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Peer-reviewedCC BYEnvironmental science & technology

Maternal Epigenetic Signatures Linking Prenatal Serum PFAS Concentrations to Birth Size in an African American Maternal-Child Cohort.

  • Youran Tan1
  • Anne L Dunlop2
  • Todd M Everson1
  • Alicia K Smith2
  • Stephanie M Eick1
  • Ziyin Tang1
  • Shudi Pan1
  • Neha Sehgal1
  • Dana Boyd Barr1
  • Kurunthachalam Kannan3
  • P Barry Ryan1
  • Carmen J Marsit1
1 more authors
  • Donghai Liang1
  1. 1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia30322, United States.
  2. 2Department of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, Georgia30322, United States.
  3. 3Wadsworth Center, New York State Department of Health, Albany, New York12237, United States.
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Abstract

Per- and polyfluoroalkyl substance (PFAS) exposures have been linked to reduced birth size, but the underlying epigenetic mechanisms remain unclear. Among 296 mother-infant dyads in the Atlanta African American Maternal-Child Cohort (2016-2020), early pregnancy maternal blood samples (8-14 weeks) were processed for serum PFAS assessment and blood mononuclear cell (PBMC) DNA methylation profiling. We assessed birth size using sex-specific birth weight z-scores (BWZ) and small-for-gestational-age (SGA) status. Individual and mixture PFAS methylation associations were estimated by using robust generalized linear regression and quantile g-computation. We also conducted differentially methylated region (DMR), gene ontology, sex-specific, and exploratory mediation analyses. Overall, 132 CpGs were associated with at least one PFAS (FDR < 0.05), including 34, 60, 32, and 10 linked with PFHxS, PFOS, PFOA, and PFNA, respectively. PFOS showed the largest effects and appeared to drive the mixture associations. Six CpGs (annotated to EVA1A, FCRL1, CTIF, ABHD12, and WDYHV1) were associated with PFAS levels and birth size indicators. We identified 2-9 DMRs associated with individual PFASs and their mixture. Sex-specific PFAS methylation associations were observed. The PFAS-associated genes are involved in the inflammatory response, immune activity, and lipid homeostasis. Prenatal serum PFAS concentrations were associated with alterations in maternal DNA methylation, which in turn were associated with infant birth size.

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Cite

BibTeXRIS
BibTeX
@article{tan2026maternal,
  title = {{Maternal Epigenetic Signatures Linking Prenatal Serum PFAS Concentrations to Birth Size in an African American Maternal-Child Cohort.}},
  author = {Youran Tan and Anne L Dunlop and Todd M Everson and Alicia K Smith and Stephanie M Eick and Ziyin Tang and Shudi Pan and Neha Sehgal and Dana Boyd Barr and Kurunthachalam Kannan and P Barry Ryan and Carmen J Marsit and Donghai Liang},
  journal = {Environmental science \& technology},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.est.6c03113},
  url = {https://europepmc.org/article/MED/42917010},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Maternal Epigenetic Signatures Linking Prenatal Serum PFAS Concentrations to Birth Size in an African American Maternal-Child Cohort.
AU  - Youran Tan
AU  - Anne L Dunlop
AU  - Todd M Everson
AU  - Alicia K Smith
AU  - Stephanie M Eick
AU  - Ziyin Tang
AU  - Shudi Pan
AU  - Neha Sehgal
AU  - Dana Boyd Barr
AU  - Kurunthachalam Kannan
AU  - P Barry Ryan
AU  - Carmen J Marsit
AU  - Donghai Liang
PY  - 2026
DA  - 2026/10/01
JO  - Environmental science & technology
DO  - 10.1021/acs.est.6c03113
UR  - https://europepmc.org/article/MED/42917010
AB  - Per- and polyfluoroalkyl substance (PFAS) exposures have been linked to reduced birth size, but the underlying epigenetic mechanisms remain unclear. Among 296 mother-infant dyads in the Atlanta African American Maternal-Child Cohort (2016-2020), early pregnancy maternal blood samples (8-14 weeks) were processed for serum PFAS assessment and blood mononuclear cell (PBMC) DNA methylation profiling. We assessed birth size using sex-specific birth weight z-scores (BWZ) and small-for-gestational-age (SGA) status. Individual and mixture PFAS methylation associations were estimated by using robust generalized linear regression and quantile g-computation. We also conducted differentially methylated region (DMR), gene ontology, sex-specific, and exploratory mediation analyses. Overall, 132 CpGs were associated with at least one PFAS (FDR < 0.05), including 34, 60, 32, and 10 linked with PFHxS, PFOS, PFOA, and PFNA, respectively. PFOS showed the largest effects and appeared to drive the mixture associations. Six CpGs (annotated to EVA1A, FCRL1, CTIF, ABHD12, and WDYHV1) were associated with PFAS levels and birth size indicators. We identified 2-9 DMRs associated with individual PFASs and their mixture. Sex-specific PFAS methylation associations were observed. The PFAS-associated genes are involved in the inflammatory response, immune activity, and lipid homeostasis. Prenatal serum PFAS concentrations were associated with alterations in maternal DNA methylation, which in turn were associated with infant birth size.
SN  - 0013-936X
SN  - 1520-5851
ER  -