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Peer-reviewedCC BY-NC-NDJournal of materials science. Materials in medicine

Efficacy and safety of a novel glaucoma drainage tube with a porous outer structure (GDTI-50H) in rabbit eyes.

  • Wanting Wu1,2,3
  • Suping Yu4
  • Nanjin Li1,2,3
  • Shan Liang5
  • Jinchuan Zhao5
  • Xiaoyu Wang6
  • Junhua Li7,8
8 affiliations
  1. 1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
  2. 2State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
  3. 3Wenzhou Medical University, Wenzhou, China.
  4. 4Hangzhou Hiyouth+ Hospital, Hangzhou, China.
  5. 5EastPoint Innovation Center Co. Ltd, Hangzhou, China.
  6. 6Tianchen Runmu (Suzhou) Biotechnology Co. Ltd, Suzhou, China. [email protected].
  7. 7National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. [email protected].
  8. 8State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China. [email protected].
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Abstract

We developed a novel glaucoma drainage tube, designated as GDTI-50H. The outer opening end of the drainage tube is provided with multiple drainage holes, which allows for normal drainage of aqueous humor through the remaining holes when one of the drainage holes becomes blocked. It is potentially enhancing the sustained drainage efficiency. Fourteen New Zealand white rabbits were randomly assigned to receive GDTI-50H implantation in either the right or left eye as the test eye, with the contralateral eye serving as its own control (undergoing sham surgery). Intraocular pressure(IOP) was continuously monitored within 12 weeks postoperatively, combined with slit-lamp microscopy, anterior segment optical coherence tomography (OCT) imaging, Trypan Blue patency test, and histopathological examination. Results showed that IOP in the test group was significantly lower than that in the control group at 12 weeks postoperatively (all differences were statistically significant, p < 0.05). Anterior segment OCT showed that drainage tube was accurately positioned within the anterior chamber angle without displacement or detachment. The Trypan Blue patency test demonstrated that at 12 weeks postoperatively, Trypan Blue dye could still drain from the anterior chamber into the subconjunctival space in the test group. Hematoxylin and Eosin staining images showed no significant inflammatory cell infiltration around drainage tube. This study demonstrated that after implantation of drainage tube into the anterior chamber of rabbit eyes, and it has certain efficacy and safety in controlling IOP.

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Cite

BibTeXRIS
BibTeX
@article{wu2026efficacy,
  title = {{Efficacy and safety of a novel glaucoma drainage tube with a porous outer structure (GDTI-50H) in rabbit eyes.}},
  author = {Wanting Wu and Suping Yu and Nanjin Li and Shan Liang and Jinchuan Zhao and Xiaoyu Wang and Junhua Li},
  journal = {Journal of materials science. Materials in medicine},
  year = {2026},
  month = jul,
  doi = {10.1007/s10856-026-07108-0},
  url = {https://europepmc.org/article/MED/42902079},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Efficacy and safety of a novel glaucoma drainage tube with a porous outer structure (GDTI-50H) in rabbit eyes.
AU  - Wanting Wu
AU  - Suping Yu
AU  - Nanjin Li
AU  - Shan Liang
AU  - Jinchuan Zhao
AU  - Xiaoyu Wang
AU  - Junhua Li
PY  - 2026
DA  - 2026/07/01
JO  - Journal of materials science. Materials in medicine
DO  - 10.1007/s10856-026-07108-0
UR  - https://europepmc.org/article/MED/42902079
AB  - We developed a novel glaucoma drainage tube, designated as GDTI-50H. The outer opening end of the drainage tube is provided with multiple drainage holes, which allows for normal drainage of aqueous humor through the remaining holes when one of the drainage holes becomes blocked. It is potentially enhancing the sustained drainage efficiency. Fourteen New Zealand white rabbits were randomly assigned to receive GDTI-50H implantation in either the right or left eye as the test eye, with the contralateral eye serving as its own control (undergoing sham surgery). Intraocular pressure(IOP) was continuously monitored within 12 weeks postoperatively, combined with slit-lamp microscopy, anterior segment optical coherence tomography (OCT) imaging, Trypan Blue patency test, and histopathological examination. Results showed that IOP in the test group was significantly lower than that in the control group at 12 weeks postoperatively (all differences were statistically significant, p < 0.05). Anterior segment OCT showed that drainage tube was accurately positioned within the anterior chamber angle without displacement or detachment. The Trypan Blue patency test demonstrated that at 12 weeks postoperatively, Trypan Blue dye could still drain from the anterior chamber into the subconjunctival space in the test group. Hematoxylin and Eosin staining images showed no significant inflammatory cell infiltration around drainage tube. This study demonstrated that after implantation of drainage tube into the anterior chamber of rabbit eyes, and it has certain efficacy and safety in controlling IOP.
SN  - 0957-4530
SN  - 1573-4838
ER  -