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Peer-reviewedCC BYAdvances in pharmacological and pharmaceutical sciences

Medicinal Compositions of Long Stephania Herb Exhibit Antilung Cancer Effects.

  • Xiaobing Chen1
  • Luying Zhang1
  • Wanying Zhang1
  • Xueqin Wu1
  • Kun Liu1
  • Yuli Zhou1
  • Yongqing Chen2
  • Mingyue Zhu1
  • Bo Lin1
  • Mengsen Li1,3
  1. 1Key Laboratory of Tropical Translational Medicine Ministry of Education, and Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical University Haikou 571199 Hainan China hainmc.edu.cn.
  2. 2Department of Respiratory and Critical Care Medicine Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical University Haikou 570311 Hainan China hyfyuan.com.
  3. 3Department of Medical Oncology Second Affiliated Hospital Hainan Medical University Haikou 570216 Hainan China hainmc.edu.cn.
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Abstract

Lung cancer is one of the most common malignancies worldwide, and due to its high mortality rate and resistance to treatment, there is an urgent need to develop effective treatments with low toxicity. Long stephania herb (LSH) is a tropical herb used clinically for the treatment of inflammation and analgesia, but its antitumor effects are unknown. In this study, UHPLC-OE-MS was used to detect the chemical components of LSH; the cytotoxic effects of these chemical components on normal lung cells and non-small cell lung cancer (NSCLC) cell lines were observed in vitro cell experiments, and the inhibitory effects of LSH on the growth of NSCLC were detected in animal tumor models. The possible molecular targets of LSH for NSCLC were predicted by network pharmacology and molecular docking. The results showed that LSH has more than a thousand chemical components; at the microgram level per milliliter, it can effectively inhibit the proliferation, migration, and invasion of lung cancer A549 cells and promote apoptosis in these cells. It also can effectively inhibit the growth of tumors in vivo and has no significant toxic effects on normal lungs, liver, heart, and kidneys. Analysis showed that 20 pharmacodynamic components of LSH may target EGFR, PIK3CA, PIK3R1, AKT1, HSP90AA1, SRC, MAPK1, MAPK3, STAT3, JUN, and CASP3. Inhibition of the PI3K/AKT signaling pathway and proteoglycans in cancer and other signaling pathways plays an anti-NSCLC role. In conclusion, this study is the first to report the efficacy of LSH in the treatment of NSCLC, and it is a very valuable tropical medicinal plant for the treatment of lung cancer.

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Cite

BibTeXRIS
BibTeX
@article{chen2026medicinal,
  title = {{Medicinal Compositions of Long Stephania Herb Exhibit Antilung Cancer Effects.}},
  author = {Xiaobing Chen and Luying Zhang and Wanying Zhang and Xueqin Wu and Kun Liu and Yuli Zhou and Yongqing Chen and Mingyue Zhu and Bo Lin and Mengsen Li},
  journal = {Advances in pharmacological and pharmaceutical sciences},
  year = {2026},
  month = oct,
  doi = {10.1155/adpp/8058846},
  url = {https://europepmc.org/article/MED/42959582},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Medicinal Compositions of Long Stephania Herb Exhibit Antilung Cancer Effects.
AU  - Xiaobing Chen
AU  - Luying Zhang
AU  - Wanying Zhang
AU  - Xueqin Wu
AU  - Kun Liu
AU  - Yuli Zhou
AU  - Yongqing Chen
AU  - Mingyue Zhu
AU  - Bo Lin
AU  - Mengsen Li
PY  - 2026
DA  - 2026/10/28
JO  - Advances in pharmacological and pharmaceutical sciences
DO  - 10.1155/adpp/8058846
UR  - https://europepmc.org/article/MED/42959582
AB  - Lung cancer is one of the most common malignancies worldwide, and due to its high mortality rate and resistance to treatment, there is an urgent need to develop effective treatments with low toxicity. Long stephania herb (LSH) is a tropical herb used clinically for the treatment of inflammation and analgesia, but its antitumor effects are unknown. In this study, UHPLC-OE-MS was used to detect the chemical components of LSH; the cytotoxic effects of these chemical components on normal lung cells and non-small cell lung cancer (NSCLC) cell lines were observed in vitro cell experiments, and the inhibitory effects of LSH on the growth of NSCLC were detected in animal tumor models. The possible molecular targets of LSH for NSCLC were predicted by network pharmacology and molecular docking. The results showed that LSH has more than a thousand chemical components; at the microgram level per milliliter, it can effectively inhibit the proliferation, migration, and invasion of lung cancer A549 cells and promote apoptosis in these cells. It also can effectively inhibit the growth of tumors in vivo and has no significant toxic effects on normal lungs, liver, heart, and kidneys. Analysis showed that 20 pharmacodynamic components of LSH may target EGFR, PIK3CA, PIK3R1, AKT1, HSP90AA1, SRC, MAPK1, MAPK3, STAT3, JUN, and CASP3. Inhibition of the PI3K/AKT signaling pathway and proteoglycans in cancer and other signaling pathways plays an anti-NSCLC role. In conclusion, this study is the first to report the efficacy of LSH in the treatment of NSCLC, and it is a very valuable tropical medicinal plant for the treatment of lung cancer.
SN  - 2633-4682
SN  - 2633-4690
ER  -