Skip to content
DraconiticResearch
Search Sources API
201,818 studies31 sourcesUpdated 29 min ago
Peer-reviewedCC BYMicroorganisms

The Gut–Vagina Axis

  • Lorenzo Agoni1
  • Elena Roselletti2
  • Giovanni Marasco3
  • Canio Vito Martinelli4,5
  • Eva Pericolini6
  • Francesco De Seta7
7 affiliations
  1. 1Unit of Obstetrics and Gynecology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
  2. 2Department of Biosciences, Faculty of Health and Life Sciences, Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK
  3. 3Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
  4. 4Sbarro Institute for Cancer Research and Molecular Medicine and Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
  5. 5Unit of Obstetrics and Gynecology, Department of Human Pathology of Adult and Childhood “Gaetano Barresi”, University of Messina, 98124 Messina, Italy
  6. 6Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41124 Modena, Italy
  7. 7Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
Open at sourcePDFDOICite

Abstract

The gut-vagina axis has emerged as a growing area of interest in female health due to its potential role in mediating physiological processes via interactions between distinct microbiomes, including microbial migration, hormonal and immune regulation, and metabolite exchange. Recent advances in microbiome research suggest bidirectional communication between gut and vaginal communities, with potential effects on microbial composition, immune responses, hormonal balance, and metabolic activity in both sites. In this review, we outline the most promising features of the gut-vaginal relationship, emphasize the significance of their plausible bidirectional communication, and discuss how these interactions may affect local and systemic health.

Related

  1. The Klf7/Glut2/Ins2 Axis Regulates Glucose Homeostasis
    International journal of molecular sciencesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC
  2. Modulating the NLRP3/IL-1β Axis in Age-Related Atherosclerosis: Natural Products, Molecular Mechanisms, and Translational Perspectives—A Narrative Review
    BiomoleculesPeer-reviewedCC BYFull textGeneral biochemistryEurope PMC
  3. A Shift in the Plasma 7-Oxysterol Redox Axis in Colorectal Cancer
    Muhammad Kamran, Irundika H. K. Dias, Akinfemi Akingboye +1
    MetabolitesPeer-reviewedCC BYFull textProteomics & metabolomicsEurope PMC
  4. Editorial: Decoding the gut-brain axis: implications for neurodegenerative disease therapies
    R. M. Damian Holsinger, R. M. Damian Holsinger
    Frontiers in Aging NeurosciencePeer-reviewedCC BYFull textMolecular biology & gene regulationDOAJ
  5. From Exosomal Cargo to In Vivo Causality: Interpreting the miR-146a-5p/SMAD4 Axis After Glaucoma Filtration Surgery
    Peiwen Chen
    Investigative Ophthalmology & Visual SciencePeer-reviewedCC BY-NC-ND 4.0Full textMolecular biology & gene regulationPMC

Cite

BibTeXRIS
BibTeX
@article{agoni2026gutvagina,
  title = {{The Gut–Vagina Axis}},
  author = {Lorenzo Agoni and Elena Roselletti and Giovanni Marasco and Canio Vito Martinelli and Eva Pericolini and Francesco De Seta},
  journal = {Microorganisms},
  year = {2026},
  month = jun,
  doi = {10.3390/microorganisms14061327},
  url = {https://doi.org/10.3390/microorganisms14061327},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The Gut–Vagina Axis
AU  - Lorenzo Agoni
AU  - Elena Roselletti
AU  - Giovanni Marasco
AU  - Canio Vito Martinelli
AU  - Eva Pericolini
AU  - Francesco De Seta
PY  - 2026
DA  - 2026/06/13
JO  - Microorganisms
DO  - 10.3390/microorganisms14061327
UR  - https://doi.org/10.3390/microorganisms14061327
AB  - The gut-vagina axis has emerged as a growing area of interest in female health due to its potential role in mediating physiological processes via interactions between distinct microbiomes, including microbial migration, hormonal and immune regulation, and metabolite exchange. Recent advances in microbiome research suggest bidirectional communication between gut and vaginal communities, with potential effects on microbial composition, immune responses, hormonal balance, and metabolic activity in both sites. In this review, we outline the most promising features of the gut-vaginal relationship, emphasize the significance of their plausible bidirectional communication, and discuss how these interactions may affect local and systemic health.
SN  - 2076-2607
ER  -