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Peer-reviewedCC BYPLOS Biology

Alzheimer’s disease research must connect vascular molecular phenotypes with physiology

  • Thomas S Lewis1,2
  • Jessica Wagner1,2
  • Jonas J Neher1,2,3,4
4 affiliations
  1. 1Biomedical Center, Metabolic Biochemistry, LMU Medizin, LMU Munich, Munich, Germany.
  2. 2Neuroimmunology and Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  3. 3Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
  4. 4Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
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Abstract

Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion.

Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. This Perspective argues for longitudinal studies to link molecular and structural changes to vascular mechanics, hemodynamics and tissue perfusion.

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Cite

BibTeXRIS
BibTeX
@article{lewis2026alzheimers,
  title = {{Alzheimer’s disease research must connect vascular molecular phenotypes with physiology}},
  author = {Thomas S Lewis and Jessica Wagner and Jonas J Neher},
  journal = {PLOS Biology},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pbio.3004051},
  url = {https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004051},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Alzheimer’s disease research must connect vascular molecular phenotypes with physiology
AU  - Thomas S Lewis
AU  - Jessica Wagner
AU  - Jonas J Neher
PY  - 2026
DA  - 2026/10/28
JO  - PLOS Biology
DO  - 10.1371/journal.pbio.3004051
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3004051
AB  - Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion.  Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. This Perspective argues for longitudinal studies to link molecular and structural changes to vascular mechanics, hemodynamics and tissue perfusion.
SN  - 1545-7885
SN  - 1544-9173
ER  -