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Peer-reviewedCC BY-NC-NDJournal of Clinical and Diagnostic Research

Human Amnion Grafting for Vaginal Agenesis in Mayer-Rokitansky-Kuster-Hauser Syndrome: A Case Report

  • Hemant Deshpande1
  • Shriraj Katakdhond2
  • Abira Ghosh3
  1. 1Professor and Head, Department of Obstetrics and Gynaecology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.
  2. 2Associate Professor, Department of Obstetrics and Gynaecology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.
  3. 3Research Assistant, Department of Central Research Facility, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.
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Abstract

Vaginal agenesis is a congenital condition of the female genital tract. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a disorder characterised by agenesis of Mullerian structures, including the uterus and upper two-thirds of the vagina, with normally developed secondary sexual characteristics. The author presents a case of a 21-year-old married woman with primary amenorrhoea diagnosed with type 1 MRKH syndrome. The patient underwent the modified McIndoe vaginoplasty procedure with the use of a human amnion as a graft for creating a neovagina. The patient was discharged fifteen days postsurgery with training on the use of vaginal dilators. The patient was followed up weekly to assess vaginal patency. At the end of three months, the patient had approximately 7 cm of neovaginal length.Sexual intercourse was recommended thereafter.Modified McIndoe vaginoplasty with a human amnion graft is an effective, simple, safe procedure with high acceptability and a good enough functional vagina in women with MRKH syndrome.

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Cite

BibTeXRIS
BibTeX
@article{deshpande2026human,
  title = {{Human Amnion Grafting for Vaginal Agenesis in Mayer-Rokitansky-Kuster-Hauser Syndrome: A Case Report}},
  author = {Hemant Deshpande and Shriraj Katakdhond and Abira Ghosh},
  journal = {Journal of Clinical and Diagnostic Research},
  year = {2026},
  month = oct,
  doi = {10.7860/jcdr/2026/92046.24659},
  url = {https://doi.org/10.7860/jcdr/2026/92046.24659},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Human Amnion Grafting for Vaginal Agenesis in Mayer-Rokitansky-Kuster-Hauser Syndrome: A Case Report
AU  - Hemant Deshpande
AU  - Shriraj Katakdhond
AU  - Abira Ghosh
PY  - 2026
DA  - 2026/10/30
JO  - Journal of Clinical and Diagnostic Research
DO  - 10.7860/jcdr/2026/92046.24659
UR  - https://doi.org/10.7860/jcdr/2026/92046.24659
AB  - Vaginal agenesis is a congenital condition of the female genital tract. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a disorder characterised by agenesis of Mullerian structures, including the uterus and upper two-thirds of the vagina, with normally developed secondary sexual characteristics. The author presents a case of a 21-year-old married woman with primary amenorrhoea diagnosed with type 1 MRKH syndrome. The patient underwent the modified McIndoe vaginoplasty procedure with the use of a human amnion as a graft for creating a neovagina. The patient was discharged fifteen days postsurgery with training on the use of vaginal dilators. The patient was followed up weekly to assess vaginal patency. At the end of three months, the patient had approximately 7 cm of neovaginal length.Sexual intercourse was recommended thereafter.Modified McIndoe vaginoplasty with a human amnion graft is an effective, simple, safe procedure with high acceptability and a good enough functional vagina in women with MRKH syndrome.
SN  - 2249-782X
SN  - 0973-709X
ER  -