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Peer-reviewedCC BYJournal of ophthalmic & vision research

Effect of Eye Movement and Body Position on Optic Nerve Sheath Width.

  • Duy Huyhn1
  • Simran Ohri1
  • Viraj Garg2
  • Jason Zehden2
  • Jessica Duddleston2
  • Christopher Wiesen3
  • Maja Kostic2
  • David Fleischman2
  1. 1Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
  2. 2Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina, USA.
  3. 3Odum Institute for Research in Social Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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Abstract

Purpose

Orbital cerebrospinal fluid (CSF) dynamics are poorly understood but are postulated to play a role in several optic nerve pathologies. This study aims to evaluate the effects of eye movement and body position on perioptic CSF clearance by optic nerve sheath width (ONSW) measurement.Methods

Healthy adult patients were recruited prospectively from an outpatient ophthalmology clinic at an academic center. B-mode ultrasound was used to measure optic nerve sheath width (ONSW) 3 mm posterior to the optic disc after 5 minutes of no eye movement (-EM) and 1 minute of eye movement (+EM) in three body positions: upright, supine, and prone. CSF clearance is the difference between ONSW +EM and -EM in each body position.Results

Thirty-eight adults with healthy optic nerves were recruited. ONSW -EM were significantly wider than +EM in all three positions (P = 0.002, 0.024, 0.002). Body positioning only significantly affected ONSW -EM (P = 0.030), while +EM ONSW was not significantly different in any body position, indicating a baseline effect.Conclusion

Eye movement and body position significantly impact orbital CSF dynamics and ONSW. Prone positioning increased ONSW, highlighting the role of gravity dependence in perioptic CSF clearance. Identifying factors that impact CSF dynamics is imperative to understanding its part in optic nerve disease.

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Cite

BibTeXRIS
BibTeX
@article{huyhn2026effect,
  title = {{Effect of Eye Movement and Body Position on Optic Nerve Sheath Width.}},
  author = {Duy Huyhn and Simran Ohri and Viraj Garg and Jason Zehden and Jessica Duddleston and Christopher Wiesen and Maja Kostic and David Fleischman},
  journal = {Journal of ophthalmic \& vision research},
  year = {2026},
  month = oct,
  doi = {10.18502/jovr.v21.17638},
  url = {https://europepmc.org/article/MED/43011643},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Effect of Eye Movement and Body Position on Optic Nerve Sheath Width.
AU  - Duy Huyhn
AU  - Simran Ohri
AU  - Viraj Garg
AU  - Jason Zehden
AU  - Jessica Duddleston
AU  - Christopher Wiesen
AU  - Maja Kostic
AU  - David Fleischman
PY  - 2026
DA  - 2026/10/22
JO  - Journal of ophthalmic & vision research
DO  - 10.18502/jovr.v21.17638
UR  - https://europepmc.org/article/MED/43011643
AB  - Purpose  Orbital cerebrospinal fluid (CSF) dynamics are poorly understood but are postulated to play a role in several optic nerve pathologies. This study aims to evaluate the effects of eye movement and body position on perioptic CSF clearance by optic nerve sheath width (ONSW) measurement.Methods  Healthy adult patients were recruited prospectively from an outpatient ophthalmology clinic at an academic center. B-mode ultrasound was used to measure optic nerve sheath width (ONSW) 3 mm posterior to the optic disc after 5 minutes of no eye movement (-EM) and 1 minute of eye movement (+EM) in three body positions: upright, supine, and prone. CSF clearance is the difference between ONSW +EM and -EM in each body position.Results  Thirty-eight adults with healthy optic nerves were recruited. ONSW -EM were significantly wider than +EM in all three positions (P = 0.002, 0.024, 0.002). Body positioning only significantly affected ONSW -EM (P = 0.030), while +EM ONSW was not significantly different in any body position, indicating a baseline effect.Conclusion  Eye movement and body position significantly impact orbital CSF dynamics and ONSW. Prone positioning increased ONSW, highlighting the role of gravity dependence in perioptic CSF clearance. Identifying factors that impact CSF dynamics is imperative to understanding its part in optic nerve disease.
SN  - 2008-2010
SN  - 2008-322X
ER  -