Effect of delayed remote ischemic preconditioning on major cardiovascular and cerebrovascular events in major vascular surgery: the protocol of DRIPC randomized controlled trial
- 1Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University
- 2West China School of Medicine, Sichuan University
- 3Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University
Abstract
Introduction: Although endovascular therapy has become the mainstream approach for major vascular surgery, patients undergoing such procedures are still classified as high-risk according to clinical guidelines. Remote ischemic preconditioning (RIPC) is a promising perioperative intervention strategy that has demonstrated acceptable safety and efficacy. Existing research indicates that delayed remote ischemic preconditioning (DRIPC) offers superior protective effects compared to preconditioning performed within 24 h before surgery. However, there is currently a lack of Level I evidence regarding the efficacy and safety of DRIPC in the perioperative period for vascular surgery patients. This study aims to provide high-level evidence on the effectiveness and safety of this intervention in a clinical setting.
Methods and analysis: The trial is a single-center, prospective, double-blind, randomized controlled clinical trial. A total of 1,054 patients will be recruited. The primary endpoints of the study include major adverse cardiac and cerebrovascular events (MACCE) within 30 days postoperatively.
Ethics and dissemination: This study has been approved by the Ethics Committee of West China Hospital of Sichuan University (approval number:2025-1846). The results will be submitted to a major clinical journal for peer review and publication.
Clinical Trial registration: identifier ChiCTR2600116987
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BibTeX
@article{zhu2026effect,
title = {{Effect of delayed remote ischemic preconditioning on major cardiovascular and cerebrovascular events in major vascular surgery: the protocol of DRIPC randomized controlled trial}},
author = {Linyao Zhu and Min Li and Jichun Zhao and Bin Huang and Ding Yuan and Chengxin Weng and Tiehao Wang and Huawei Zhang and Jiarong Wang},
journal = {Frontiers in Cardiovascular Medicine},
year = {2026},
month = oct,
doi = {10.3389/fcvm.2026.1952010},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1952010/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Effect of delayed remote ischemic preconditioning on major cardiovascular and cerebrovascular events in major vascular surgery: the protocol of DRIPC randomized controlled trial
AU - Linyao Zhu
AU - Min Li
AU - Jichun Zhao
AU - Bin Huang
AU - Ding Yuan
AU - Chengxin Weng
AU - Tiehao Wang
AU - Huawei Zhang
AU - Jiarong Wang
PY - 2026
DA - 2026/10/08
JO - Frontiers in Cardiovascular Medicine
DO - 10.3389/fcvm.2026.1952010
UR - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1952010/full
AB - Introduction: Although endovascular therapy has become the mainstream approach for major vascular surgery, patients undergoing such procedures are still classified as high-risk according to clinical guidelines. Remote ischemic preconditioning (RIPC) is a promising perioperative intervention strategy that has demonstrated acceptable safety and efficacy. Existing research indicates that delayed remote ischemic preconditioning (DRIPC) offers superior protective effects compared to preconditioning performed within 24 h before surgery. However, there is currently a lack of Level I evidence regarding the efficacy and safety of DRIPC in the perioperative period for vascular surgery patients. This study aims to provide high-level evidence on the effectiveness and safety of this intervention in a clinical setting. Methods and analysis: The trial is a single-center, prospective, double-blind, randomized controlled clinical trial. A total of 1,054 patients will be recruited. The primary endpoints of the study include major adverse cardiac and cerebrovascular events (MACCE) within 30 days postoperatively. Ethics and dissemination: This study has been approved by the Ethics Committee of West China Hospital of Sichuan University (approval number:2025-1846). The results will be submitted to a major clinical journal for peer review and publication. Clinical Trial registration: identifier ChiCTR2600116987
SN - 2297-055X
ER -