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Peer-reviewedCC BY-NC 4.0Clinical Pediatrics

Modified Diabetic Ketoacidosis Treatment Protocol: Safe, Simple, and Easy to Apply

  • Deniz Özalp Kızılay1
  • Özge Yıldırım Şalbaş2
  • Ece Derin Aydın3
  • Hasan Selçuk Özkan4
  • Günay Demir1
  • Korcan Demir2
  • Samim Özen1
  • Şükran Darcan1
  • Damla Gökşen1
4 affiliations
  1. 1Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, Ege University Faculty of Medicine, Izmir, Turkey
  2. 2Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey
  3. 3Department of Paediatrics, Ege University Faculty of Medicine, Izmir, Turkey
  4. 4Ege University Faculty of Medicine, Izmir, Turkey
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Abstract

The optimal intravenous fluid (IVF) administration rate in the treatment of pediatric diabetic ketoacidosis (DKA) is controversial. Our aim is to investigate the efficacy of a modified fixed IVF calculation in pediatric DKA. All patients received rehydration fluid at a standard rate of 3000 mL/m²/24 h. The infusion rate remained constant and was not changed for dehydration severity, age, baseline blood glucose level, daily fluid deficit, or maintenance fluid requirement calculation.

Data from 252 patients diagnosed with DKA were recorded. Of them, 126 were treated with the modified IVF procedure and 126 with the International Society for Paediatric and Adolescent Diabetes IVF regimen. Acidosis recovery time was 9 (2-46) and 9 (2-34) hours, respectively (P = .48). Treatment groups showed no statistically significant differences in treatment-related problems. The modified IVF protocol can be safely and efficiently utilized in the pediatric population, excluding those requiring initial intensive care unit management, without the need to calculate daily fluid deficit or maintenance fluid need.

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Cite

BibTeXRIS
BibTeX
@article{kızılay2026modified,
  title = {{Modified Diabetic Ketoacidosis Treatment Protocol: Safe, Simple, and Easy to Apply}},
  author = {Deniz Özalp Kızılay and Özge Yıldırım Şalbaş and Ece Derin Aydın and Hasan Selçuk Özkan and Günay Demir and Korcan Demir and Samim Özen and Şükran Darcan and Damla Gökşen},
  journal = {Clinical Pediatrics},
  year = {2026},
  month = aug,
  doi = {10.1177/00099228261455064},
  url = {https://doi.org/10.1177/00099228261455064},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Modified Diabetic Ketoacidosis Treatment Protocol: Safe, Simple, and Easy to Apply
AU  - Deniz Özalp Kızılay
AU  - Özge Yıldırım Şalbaş
AU  - Ece Derin Aydın
AU  - Hasan Selçuk Özkan
AU  - Günay Demir
AU  - Korcan Demir
AU  - Samim Özen
AU  - Şükran Darcan
AU  - Damla Gökşen
PY  - 2026
DA  - 2026/08/18
JO  - Clinical Pediatrics
DO  - 10.1177/00099228261455064
UR  - https://doi.org/10.1177/00099228261455064
AB  - The optimal intravenous fluid (IVF) administration rate in the treatment of pediatric diabetic ketoacidosis (DKA) is controversial. Our aim is to investigate the efficacy of a modified fixed IVF calculation in pediatric DKA. All patients received rehydration fluid at a standard rate of 3000 mL/m²/24 h. The infusion rate remained constant and was not changed for dehydration severity, age, baseline blood glucose level, daily fluid deficit, or maintenance fluid requirement calculation.  Data from 252 patients diagnosed with DKA were recorded. Of them, 126 were treated with the modified IVF procedure and 126 with the International Society for Paediatric and Adolescent Diabetes IVF regimen. Acidosis recovery time was 9 (2-46) and 9 (2-34) hours, respectively (P = .48). Treatment groups showed no statistically significant differences in treatment-related problems. The modified IVF protocol can be safely and efficiently utilized in the pediatric population, excluding those requiring initial intensive care unit management, without the need to calculate daily fluid deficit or maintenance fluid need.
SN  - 0009-9228
SN  - 1938-2707
ER  -