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Peer-reviewedCC BYJournal of cellular and molecular medicine

The Cytokine Response of Circulating Immune Cells to Rhinovirus (RV-A16) is Reduced in Severe Asthma.

  • Kaschin Jamal Jameel1
  • Sarah D Yanik1
  • Kai Robin Pfeifer1
  • Daniel Weidinger1
  • Simon Rohde1
  • Birte Struck1
  • Eike Bülthoff1
  • Paul Bürger1
  • Juliane Kronsbein1
  • Matthias Tenbusch2,3
  • Jürgen Knobloch1
  1. 1Medical Clinic III for Pneumology, Allergology, and Sleep Medicine, Bergmannsheil University Hospital, Ruhr University Bochum, Bochum, Germany.
  2. 2Harald Zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
  3. 3FAU Profile Center Immunomedicine (FAU I-MED), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.
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Abstract

Severe asthma patients (SA) are more susceptible to respiratory infections with human rhinoviruses (HRV) than healthy subjects (H), causing exacerbations. In response to HRV, circulating immune cells are recruited to and activated at the local sites of infection. Hypothesis: The activation of circulating immune cells in response to HRV is impaired in severe asthma. We infected peripheral blood mononuclear cells (PBMC) of H (n = 20) and SA (n = 50) with RV-A16 ex vivo. Cytokines were measured in culture supernatants by ELISA. Data were compared between SA and H and correlated to asthma phenotype biomarkers. RV-A16 induced IFNα, IFNγ, CCL2, CCL5, TNFα, IL-1β, IL-6 and IL-8. Except for CCL2, these cytokine responses were reduced in SA versus H. In SA, IFNα, IL-6 and CCL5 responses correlated negatively, but IL-1β correlated positively to FeNO. IFNγ correlated positively to blood eosinophils and serum IL-33, and INFα correlated positively to serum total IgE. Cytokine responses of circulating immune cells to RV-A16 are reduced in SA. Cytokines are differentially affected in allergic, eosinophilic or T2 low asthma. This could help to explain the increased risk for exacerbations in HRV infections in severe asthma and differences between phenotypes. Circulating immune cells might be considered as drug targets to reduce exacerbation rates.

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Cite

BibTeXRIS
BibTeX
@article{jameel2026cytokine,
  title = {{The Cytokine Response of Circulating Immune Cells to Rhinovirus (RV-A16) is Reduced in Severe Asthma.}},
  author = {Kaschin Jamal Jameel and Sarah D Yanik and Kai Robin Pfeifer and Daniel Weidinger and Simon Rohde and Birte Struck and Eike Bülthoff and Paul Bürger and Juliane Kronsbein and Matthias Tenbusch and Jürgen Knobloch},
  journal = {Journal of cellular and molecular medicine},
  year = {2026},
  month = nov,
  doi = {10.1111/jcmm.71410},
  url = {https://europepmc.org/article/MED/42968511},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The Cytokine Response of Circulating Immune Cells to Rhinovirus (RV-A16) is Reduced in Severe Asthma.
AU  - Kaschin Jamal Jameel
AU  - Sarah D Yanik
AU  - Kai Robin Pfeifer
AU  - Daniel Weidinger
AU  - Simon Rohde
AU  - Birte Struck
AU  - Eike Bülthoff
AU  - Paul Bürger
AU  - Juliane Kronsbein
AU  - Matthias Tenbusch
AU  - Jürgen Knobloch
PY  - 2026
DA  - 2026/11/01
JO  - Journal of cellular and molecular medicine
DO  - 10.1111/jcmm.71410
UR  - https://europepmc.org/article/MED/42968511
AB  - Severe asthma patients (SA) are more susceptible to respiratory infections with human rhinoviruses (HRV) than healthy subjects (H), causing exacerbations. In response to HRV, circulating immune cells are recruited to and activated at the local sites of infection. Hypothesis: The activation of circulating immune cells in response to HRV is impaired in severe asthma. We infected peripheral blood mononuclear cells (PBMC) of H (n = 20) and SA (n = 50) with RV-A16 ex vivo. Cytokines were measured in culture supernatants by ELISA. Data were compared between SA and H and correlated to asthma phenotype biomarkers. RV-A16 induced IFNα, IFNγ, CCL2, CCL5, TNFα, IL-1β, IL-6 and IL-8. Except for CCL2, these cytokine responses were reduced in SA versus H. In SA, IFNα, IL-6 and CCL5 responses correlated negatively, but IL-1β correlated positively to FeNO. IFNγ correlated positively to blood eosinophils and serum IL-33, and INFα correlated positively to serum total IgE. Cytokine responses of circulating immune cells to RV-A16 are reduced in SA. Cytokines are differentially affected in allergic, eosinophilic or T2 low asthma. This could help to explain the increased risk for exacerbations in HRV infections in severe asthma and differences between phenotypes. Circulating immune cells might be considered as drug targets to reduce exacerbation rates.
SN  - 1582-1838
SN  - 1582-4934
ER  -