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PreprintCC BYChemRxiv

Interaction effects and droplet dynamics in chitosan-coated nanoemulsions via echo-Diffusing Wave Spectroscopy

  • Logan-Marie Torry1,2
  • Foluso Akin-Ige1,2
  • Jose Huergo3,2
  • Amy Yang4,2
  • Leah Knight1,2
  • Samiul Amin1,2
4 affiliations
  1. 1Engineering, College of Engineering
  2. 2University of Miami
  3. 3Department of Physics, College of Arts and Sciences
  4. 4Department of Chemistry, College of Arts and Sciences
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Abstract

In this work, interaction effects and droplet dynamics in chitosan-coated nanoemulsions were investigated via echo-Diffusing Wave Spectroscopy (DWS). Medium-chain triglyceride (MCT) nanoemulsions containing 5–10% (w/w) oil were prepared with and without chitosan. Experimental photon transport mean free paths, were compared with non-interacting, hard-sphere, and excluded-annulus scattering models to evaluate the contribution of inter-droplet correlations. Intensity correlation functions were analyzed against scaled delay time, to account for differences in photon transport, while mean squared displacements (MSDs) were used to characterize inferred droplet motion. Chitosan incorporation produced non-monotonic changes in photon transport and correlation relaxation, while generally reducing the apparent droplet displacement. The excluded-annulus model provided a useful first approximation of selected intermediate-concentration formulations but was not able to capture the full concentration dependence, highlighting the limitations of representing the hydrated chitosan layer as a fixed exclusion boundary. The findings reveal a concentration-dependent interplay between longer-range interactions governing inter-droplet organization and hydrodynamic coupling and shorter-range interactions involving the hydrated polymer layer. This study demonstrates the value of echo-DWS for investigating interaction effects in polymer-coated nanoemulsions and provides a physical framework for their rational design as drug-delivery carriers.

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Cite

BibTeXRIS
BibTeX
@misc{torry2026interaction,
  title = {{Interaction effects and droplet dynamics in chitosan-coated nanoemulsions via echo-Diffusing Wave Spectroscopy}},
  author = {Logan-Marie Torry and Foluso Akin-Ige and Jose Huergo and Amy Yang and Leah Knight and Samiul Amin},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15009966/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009966/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Interaction effects and droplet dynamics in chitosan-coated nanoemulsions via echo-Diffusing Wave Spectroscopy
AU  - Logan-Marie Torry
AU  - Foluso Akin-Ige
AU  - Jose Huergo
AU  - Amy Yang
AU  - Leah Knight
AU  - Samiul Amin
PY  - 2026
DA  - 2026/10/06
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009966/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009966/v1
AB  - In this work, interaction effects and droplet dynamics in chitosan-coated nanoemulsions were investigated via echo-Diffusing Wave Spectroscopy (DWS). Medium-chain triglyceride (MCT) nanoemulsions containing 5–10% (w/w) oil were prepared with and without chitosan. Experimental photon transport mean free paths, were compared with non-interacting, hard-sphere, and excluded-annulus scattering models to evaluate the contribution of inter-droplet correlations. Intensity correlation functions were analyzed against scaled delay time, to account for differences in photon transport, while mean squared displacements (MSDs) were used to characterize inferred droplet motion. Chitosan incorporation produced non-monotonic changes in photon transport and correlation relaxation, while generally reducing the apparent droplet displacement. The excluded-annulus model provided a useful first approximation of selected intermediate-concentration formulations but was not able to capture the full concentration dependence, highlighting the limitations of representing the hydrated chitosan layer as a fixed exclusion boundary. The findings reveal a concentration-dependent interplay between longer-range interactions governing inter-droplet organization and hydrodynamic coupling and shorter-range interactions involving the hydrated polymer layer. This study demonstrates the value of echo-DWS for investigating interaction effects in polymer-coated nanoemulsions and provides a physical framework for their rational design as drug-delivery carriers.
ER  -