Glyoxalase 1 (GLO1) Deficiency Is Associated with Myeloid Skewing and Altered Inflammatory Responses.
- 1Department of Internal Medicine, School of Medicine, Kangwon National University, Kangwon National University Hospital, Chuncheon 24341, Korea.
- 2Department of Chronic Disease Convergence Research Division of Intractable Disease Research, National Center for Stem Cell and Regenerative Medicine, Cheongju 28160, Korea.
Abstract
Glyoxalase 1 (GLO1) is involved in cellular adaptation to metabolic and oxidative stress, however, its role in regulating immune homeostasis remains poorly understood. Here, we used Glo1 knockout (Glo1-KO) mice to investigate the effects of GLO1 deficiency on bone marrow (BM) hematopoietic composition and the pulmonary inflammation environment. Flow cytometric analysis revealed alterations in BM myeloid-derived suppressor cell population, in Glo1-KO mice. In the lung GLO1 deficiency was accompanied by increased expression of inflammation and tissue-remodeling-associated genes, indicating an altered pulmonary inflammation milieu. Together, these findings demonstrate that GLO1 deficiency is associated with coordinated changes in hematopoietic immune environments and suggest that GLO1 may influence immune regulation across hematopoietic and peripheral tissue compartments.
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BibTeX
@article{jung2026glyoxalase,
title = {{Glyoxalase 1 (GLO1) Deficiency Is Associated with Myeloid Skewing and Altered Inflammatory Responses.}},
author = {Ji-Hye Jung and Ji-Young Kim and Suji Jeong and Ji Yoon Lee and Seon-Sook Han and Seok-Ho Hong},
journal = {Development \& reproduction},
year = {2026},
month = sep,
doi = {10.12717/dr.2026.30.3.145},
url = {https://europepmc.org/article/MED/42898577},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Glyoxalase 1 (GLO1) Deficiency Is Associated with Myeloid Skewing and Altered Inflammatory Responses.
AU - Ji-Hye Jung
AU - Ji-Young Kim
AU - Suji Jeong
AU - Ji Yoon Lee
AU - Seon-Sook Han
AU - Seok-Ho Hong
PY - 2026
DA - 2026/09/30
JO - Development & reproduction
DO - 10.12717/dr.2026.30.3.145
UR - https://europepmc.org/article/MED/42898577
AB - Glyoxalase 1 (GLO1) is involved in cellular adaptation to metabolic and oxidative stress, however, its role in regulating immune homeostasis remains poorly understood. Here, we used Glo1 knockout (Glo1-KO) mice to investigate the effects of GLO1 deficiency on bone marrow (BM) hematopoietic composition and the pulmonary inflammation environment. Flow cytometric analysis revealed alterations in BM myeloid-derived suppressor cell population, in Glo1-KO mice. In the lung GLO1 deficiency was accompanied by increased expression of inflammation and tissue-remodeling-associated genes, indicating an altered pulmonary inflammation milieu. Together, these findings demonstrate that GLO1 deficiency is associated with coordinated changes in hematopoietic immune environments and suggest that GLO1 may influence immune regulation across hematopoietic and peripheral tissue compartments.
SN - 2465-9525
SN - 2465-9541
ER -