Low Body Weight and Long-Term Outcomes in Cancer-Associated Venous Thromboembolism ― From the COMMAND VTE Registry-2 ―
Abstract
BACKGROUND: Low body weight (BW) is reportedly associated with an increased risk of bleeding and mortality in venous thromboembolism (VTE). However, there are limited data on the impact of low BW on clinical outcomes among patients with cancer-associated VTE in the direct oral anticoagulants (DOACs) era. METHODS AND RESULTS: We analyzed 1,484 patients with symptomatic VTE and active cancer from the COMMAND VTE Registry-2, and divided the cohort into low (≤60 kg) and non-low (>60 kg) BW groups (n=969 and 515, respectively). The cumulative 3-year incidence of major bleeding was significantly higher in the low than non-low BW group (13.1% vs. 10.2%; Gray's P=0.04). However, after adjustment, the risk of major bleeding in the low BW was no longer significantly different to that in the non-low BW group (hazard ratio [HR] 1.36; 95% confidence interval [CI] 0.96-1.92). The cumulative 3-year incidence of recurrent VTE did not differ significantly between the low and non-low groups (5.2% vs. 5.4%, respectively; Gray's P=0.46; adjusted HR 0.71; 95% CI 0.42-1.18). The cumulative 3-year incidence of all-cause death was significantly higher in the low than non-low BW group (65.0% vs. 50.8%; log-rank P<0.001; adjusted HR 1.47; 95% CI 1.25-1.73). CONCLUSIONS: Low BW in cancer-associated VTE was not associated with major bleeding or recurrent VTE, but was associated with all-cause death, possibly reflecting cancer-related prognostic factors.
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BibTeX
@article{kobayashi2026body,
title = {{Low Body Weight and Long-Term Outcomes in Cancer-Associated Venous Thromboembolism ― From the COMMAND VTE Registry-2 ―}},
author = {Soichiro Kobayashi and Yoshito Ogihara and Yugo Yamashita and Takeshi Morimoto and Ryuki Chatani and Kazuhisa Kaneda and Yuji Nishimoto and Nobutaka Ikeda and Yohei Kobayashi and Satoshi Ikeda and Kitae Kim and Masayuki Shiba and Toru Takase and Shuhei Tsuji and Maki Oi and Takuma Takada and Kazunori Otsui and Jiro Sakamoto and Takeshi Inoue and Shunsuke Usami and Po-Min Chen and Kiyonori Togi and Norimichi Koitabashi and Seiichi Hiramori and Kosuke Doi and Hiroshi Mabuchi and Yoshiaki Tsuyuki and Koichiro Murata and Kensuke Takabayashi and Hisato Nakai and Daisuke Sueta and Wataru Shioyama and Tomohiro Dohke and Toru Sato and Ryusuke Nishikawa and Takeshi Kimura and Kaoru Dohi and on behalf of the COMMAND VTE Registry-2 Investigators},
journal = {Circulation Journal},
year = {2026},
month = sep,
doi = {10.1253/circj.cj-26-0325},
url = {https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-26-0325/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Low Body Weight and Long-Term Outcomes in Cancer-Associated Venous Thromboembolism ― From the COMMAND VTE Registry-2 ―
AU - Soichiro Kobayashi
AU - Yoshito Ogihara
AU - Yugo Yamashita
AU - Takeshi Morimoto
AU - Ryuki Chatani
AU - Kazuhisa Kaneda
AU - Yuji Nishimoto
AU - Nobutaka Ikeda
AU - Yohei Kobayashi
AU - Satoshi Ikeda
AU - Kitae Kim
AU - Masayuki Shiba
AU - Toru Takase
AU - Shuhei Tsuji
AU - Maki Oi
AU - Takuma Takada
AU - Kazunori Otsui
AU - Jiro Sakamoto
AU - Takeshi Inoue
AU - Shunsuke Usami
AU - Po-Min Chen
AU - Kiyonori Togi
AU - Norimichi Koitabashi
AU - Seiichi Hiramori
AU - Kosuke Doi
AU - Hiroshi Mabuchi
AU - Yoshiaki Tsuyuki
AU - Koichiro Murata
AU - Kensuke Takabayashi
AU - Hisato Nakai
AU - Daisuke Sueta
AU - Wataru Shioyama
AU - Tomohiro Dohke
AU - Toru Sato
AU - Ryusuke Nishikawa
AU - Takeshi Kimura
AU - Kaoru Dohi
AU - on behalf of the COMMAND VTE Registry-2 Investigators
PY - 2026
DA - 2026/09/25
JO - Circulation Journal
DO - 10.1253/circj.cj-26-0325
UR - https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-26-0325/_article
AB - BACKGROUND: Low body weight (BW) is reportedly associated with an increased risk of bleeding and mortality in venous thromboembolism (VTE). However, there are limited data on the impact of low BW on clinical outcomes among patients with cancer-associated VTE in the direct oral anticoagulants (DOACs) era. METHODS AND RESULTS: We analyzed 1,484 patients with symptomatic VTE and active cancer from the COMMAND VTE Registry-2, and divided the cohort into low (≤60 kg) and non-low (>60 kg) BW groups (n=969 and 515, respectively). The cumulative 3-year incidence of major bleeding was significantly higher in the low than non-low BW group (13.1% vs. 10.2%; Gray's P=0.04). However, after adjustment, the risk of major bleeding in the low BW was no longer significantly different to that in the non-low BW group (hazard ratio [HR] 1.36; 95% confidence interval [CI] 0.96-1.92). The cumulative 3-year incidence of recurrent VTE did not differ significantly between the low and non-low groups (5.2% vs. 5.4%, respectively; Gray's P=0.46; adjusted HR 0.71; 95% CI 0.42-1.18). The cumulative 3-year incidence of all-cause death was significantly higher in the low than non-low BW group (65.0% vs. 50.8%; log-rank P<0.001; adjusted HR 1.47; 95% CI 1.25-1.73). CONCLUSIONS: Low BW in cancer-associated VTE was not associated with major bleeding or recurrent VTE, but was associated with all-cause death, possibly reflecting cancer-related prognostic factors.
SN - 1347-4820
SN - 1346-9843
ER -