins are differentially abundant in the plasma of p-tau217-positive individuals and in the different cognitive groups, with findings largely consistent amongst African cohorts. Comorbidities are significantly associated with protein levels and differences in plasma biomarkers levels are found between sexes. Lastly, VALIANT and TRIAD show both shared and unique protein profiles in relation to amyloid-pathology. These findings support the utility of fluid biomarkers in ADRD in African populations.
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BibTeX
@article{ashton2026plasma,
title = {{Plasma Proteomic Profiles of Alzheimer's Disease and Neurodegeneration in African Cohorts}},
author = {Nicholas J. Ashton and Rajesh Kalaria and Henrik Zetterberg and Pedro Rosa-Neto and Rufus O. Akinyemi and Andrea L. Benedet and Ilaria Pola and Tolulope Akinyemi and Kubra Tan and Oladotun Olalusi and Wiebke Traichel and Giulia Giacomucci and Joseph Yaria and Nesrine Rahmouni and Gabriel Ogunde and Olabode Oguntiloye and Arthur C. Macedo and Ayotomiwa Fagbemi and Eniola Cadmus and Joseph Therriault and Femi Popoola and Stella-Maria Paddick and Catherine Dotchin and Alyoce Kisoli and Richard Walker and Mayowa Ogunronbi and Dorcas Olujobi and Olaoluwa Famuyiwa and Joshua Akinyemi and Mayowa Owolabi and Chinedu T. Udeh-Momoh and Olusola Ladokun and Anthony Griswold and Roman Romero-Ortuno and Margaret Pericak-Vance and Adesola Ogunniyi and Stéphanie Debette and Brian Lawlor},
journal = {Nature Communications},
year = {2026},
month = sep,
doi = {10.1038/s41467-026-74971-4},
url = {https://hal.science/hal-05734018v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Plasma Proteomic Profiles of Alzheimer's Disease and Neurodegeneration in African Cohorts
AU - Nicholas J. Ashton
AU - Rajesh Kalaria
AU - Henrik Zetterberg
AU - Pedro Rosa-Neto
AU - Rufus O. Akinyemi
AU - Andrea L. Benedet
AU - Ilaria Pola
AU - Tolulope Akinyemi
AU - Kubra Tan
AU - Oladotun Olalusi
AU - Wiebke Traichel
AU - Giulia Giacomucci
AU - Joseph Yaria
AU - Nesrine Rahmouni
AU - Gabriel Ogunde
AU - Olabode Oguntiloye
AU - Arthur C. Macedo
AU - Ayotomiwa Fagbemi
AU - Eniola Cadmus
AU - Joseph Therriault
AU - Femi Popoola
AU - Stella-Maria Paddick
AU - Catherine Dotchin
AU - Alyoce Kisoli
AU - Richard Walker
AU - Mayowa Ogunronbi
AU - Dorcas Olujobi
AU - Olaoluwa Famuyiwa
AU - Joshua Akinyemi
AU - Mayowa Owolabi
AU - Chinedu T. Udeh-Momoh
AU - Olusola Ladokun
AU - Anthony Griswold
AU - Roman Romero-Ortuno
AU - Margaret Pericak-Vance
AU - Adesola Ogunniyi
AU - Stéphanie Debette
AU - Brian Lawlor
PY - 2026
DA - 2026/09/01
JO - Nature Communications
DO - 10.1038/s41467-026-74971-4
UR - https://hal.science/hal-05734018v1
AB - Alzheimer's disease and related dementia (ADRD) represents a growing public health burden, especially in low- and middle-income countries. Yet, most studies focus on Non-Hispanic white (NHW) populations from high-income countries. This study investigates plasma proteomic signatures associated with amyloid pathology in African populations. Nigerian older adults from the VALIANT study and participants from a Tanzanian study, with available biomarker quantification in plasma are employed. For proteomic comparison, participants from the Canadian TRIAD cohort are included, capturing a distinct population. Here, we show that multiple proteins are differentially abundant in the plasma of p-tau217-positive individuals and in the different cognitive groups, with findings largely consistent amongst African cohorts. Comorbidities are significantly associated with protein levels and differences in plasma biomarkers levels are found between sexes. Lastly, VALIANT and TRIAD show both shared and unique protein profiles in relation to amyloid-pathology. These findings support the utility of fluid biomarkers in ADRD in African populations.
SN - 2041-1723
SN - 2041-1723
ER -