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Peer-reviewedCC BY-NC-NDEuropean journal of case reports in internal medicine

Identical Critical Left Anterior Descending Artery Stenosis in Monozygotic Twins.

  • Aya Cohen1
  • Dan Justo1,2
  • Israel Barabash2,3
  • Keren Zisman4,5
  • Asaf Danon4,5
5 affiliations
  1. 1Geriatrics Division, Sheba Medical Center, Ramat-Gan, Israel.
  2. 2Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Israel.
  3. 3Cardiology Division, Sheba Medical Center, Ramat-Gan, Israel.
  4. 4Cardiology Division, Lady Davis Carmel Medical Center, Haifa, Israel.
  5. 5Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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Abstract

Introduction

Coronary artery disease (CAD) is a multifactorial condition influenced by both genetic predispositions and environmental exposures.Case description

We present a pair of male monozygotic twins diagnosed with identical critical left anterior descending artery stenosis, suggesting a possible hereditary susceptibility involving this coronary segment. One twin presented with acute coronary syndrome while the other was diagnosed with CAD during screening prompted by his sibling's diagnosis.Conclusion

This report underscores the importance of early screening among genetically related individuals and contributes to the understanding of phenotypic variability in genetically identical patients with CAD.Learning points

There is a strong genetic contribution to the anatomical distribution of CAD even when environmental risk factors differ between twins.Thorough cardiovascular risk assessment and management are warranted for asymptomatic identical twins when their co-twin presents with CAD. Early screening for subclinical disease and the consideration of advanced imaging modalities may be justified in this context.

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Cite

BibTeXRIS
BibTeX
@article{cohen2026identical,
  title = {{Identical Critical Left Anterior Descending Artery Stenosis in Monozygotic Twins.}},
  author = {Aya Cohen and Dan Justo and Israel Barabash and Keren Zisman and Asaf Danon},
  journal = {European journal of case reports in internal medicine},
  year = {2026},
  month = oct,
  doi = {10.12890/2026_007079},
  url = {https://europepmc.org/article/MED/43012031},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Identical Critical Left Anterior Descending Artery Stenosis in Monozygotic Twins.
AU  - Aya Cohen
AU  - Dan Justo
AU  - Israel Barabash
AU  - Keren Zisman
AU  - Asaf Danon
PY  - 2026
DA  - 2026/10/26
JO  - European journal of case reports in internal medicine
DO  - 10.12890/2026_007079
UR  - https://europepmc.org/article/MED/43012031
AB  - Introduction  Coronary artery disease (CAD) is a multifactorial condition influenced by both genetic predispositions and environmental exposures.Case description  We present a pair of male monozygotic twins diagnosed with identical critical left anterior descending artery stenosis, suggesting a possible hereditary susceptibility involving this coronary segment. One twin presented with acute coronary syndrome while the other was diagnosed with CAD during screening prompted by his sibling's diagnosis.Conclusion  This report underscores the importance of early screening among genetically related individuals and contributes to the understanding of phenotypic variability in genetically identical patients with CAD.Learning points  There is a strong genetic contribution to the anatomical distribution of CAD even when environmental risk factors differ between twins.Thorough cardiovascular risk assessment and management are warranted for asymptomatic identical twins when their co-twin presents with CAD. Early screening for subclinical disease and the consideration of advanced imaging modalities may be justified in this context.
SN  - 2284-2594
ER  -