Rapidly Progressive Diffuse Alveolar Damage Following Transbronchial Lung Biopsy in a Patient with Lung Adenocarcinoma: An Autopsy Case Report
Abstract
An 80-year-old man with a persistent cough underwent chest computed tomography, which revealed a pulmonary mass with subtle ground-glass opacities. A transbronchial lung biopsy confirmed lung adenocarcinoma. Shortly after bronchoscopy, the patient developed rapidly progressive hypoxemic respiratory failure, consistent with acute respiratory distress syndrome. Despite treatment with antibiotics and systemic corticosteroids, the patient died. The autopsy revealed adenocarcinoma with lymphangitic carcinomatosis and diffuse alveolar damage throughout both lungs, the latter being considered the immediate cause of death. This case indicates that diffuse alveolar damage-associated acute respiratory distress syndrome may occur even in treatment-naïve lung cancer patients.
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BibTeX
@article{idehata2026rapidly,
title = {{Rapidly Progressive Diffuse Alveolar Damage Following Transbronchial Lung Biopsy in a Patient with Lung Adenocarcinoma: An Autopsy Case Report}},
author = {Hiromi Idehata and Yu Nakanishi and Aoi Kurihara and Sora Mishima and Takahiro Kanbara and Takashi Saito and Shoshi Akieda and Masako Watanabe and Ryohei Nishino and Soichi Kitaguchi and Mayumi Kaneko and Fumihiro Sugahara},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.7536-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7536-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Rapidly Progressive Diffuse Alveolar Damage Following Transbronchial Lung Biopsy in a Patient with Lung Adenocarcinoma: An Autopsy Case Report
AU - Hiromi Idehata
AU - Yu Nakanishi
AU - Aoi Kurihara
AU - Sora Mishima
AU - Takahiro Kanbara
AU - Takashi Saito
AU - Shoshi Akieda
AU - Masako Watanabe
AU - Ryohei Nishino
AU - Soichi Kitaguchi
AU - Mayumi Kaneko
AU - Fumihiro Sugahara
PY - 2026
DA - 2026/08/01
JO - Internal Medicine
DO - 10.2169/internalmedicine.7536-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7536-26/_article
AB - An 80-year-old man with a persistent cough underwent chest computed tomography, which revealed a pulmonary mass with subtle ground-glass opacities. A transbronchial lung biopsy confirmed lung adenocarcinoma. Shortly after bronchoscopy, the patient developed rapidly progressive hypoxemic respiratory failure, consistent with acute respiratory distress syndrome. Despite treatment with antibiotics and systemic corticosteroids, the patient died. The autopsy revealed adenocarcinoma with lymphangitic carcinomatosis and diffuse alveolar damage throughout both lungs, the latter being considered the immediate cause of death. This case indicates that diffuse alveolar damage-associated acute respiratory distress syndrome may occur even in treatment-naïve lung cancer patients.
SN - 1349-7235
SN - 0918-2918
ER -