Prognosis of 1st time revision due to pain following primary total hip arthroplasty - a nationwide cohort study from the Danish Hip Arthroplasty Register
- 1Department of Orthopedic Surgery and Traumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen.
Abstract
Revision total hip arthroplasty (THA) for persistent or unexplained pain remains controversial. Uncertainty remains regarding the subsequent risk of re-revision following revision THA for pain.
The objectives of this study are to compare the risk of all-cause and cause-specific re-revision following first-time revision THA performed for pain versus aseptic loosening.
This nationwide, register-based cohort study will use data from the Danish Hip Arthroplasty Register. Patients who underwent primary THA followed by first-time revision THA for pain or aseptic loosening between 1995 and 2025 will be included. Patients will be followed from the index revision until re-revision, death, emigration, or end of follow-up. The primary outcome is time to all-cause re-revision. Secondary outcomes are cause-specific re-revision due to pain, aseptic loosening, infection, or dislocation. Cumulative incidence will be estimated using competing-risk methods, and hazard ratios will be estimated using Cox proportional hazards regression.
The study will provide nationwide evidence on the risk of re-revision following revision THA for pain and may inform clinical decision-making and patient counselling.
Related
- Association between cemented and uncemented cups and risk of revision in patients aged 65 years or older following primary total hip arthroplasty: a study of 310,515 patients from the Nordic Arthroplasty Register Association.
- Comparing Short-Term Clinical Outcomes and Survivorship of Complex Revision Total Hip Arthroplasty: Custom Triflange Acetabular Implants Vs Standard Cage Reconstruction
- Early Revision Rates and Clinical Outcomes of Two Cementless Cruciate-Retaining Total Knee Arthroplasty Designs at Two-Year Follow-Up: A Propensity Score-Adjusted Comparative Analysis
- Use of a high-speed pencil-tip burr for removal of well-fixed humeral components in revision shoulder arthroplasty
- Plasma albumin and the risk of amputation and mortality in patients hospitalised with diabetic foot ulcers: a Danish nationwide register-based cohort study
BibTeX
@misc{hald2026prognosis,
title = {{Prognosis of 1st time revision due to pain following primary total hip arthroplasty - a nationwide cohort study from the Danish Hip Arthroplasty Register}},
author = {P. P. Hald and S. M. Aljuboori and S. Overgaard},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.09.26361766},
url = {https://www.medrxiv.org/content/10.64898/2026.09.09.26361766v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Prognosis of 1st time revision due to pain following primary total hip arthroplasty - a nationwide cohort study from the Danish Hip Arthroplasty Register
AU - P. P. Hald
AU - S. M. Aljuboori
AU - S. Overgaard
PY - 2026
DA - 2026/09/09
PB - medRxiv
DO - 10.64898/2026.09.09.26361766
UR - https://www.medrxiv.org/content/10.64898/2026.09.09.26361766v1
AB - Revision total hip arthroplasty (THA) for persistent or unexplained pain remains controversial. Uncertainty remains regarding the subsequent risk of re-revision following revision THA for pain. The objectives of this study are to compare the risk of all-cause and cause-specific re-revision following first-time revision THA performed for pain versus aseptic loosening. This nationwide, register-based cohort study will use data from the Danish Hip Arthroplasty Register. Patients who underwent primary THA followed by first-time revision THA for pain or aseptic loosening between 1995 and 2025 will be included. Patients will be followed from the index revision until re-revision, death, emigration, or end of follow-up. The primary outcome is time to all-cause re-revision. Secondary outcomes are cause-specific re-revision due to pain, aseptic loosening, infection, or dislocation. Cumulative incidence will be estimated using competing-risk methods, and hazard ratios will be estimated using Cox proportional hazards regression. The study will provide nationwide evidence on the risk of re-revision following revision THA for pain and may inform clinical decision-making and patient counselling.
ER -