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Peer-reviewedCC BY 4.0Molecules

Chemical Composition and Acetylcholinesterase Inhibitory Activity of the Volatile Fraction from the Ecuadorian Moss Sphagnum magellanicum Brid

  • James Calva1
  • Juan Francisco Dávila2
  • Eduardo Valarezo1
  • Ángel Benítez3
  1. 1Departamento de Química, Universidad Técnica Particular de Loja, Loja 110107, Ecuador
  2. 2Carrera de Ingeniería Química, Universidad Técnica Particular de Loja, Loja 110107, Ecuador
  3. 3Biodiversidad de Ecosistemas Tropicales-BIETROP, Herbario HUTPL, Departamento de Ciencias Biológicas y Agropecuarias, Universidad Técnica Particular de Loja (UTPL), Calle Paris s/n y Praga, Loja 110107, Ecuador
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Abstract

The volatile fraction (VF) of the aerial parts of Sphagnum magellanicum Brid. (Sphagnaceae), collected in southern Ecuador (2740 m a.s.l), was obtained for the first time by steam distillation using a Dean–Stark adapted apparatus and characterized by gas chromatography coupled to mass spectrometry (GC-MS) and flame ionization detection (GC-FID). A total of 89 compounds representing 95.28 ± 1.95% of the total VF were identified. The predominant chemical classes were n-alkanes (39.94%), alcohols (17.56%), sesquiterpene hydrocarbons (13.10%), and oxygenated sesquiterpenes (6.48%). Phytol was the major single compound (16.09 ± 0.07%), followed by n-tricosane (9.25 ± 0.82%), n-heneicosane (9.17 ± 0.54%), hexacosane (7.30 ± 0.99%), nonacosane (5.42 ± 0.14%), (Z)-caryophyllene (4.08 ± 0.32%), hexadecanoic acid (3.64 ± 0.25%), and dotriacontane (2.93 ± 0.21%). The VF was evaluated in vitro for acetylcholinesterase (AChE) inhibitory activity using the Ellman colorimetric assay, yielding a moderate inhibitory effect with an IC50 value of 77.0 ± 1.03 µg/mL. These results provide the first phytochemical and pharmacological characterization of S. magellanicum from Ecuador, establishing it as a potential source of bioactive volatile constituents with potential relevance for further pharmacological investigation.

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Cite

BibTeXRIS
BibTeX
@article{calva2026chemical,
  title = {{Chemical Composition and Acetylcholinesterase Inhibitory Activity of the Volatile Fraction from the Ecuadorian Moss Sphagnum magellanicum Brid}},
  author = {James Calva and Juan Francisco Dávila and Eduardo Valarezo and Ángel Benítez},
  journal = {Molecules},
  year = {2026},
  month = oct,
  doi = {10.3390/molecules31213797},
  url = {https://www.mdpi.com/1420-3049/31/21/3797},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Chemical Composition and Acetylcholinesterase Inhibitory Activity of the Volatile Fraction from the Ecuadorian Moss Sphagnum magellanicum Brid
AU  - James Calva
AU  - Juan Francisco Dávila
AU  - Eduardo Valarezo
AU  - Ángel Benítez
PY  - 2026
DA  - 2026/10/22
JO  - Molecules
DO  - 10.3390/molecules31213797
UR  - https://www.mdpi.com/1420-3049/31/21/3797
AB  - The volatile fraction (VF) of the aerial parts of Sphagnum magellanicum Brid. (Sphagnaceae), collected in southern Ecuador (2740 m a.s.l), was obtained for the first time by steam distillation using a Dean–Stark adapted apparatus and characterized by gas chromatography coupled to mass spectrometry (GC-MS) and flame ionization detection (GC-FID). A total of 89 compounds representing 95.28 ± 1.95% of the total VF were identified. The predominant chemical classes were n-alkanes (39.94%), alcohols (17.56%), sesquiterpene hydrocarbons (13.10%), and oxygenated sesquiterpenes (6.48%). Phytol was the major single compound (16.09 ± 0.07%), followed by n-tricosane (9.25 ± 0.82%), n-heneicosane (9.17 ± 0.54%), hexacosane (7.30 ± 0.99%), nonacosane (5.42 ± 0.14%), (Z)-caryophyllene (4.08 ± 0.32%), hexadecanoic acid (3.64 ± 0.25%), and dotriacontane (2.93 ± 0.21%). The VF was evaluated in vitro for acetylcholinesterase (AChE) inhibitory activity using the Ellman colorimetric assay, yielding a moderate inhibitory effect with an IC50 value of 77.0 ± 1.03 µg/mL. These results provide the first phytochemical and pharmacological characterization of S. magellanicum from Ecuador, establishing it as a potential source of bioactive volatile constituents with potential relevance for further pharmacological investigation.
SN  - 1420-3049
ER  -