Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.
- 1From the Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
- 2Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Abstract
Infectious or biofilm-related inflammatory complications after dermal filler injection are uncommon but may be recurrent and challenging to manage. We report the case of a 44-year-old woman with recurrent erythema, tenderness, and induration in the right tear trough/infraorbital region after facial filler injection performed at an outside facility (reportedly hyaluronic acid, but the filler type was unverified). She had a normal temperature and normal routine laboratory test results. Because ultrasound suggested a small, immature fluid collection and the patient preferred conservative treatment, no incision and drainage was performed. She was treated with repeated intralesional injections of 5-fluorouracil, triamcinolone acetonide, and hyaluronidase. After multiple relapses despite prior systemic antibiotic therapy (details unavailable), repeated intralesional combination therapy achieved sustained clinical resolution. A localized contour depression was noted during follow-up. Intralesional 5-fluorouracil with triamcinolone and hyaluronidase may be a salvage option for refractory postfiller inflammatory complications with suspected infectious/biofilm involvement, particularly when conventional approaches are unsuccessful. Further studies are needed to define indications and optimal dosing.
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BibTeX
@article{qin2026recurrent,
title = {{Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.}},
author = {Mengzhe Qin and Yutong Liang and Jiaqi Yao and Xueshang Su and Jun Zhuang and Ziming Zhang and Jintian Hu},
journal = {Plastic and reconstructive surgery. Global open},
year = {2026},
month = oct,
doi = {10.1097/gox.0000000000008194},
url = {https://europepmc.org/article/MED/42903471},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Recurrent Delayed Inflammatory Reaction After Dermal Filler Injection Treated With Intralesional 5-fluorouracil, Triamcinolone, and Hyaluronidase.
AU - Mengzhe Qin
AU - Yutong Liang
AU - Jiaqi Yao
AU - Xueshang Su
AU - Jun Zhuang
AU - Ziming Zhang
AU - Jintian Hu
PY - 2026
DA - 2026/10/19
JO - Plastic and reconstructive surgery. Global open
DO - 10.1097/gox.0000000000008194
UR - https://europepmc.org/article/MED/42903471
AB - Infectious or biofilm-related inflammatory complications after dermal filler injection are uncommon but may be recurrent and challenging to manage. We report the case of a 44-year-old woman with recurrent erythema, tenderness, and induration in the right tear trough/infraorbital region after facial filler injection performed at an outside facility (reportedly hyaluronic acid, but the filler type was unverified). She had a normal temperature and normal routine laboratory test results. Because ultrasound suggested a small, immature fluid collection and the patient preferred conservative treatment, no incision and drainage was performed. She was treated with repeated intralesional injections of 5-fluorouracil, triamcinolone acetonide, and hyaluronidase. After multiple relapses despite prior systemic antibiotic therapy (details unavailable), repeated intralesional combination therapy achieved sustained clinical resolution. A localized contour depression was noted during follow-up. Intralesional 5-fluorouracil with triamcinolone and hyaluronidase may be a salvage option for refractory postfiller inflammatory complications with suspected infectious/biofilm involvement, particularly when conventional approaches are unsuccessful. Further studies are needed to define indications and optimal dosing.
SN - 2169-7574
ER -