A Rare Case of Slowly Progressive Meningitis Caused by Streptococcus intermedius

Abstract

This report describes a case of Streptococcus intermedius meningitis with an unusually gradual clinical course in an elderly patient with cancer. Such a subacute-to-chronic presentation has not been reported previously. Although S. intermedius meningitis typically involves intracranial suppuration, systemic imaging has revealed no abscesses or other infectious foci. The identification of this pathogen can be challenging in some clinical settings. In this patient, S. intermedius bacteremia was confirmed, whereas cerebrospinal fluid cultures were negative. However, a 16S rRNA gene analysis successfully identified S. intermedius in the cerebrospinal fluid. This case highlights the broad clinical manifestations of this reemerging pathogen and supports the utility of molecular diagnostic methods.

Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia‐Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10
Clément Desjardins, Jiyoon Baik, Lorenzo Bresciani +7
Movement Disorders Clinical Practice26 Aug 2026Peer-reviewedCC BY 4.0Full textGenetics & genomics Human geneticsHAL
Evolutionary branching under slowly evolving constraints
H. C. Ito
bioRxiv21 Sep 2026PreprintAll rights reservedFull textEvolutionary biologybioRxiv
Slow change blindness from serial dependence: slowly changing objects are perceived as biased toward the past.
Haley G Frey, David Whitney
BMC biology3 Aug 2026Peer-reviewedCC BYFull textNeuroscienceEurope PMCPMC
Brainstem cholinergic cell loss causes slowly-developing motor impairments
K. Udobi, V. Aleman, V. Lewitus +9
bioRxiv16 Oct 2026PreprintCC BY-NCFull textNeurosciencebioRxiv
Diagnostic performance of cerebrospinal fluid examination in cases with suspected acute meningitis: a systematic review and meta-analysis
Nina S. Groeneveld, Sabine E. Olie, Nicolò Binello +6
BMC Medicine28 Oct 2026Peer-reviewedCC BY-NC-ND 4.0MicrobiologyCrossref

Cite

BibTeX RIS

BibTeX

@article{kawano2026rare,
  title = {{A Rare Case of Slowly Progressive Meningitis Caused by Streptococcus intermedius}},
  author = {Yuri Kawano and Toshitaka Kamon and Rika Hagihara and Nobuo Ito},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6465-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6465-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - A Rare Case of Slowly Progressive Meningitis Caused by Streptococcus intermedius
AU  - Yuri Kawano
AU  - Toshitaka Kamon
AU  - Rika Hagihara
AU  - Nobuo Ito
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6465-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6465-25/_article
AB  - This report describes a case of Streptococcus intermedius meningitis with an unusually gradual clinical course in an elderly patient with cancer. Such a subacute-to-chronic presentation has not been reported previously. Although S. intermedius meningitis typically involves intracranial suppuration, systemic imaging has revealed no abscesses or other infectious foci. The identification of this pathogen can be challenging in some clinical settings. In this patient, S. intermedius bacteremia was confirmed, whereas cerebrospinal fluid cultures were negative. However, a 16S rRNA gene analysis successfully identified S. intermedius in the cerebrospinal fluid. This case highlights the broad clinical manifestations of this reemerging pathogen and supports the utility of molecular diagnostic methods.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

Related

Cite